Therapeutic potential of natural arginase modulators: mechanisms, challenges, and future directions DOI Creative Commons
Ting Li,

Jieying Wang,

Huan Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Arginase (Arg) plays a pivotal role in numerous pathological processes, with its dysregulated expression being intricately associated tumor progression and immune evasion. This review comprehensively examines the diversity, mechanisms, clinical potential of natural Arg modulators, encompassing polyphenols, flavonoids, terpenoids. These bioactive compounds exert their modulatory effects on activity through multiple including direct enzyme interaction, regulation signaling pathways, modulation cellular metabolism. The therapeutic these metabolites spans across various medical domains, notably cardiovascular diseases, oncology, neurological disorders, inflammatory conditions. Specifically, polyphenol such as resveratrol curcumin have demonstrated significant benefits health neuroprotection, while flavonoids rutin quercetin shown promising intracellular factors cell proliferation. Similarly, terpenoids like perillyl alcohol triptolide been found to influence polarization processes. However, despite substantial experimental studies, development modulators faces several challenges. include complexities drug design attributed intricate structure isoforms Arg, difficulties elucidating precise mechanisms due Arg’s multifaceted roles metabolic limitations current delivery systems. To overcome challenges, future research should focus continuous optimization paradigms, enhancement models data quality, thorough evaluation efficacy, strategic integration precision medicine approaches.

Language: Английский

Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway DOI Creative Commons

Shiming Tan,

Shizhen Li,

Longzheng Xia

et al.

International Journal of Oncology, Journal Year: 2025, Volume and Issue: 66(3)

Published: Feb. 11, 2025

Long non‑coding (lnc)RNAs participate in colorectal cancer (CRC) occurrence and progression. The present study aimed to investigate whether lncRNA ABHD11‑AS1 regulates malignant biological behavior of CRC cells. Bioinformatic analysis, reverse transcription‑quantitative PCR situ hybridization revealed that expression was decreased samples associated with an unfavorable prognosis. overexpression significantly proliferation, migration invasion cells, whereas inhibition had the opposite effects. interacted EGFR inhibit phosphorylation attenuate EGFR/ERK signaling, which turn suppressed tumor suppressor function attenuated by agonist NSC228155. Finally, resveratrol (RSV) inhibited cell invasion, may be RSV‑induced decrease SPT6 homolog, histone chaperone transcription elongation factor protein increase transcript levels. signaling interacting EGFR, thereby delaying progression CRC. ABHD11‑AS1/EGFR/ERK axis a novel therapeutic target for preventing

Language: Английский

Citations

0
Model systems for comprehensive assessment of the nutraceuticals expected efficiency in relation to metabolic syndrome DOI

Aleksandra Utkina,

Tatiana Kovianova,

Daria Panteleeva

et al.

Food Industry, Journal Year: 2025, Volume and Issue: 10(1), P. 62 - 72

Published: March 26, 2025

Using chemical and cellular models, popular nutraceuticals (amaranth, glucan, resveratrol) the drug Dibicor (taurine) were tested for their effectiveness against metabolic syndrome processes. For each object, antioxidant activity (AOA) values degree of influence on target genes associated with inflammation determined. transcriptome analysis method, 12 proinflammatory 9 anti-inflammatory differentially expressed by certain or taurine identified. The multitarget action nutraceuticals, contributing to syndrome, was confirmed, while a cause-and-effect relationship between oxidation not established. assessment based AOA alone is insufficient should be clarified testing more complex model, which true at least pathology under consideration.

Language: Английский

Citations

0
Therapeutic potential of natural arginase modulators: mechanisms, challenges, and future directions DOI Creative Commons
Ting Li,

Jieying Wang,

Huan Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Arginase (Arg) plays a pivotal role in numerous pathological processes, with its dysregulated expression being intricately associated tumor progression and immune evasion. This review comprehensively examines the diversity, mechanisms, clinical potential of natural Arg modulators, encompassing polyphenols, flavonoids, terpenoids. These bioactive compounds exert their modulatory effects on activity through multiple including direct enzyme interaction, regulation signaling pathways, modulation cellular metabolism. The therapeutic these metabolites spans across various medical domains, notably cardiovascular diseases, oncology, neurological disorders, inflammatory conditions. Specifically, polyphenol such as resveratrol curcumin have demonstrated significant benefits health neuroprotection, while flavonoids rutin quercetin shown promising intracellular factors cell proliferation. Similarly, terpenoids like perillyl alcohol triptolide been found to influence polarization processes. However, despite substantial experimental studies, development modulators faces several challenges. include complexities drug design attributed intricate structure isoforms Arg, difficulties elucidating precise mechanisms due Arg’s multifaceted roles metabolic limitations current delivery systems. To overcome challenges, future research should focus continuous optimization paradigms, enhancement models data quality, thorough evaluation efficacy, strategic integration precision medicine approaches.

Language: Английский

Citations

0