Al- Anbar Medical Journal, Journal Year: 2023, Volume and Issue: 0(0), P. 0 - 0
Published: Oct. 11, 2023
Language: Английский
Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2480 - 2480
Published: Sept. 7, 2023
The gut microbiota (GM) plays a vital role in human health, with increasing evidence linking its imbalance to chronic kidney disease and end-stage disease. Although the exact methods underlying kidney-GM crosstalk are not fully understood, interventions targeting GM were made lay three aspects: diagnostic, predictive, therapeutic interventions. While these show promising results reducing uremic toxins inflammation, challenges remain form of patient-specific variability, potential side effects, safety concerns. Our understanding GMs is still evolving, necessitating further research elucidate causal relationship mechanistic interactions. Personalized focusing on specific signatures could enhance patient outcomes. However, comprehensive clinical trials needed validate approaches’ safety, efficacy, feasibility.
Language: Английский
Citations
21
Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), Journal Year: 2025, Volume and Issue: 8(1), P. 48 - 55
Published: Feb. 9, 2025
Background: Sepsis post retrograde renal surgery (RIRS) is a grave complication. Proper monitoring, antibiotic management, and understanding of risk factors are crucial to reduce sepsis enhance patient outcomes. Objective: To determine causing postoperative after RIRS for stones. Methods: A retrospective/prospective cohort enrolled 145 patients who underwent and/or ureteral stones at Ghazi AL-Hariri Hospital Surgical Specialties. Eligible data were collected, including demographic (age, gender), stone parameters (site, side, size), preoperative investigations regimen, operative (type ureteroscope used, prior DJ stent), records. Results: Patients aged 19-69 years, predominantly males (60.7%), 25.5% had diabetes. Stones located in the upper pole (36.6%), 44.8% medium-sized (15-20 mm), 49.7% moderate density (800–1200 HU). Post-operatively, 17% cases developed urosepsis. Multivariate analysis identified diabetes, longer duration, elevated CRP, uncontrolled HbA1c as independent E. coli was most common pathogen (44%). The average hospital stay 2 days, with discharged within single day. median duration stenting 6 weeks. Conclusions: Analysis highlights multifactorial developing urosepsis post-RIRS, procedural time, higher inflammatory markers, complex characteristics. Comprehensive planning meticulous intraoperative techniques will alleviate these risks help urologists maximize outcomes minimize incidence.
Language: Английский
Citations
0
Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), Journal Year: 2025, Volume and Issue: 8(1), P. 148 - 153
Published: March 1, 2025
Background: Acute infectious gastroenteritis (AG) stands for one of the commonest causes death in children under 5 years age. Objective: To assess prevalence viral etiology hospitalized watery diarrhea and identify relation between patients’ characteristics underlying AG. Methods: A cross-sectional study included with AG who presented diarrhea. Three sets data were collected: sociodemographic (age, gender, residence, type feeding, method sterilization, number family members, socioeconomic status), clinical (duration illness, frequency per day, presence vomiting, degree dehydration, fever, napkin rash), laboratory result (white blood cell count, C-reactive protein, pus on general stool exam, detected by immunoassay). Results: total 216 aged less than included, 170(78.7%) 1 year Less two-thirds patients (59%) had identified etiology, which 102 (47%) rotavirus their 26(12%) adenoviruses detected. Four factors significantly related to etiology: age year, male sex adenovirus female rotavirus, formula status. Conclusions: The highlights an increasing detection diarrhea, remaining most pathogen, followed adenovirus.
Language: Английский
Citations
0
Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 1493 - 1510
Published: March 1, 2025
Abstract: This review explores the multifaceted roles and applications of probiotics, emphasizing their significance in maintaining enhancing host health through microbial interactions. It includes concept holobionts symbiotic relationships between hosts microbiomes, illustrating how various microbiota can enhance immunity, support growth, prevent diseases. delves into customization probiotics using molecular genomic techniques, focusing Enterococcus, Bifidobacterium , Lactobacillus species. Furthermore, it discusses effects symbiotics which aids survivability beneficial probiotics. The role microbes gut is emphasized, noting its impact on preventing diseases a stable community. potential therapeutic value ability to treat gastrointestinal diseases, as well strengthen immune system reduce number free radicals that are present body. Additionally, secondary metabolites produced by bacteria gut, such bacteriocins exopolysaccharides, effect human, particularly tract. concludes addressing use traditional medicine novel applications, including treatment endangered wildlife species human ailments. Keywords: health, microbiota, metabolites, synergistic
Language: Английский
Citations
0
The Open Medicinal Chemistry Journal, Journal Year: 2025, Volume and Issue: 19(1)
Published: April 16, 2025
Fibrocystic breast change (FBC) is a prevalent benign condition that affects women of reproductive age. Hormonal fluctuation during the menstrual cycle suggested pathology. Affected suffer cyclical pain (mastalgia), texture, and nipple discharge. Multiple diagnostic therapeutic approaches were used to address mastalgia in FCB; last decade witnessed considerable advancement modalities, showing variable degrees efficacy alleviating mastalgia. This review aims examine recent data linked FCB diagnosis, addition discussing comparing latest options cases. An online search was conducted via four major electronic databases using keywords related FCB, pathology, imaging, therapy. Data interest extracted analyzed. Our findings indicate mammography takes lead ultrasound complementary. Innovative bioinformatics holds promise improving precision outcomes. Lifestyle changes remain first option, which combined with drug therapy tailored according etiology nature varying degree efficacy. strategies discussed, good efficacy, low rate side effects, high patient acceptability. Empowering physicians knowledge will refine challenges, guide choices, enhance outcomes, allow holistically centered health care. Future research needed explore optimal follow-up approaches, added best treatment combinations newer therapies better safety profiles more satisfaction.
Language: Английский
Citations
0
Current Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 31(30), P. 4807 - 4825
Published: May 2, 2024
: To date, the underlying pathology of inflammatory bowel disease (IBD) is undetermined. Disturbance intestinal gut microbiota was implicated in many health diseases, including IBD. Increasing evidence suggests that probiotics play a beneficial role restoring balance ecosystem. This review searched multiple databases for relevant works examined probiotics' possible benefits adults with Probiotic mode action ulcerative colitis patients and Crohn's were respect to probiotic strain, their benefits, advantages adult cases. Eligible studies inclusion assessed analyzed. They effective reducing IBD course, inducing maintaining remission, particularly patients, good efficacy safety profile. However, lacking. Probiotics positively affect IBD-related risks, risk gastrointestinal malignancy optimizing treating them. Additionally, they improved reduced fertility odds both genders. The osteoporosis among also reduced, although duration use dose still not established. There an encouraging them -cardiovascular risks cases acute myocardial infarction those chronic heart failure. Finally, had novel depression overall mental health. In conclusion, we recommend as adjuvant therapeutic option therapy colitis; however, needs further research.
Language: Английский
Citations
0
Journal of Medicine and Life, Journal Year: 2024, Volume and Issue: 17(10), P. 948 - 952
Published: Oct. 1, 2024
The connection between the immune response and composition of gut microbiota has been associated with an increased prevalence atopic dermatitis in first year life. study aimed to investigate characteristics infants compared healthy better understand link early-life development dermatitis. analyzed intestinal 121 clinical signs dermatitis, divided into Group I (infants dermatitis) II (healthy controls). showed that presented values proteolytic bacteria mainly represented by Enterobacter species (P = 0.041), Klebsiella 0.038), Escherichia coli 0.013), significantly decreased levels acidifying Enterococcus species, Lactobacillus Bifidobacterium < 0.05) normal Clostridium Candida albicans, Mould fungi Geotrichum species. This highlights distinct differences providing insights dynamic ecosystem during early life for future personalized therapeutic strategies.
Language: Английский
Citations
0
Al- Anbar Medical Journal, Journal Year: 2023, Volume and Issue: 0(0), P. 0 - 0
Published: Oct. 11, 2023
Language: Английский
Citations
0