Current innovations in mRNA vaccines for targeting multidrug-resistant ESKAPE pathogens DOI Creative Commons
Saber İmani,

S. Lv,

Hongbo Qian

et al.

Biotechnology Advances, Journal Year: 2024, Volume and Issue: unknown, P. 108492 - 108492

Published: Dec. 1, 2024

The prevalence of multidrug-resistant (MDR) ESKAPE pathogens, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, represents a critical global public health challenge. In response, mRNA vaccines offer an adaptable scalable platform for immunotherapy against pathogens by encoding specific antigens that stimulate B-cell-driven antibody production CD8

Language: Английский

mRNA vaccine platforms: linking infectious disease prevention and cancer immunotherapy DOI Creative Commons
Dariush Haghmorad, Majid Eslami,

Niloufar Orooji

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 12, 2025

The advent of mRNA vaccines, accelerated by the global response to COVID-19 pandemic, marks a transformative shift in vaccine technology. In this article, we discuss development, current applications, and prospects vaccines for both prevention treatment infectious diseases oncology. By leveraging capacity encode antigens within host cells directly, provide versatile scalable platform suitable addressing broad spectrum pathogens tumor-specific antigens. We highlight recent advancements design, innovative delivery mechanisms, ongoing clinical trials, with particular emphasis on their efficacy combating diseases, such as COVID-19, Zika, influenza, well emerging potential cancer immunotherapy. also address critical challenges, including stability, optimization immune responses, broader issue accessibility. Finally, review strategies advancing next-generation aim overcoming limitations technology enhancing preventive therapeutic approaches oncological diseases.

Language: Английский

Citations

1
RNA therapeutics in cardiovascular medicine DOI
Tulsi Ram Damase, John P. Cooke

Current Opinion in Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Purpose of review RNA therapeutics came to global attention when mRNA-based vaccines provided an answer the SARS-CoV-2 pandemic. The immense significance this development notwithstanding, it is important note that almost a decade prior pandemic, drugs had made inroads toward amelioration disease. first class therapies be introduced into clinical use were antisense oligomers and siRNA which generally induce therapeutic effect by acting brake or modulate mRNA expression. quickly becoming fourth pillar pharmacotherapy, will have broad applications, including for treatment cardiovascular Recent findings United States (US) Food Drug Administration (FDA) has approved several (ASOs) siRNA-based treat disorders associated with In addition, multiple RNA-based are in trials assess their safety efficacy patients disorders, such as Zodasiran, therapy targets angiopoietin-like protein 3 (ANGPTL3) reduce LDL cholesterol. Summary Because limitless sequence choice; speed design; relative ease synthesis, rapidly developed, generated at lower cost than other drug types. This aims highlight diseases approved, those under evaluation.

Language: Английский

Citations

0
Engineering Useful Microbial Species for Pharmaceutical Applications DOI Creative Commons
А.К. САДАНОВ, B.B. BAIMAKHANOVA,

Saltanat Emilievna Orasymbet

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 599 - 599

Published: March 5, 2025

Microbial engineering has made a significant breakthrough in pharmaceutical biotechnology, greatly expanding the production of biologically active compounds, therapeutic proteins, and novel drug candidates. Recent advancements genetic engineering, synthetic biology, adaptive evolution have contributed to optimization microbial strains for applications, playing crucial role enhancing their productivity stability. The CRISPR-Cas system is widely utilized as precise genome modification tool, enabling enhancement metabolite biosynthesis activation biological pathways. Additionally, biology approaches allow targeted design microorganisms with improved metabolic efficiency potential, thereby accelerating development new products. integration artificial intelligence (AI) machine learning (ML) plays vital further advancing by predicting network interactions, optimizing bioprocesses, discovery process. However, challenges such efficient pathways, ensuring sustainable industrial-scale production, meeting international regulatory requirements remain critical barriers field. Furthermore, mitigate potential risks, it essential develop stringent biocontainment strategies implement appropriate oversight. This review comprehensively examines recent innovations analyzing key technological advancements, challenges, future perspectives.

Language: Английский

Citations

0
Current advancement of immune function paradox of tumour-infiltrating cells and their immunotherapeutic targets: a mini-review DOI

VEENA V. TOM,

A. De la Fuente Hernández José, Sumit Mallick

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Lipid Nanoparticles for mRNA Delivery in Cancer Immunotherapy DOI
Yasir Alshehry, Xiang Liu,

Wenhua Li

et al.

The AAPS Journal, Journal Year: 2025, Volume and Issue: 27(3)

Published: March 18, 2025

Language: Английский

Citations

0
Bibliometric and visual analysis of drug-specific immunotherapy from 1990 to 2024 DOI Creative Commons
Zhengjiu Cui, Xiaorui Chen,

Shuaishuai Zhai

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Specific immunotherapy (SIT) is key in allergic diseases, tumor immunity, and autoimmune regulation. In recent years, the mechanism of action drugs SIT has attracted much attention, including induction hypersensitivity responses modulation immune tolerance. However, scientific challenges remain regarding their optimization strategies. Studies on pharmacological have been accumulated past, there an urgent need for bibliometric analyses to review prospect these results future academic development. Strict search criteria were developed screen download literature information from Web Science Core Collection. Six elements included analyzed visualized using Citespace, VOSviewer software, Bibliometrix package. A total 682 publications related drug this study. The growth trend number evident entering a new phase with great potential future, highest citations 1998. countries institutions most USA University Genoa. author who contributed field was Incorvaia, Cristoforo. Moreover, Bousquet J influential author. Allergy considered leading core source journal, Journal Clinical Immunology influential. reference outbreak intensity Roberts G, 2018, Allergy, V73, P765, https://doi.org/10.1111/all.13317 . analysis keywords by various metrics shows that research hotspot tumor-associated SIT, cutting-edge topic AIT, respiratory application hot issue. Drug made good progress joint participation global institutions, scientists, journals. cooperation communication are weak, it necessary build mode promote globalization results. We found hotspots issues field, which will guide us make breakthroughs more precise direction play important role safety safeguarding human life health.

Language: Английский

Citations

0
Current innovations in mRNA vaccines for targeting multidrug-resistant ESKAPE pathogens DOI Creative Commons
Saber İmani,

S. Lv,

Hongbo Qian

et al.

Biotechnology Advances, Journal Year: 2024, Volume and Issue: unknown, P. 108492 - 108492

Published: Dec. 1, 2024

The prevalence of multidrug-resistant (MDR) ESKAPE pathogens, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, represents a critical global public health challenge. In response, mRNA vaccines offer an adaptable scalable platform for immunotherapy against pathogens by encoding specific antigens that stimulate B-cell-driven antibody production CD8

Language: Английский

Citations

0