Analysis of Lung Cancer Incidence in Non-Hispanic Black and White Americans using a Multistage Carcinogenesis Model DOI Creative Commons
Sarah Skolnick, Pianpian Cao, Jihyoun Jeon

et al.

Cancer Causes & Control, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract Purpose There are complex and paradoxical patterns in lung cancer incidence by race/ethnicity gender; compared to non-Hispanic White (NHW) males, Black (NHB) males smoke fewer cigarettes per day less frequently but have higher rates. Similarly, NHB females likely comparable rates NHW females. We use a multistage carcinogenesis model study the impact of smoking on individuals Multiethnic Cohort Study (MEC). Methods The effects tumor initiation, promotion, malignant conversion, versus adults MEC were analyzed using Two-Stage Clonal Expansion (TSCE) model. Maximum likelihood methods used estimate parameters assess differences race/ethnicity, gender, history. Results Smoking increased promotion conversion did not affect initiation. Non-smoking-related smoking-related differed gender. initiation than individuals, whereas was lower individuals. Conclusion Findings suggest that while plays an important role risk, background risk dependent also significant under-recognized explaining differences. Ultimately, resulting TSCE will inform race/ethnicity-specific natural history models preventive interventions US outcomes disparities race/ethnicity.

Language: Английский

Early Detection and Interception of Lung Cancer DOI
Allison E.B. Chang, Alexandra L. Potter, Chi‐Fu Jeffrey Yang

et al.

Hematology/Oncology Clinics of North America, Journal Year: 2024, Volume and Issue: 38(4), P. 755 - 770

Published: May 8, 2024

Language: Английский

Citations

0
Ferroptosis related CPT1A and GDF15 gene polymorphisms are risk factors for lung adenocarcinoma: A case-control study DOI
Xing Zhang, Rong Wang, Xia Zhang

et al.

Gene, Journal Year: 2024, Volume and Issue: 933, P. 149002 - 149002

Published: Oct. 12, 2024

Language: Английский

Citations

0
Analysis of Lung Cancer Incidence in Non-Hispanic Black and White Americans using a Multistage Carcinogenesis Model DOI Creative Commons
Sarah Skolnick, Pianpian Cao, Jihyoun Jeon

et al.

Cancer Causes & Control, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract Purpose There are complex and paradoxical patterns in lung cancer incidence by race/ethnicity gender; compared to non-Hispanic White (NHW) males, Black (NHB) males smoke fewer cigarettes per day less frequently but have higher rates. Similarly, NHB females likely comparable rates NHW females. We use a multistage carcinogenesis model study the impact of smoking on individuals Multiethnic Cohort Study (MEC). Methods The effects tumor initiation, promotion, malignant conversion, versus adults MEC were analyzed using Two-Stage Clonal Expansion (TSCE) model. Maximum likelihood methods used estimate parameters assess differences race/ethnicity, gender, history. Results Smoking increased promotion conversion did not affect initiation. Non-smoking-related smoking-related differed gender. initiation than individuals, whereas was lower individuals. Conclusion Findings suggest that while plays an important role risk, background risk dependent also significant under-recognized explaining differences. Ultimately, resulting TSCE will inform race/ethnicity-specific natural history models preventive interventions US outcomes disparities race/ethnicity.

Language: Английский

Citations

0