Helicobacter pylori and gastric cancer: mechanisms and new perspectives

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 23, 2025

Gastric cancer remains a significant global health challenge, with Helicobacter pylori (H. pylori) recognized as major etiological agent, affecting an estimated 50% of the world's population. There has been rapidly expanding knowledge molecular and pathogenetic mechanisms H. over decades. This review summarizes latest research advances to elucidate underlying infection in gastric carcinogenesis. Our investigation reveals complex network involving STAT3, NF-κB, Hippo, Wnt/β-catenin pathways, which are dysregulated caused by pylori. Furthermore, we highlight role inducing oxidative stress, DNA damage, chronic inflammation, cell apoptosis—key cellular events that pave way for Emerging evidence also suggests effect on tumor microenvironment its possible implications immunotherapy. synthesizes current identifies gaps warrant further investigation. Despite progress our previous development pylori-induced cancer, comprehensive pylori's is crucial advancement prevention treatment strategies. By elucidating these mechanisms, aim provide more in-depth insights study pylori-related cancer.

Language: Английский

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The complex interplay of tumor-infiltrating cells in driving therapeutic resistance pathways

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 19, 2024

Drug resistance remains a significant challenge in cancer treatment. Recently, the interactions among various cell types within tumor microenvironment (TME) have deepened our understanding of mechanisms behind treatment resistance. Therefore, this review aims to synthesize current research focusing on infiltrating cells and drug suggesting that targeting TME could be viable strategy combat issue. Numerous factors, including inflammation, metabolism, senescence, hypoxia, angiogenesis, contribute Overexpression STAT3 is commonly associated with drug-resistant or stromal cells. Current often generalizes impact resistance, lacking specificity statistical robustness. Thus, future should take notice issue aim provide high-quality evidence. Despite existing limitations, overcome therapy hold promising valuable potential.

Language: Английский

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Inhibition of urate induced pyroptosis and reabsorption transporters overexpression in human renal tubular epithelial cells by low molecular weight fucoidan, as well as its anticoagulation and antioxidation

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 293, P. 139454 - 139454

Published: Jan. 2, 2025

Language: Английский

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A comprehensive review of preparation and pharmacology of low molecular weight fucoidan

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143976 - 143976

Published: May 8, 2025

Language: Английский

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