Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

ACS Nano, Journal Year: 2021, Volume and Issue: 15(11), P. 16982 - 17015

Published: June 28, 2021

Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in spotlight vital components COVID-19 mRNA vaccines, LNPs play key role effectively protecting and transporting cells. Liposomes, an early version LNPs, are versatile nanomedicine delivery platform. A number liposomal drugs been approved applied medical practice. Subsequent generations lipid nanocarriers, such solid nanoparticles, nanostructured carriers, cationic lipid–nucleic acid complexes, exhibit more complex architectures enhanced physical stabilities. With their ability encapsulate therapeutics specific locations within body release contents at desired time, provide valuable platform for treatment diseases. Here, we present landscape LNP-related scientific publications, including patents journal articles, based on analysis CAS Content Collection, largest human-curated collection published knowledge. Rising trends identified, carriers becoming preferred platforms numerous formulations. Recent advancements LNP formulations drug platforms, antitumor nucleic vaccine systems, discussed. Challenges growth opportunities also evaluated other areas, imaging, cosmetics, nutrition, agrochemicals. This report is intended serve useful resource those interested nanotechnologies, applications, global research effort development.

Language: Английский

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New approaches and procedures for cancer treatment: Current perspectives

SAGE Open Medicine, Journal Year: 2021, Volume and Issue: 9

Published: Jan. 1, 2021

Cancer is a global health problem responsible for one in six deaths worldwide. Treating cancer has been highly complex process. Conventional treatment approaches, such as surgery, chemotherapy, and radiotherapy, have use, while significant advances are being made recent times, including stem cell therapy, targeted ablation nanoparticles, natural antioxidants, radionics, chemodynamic sonodynamic ferroptosis-based therapy. Current methods oncology focus on the development of safe efficient nanomedicines. Stem therapy brought promising efficacy regenerating repairing diseased or damaged tissues by targeting both primary metastatic foci, nanoparticles new diagnostic therapeutic options. Targeted possessed breakthrough potential inhibiting growth spread specific cells, causing less damage to healthy cells. Ablation emerged minimally invasive procedure that burns freezes cancers without need open surgery. Natural antioxidants demonstrated tracking down free radicals neutralizing their harmful effects thereby treating preventing cancer. Several technologies currently under research clinical trials, some them already approved. This review presented an update breakthroughs therapies.

Language: Английский

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Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: June 23, 2022

Cancer is one of the leading causes death worldwide. Several treatments are available for cancer treatment, but many treatment methods ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions This review describes known MDR mechanisms in cells and discusses ongoing laboratory approaches novel strategies that aim inhibit, circumvent, or reverse development various types. In this review, we discuss both intrinsic acquired drug resistance, addition highlighting hypoxia- autophagy-mediated mechanisms. factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced efflux, cell inhibition, other molecular cellular mechanisms, responsible anticancer agents. Drug can also depend on autophagic hypoxic status. The expression drug-resistant genes regulatory determine discussed. Methods circumvent MDR, immunoprevention, use microparticles nanomedicine might result better fighting

Language: Английский

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Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: July 6, 2023

Abstract Breast cancer is the second leading cause of death for women worldwide. The heterogeneity this disease presents a big challenge in its therapeutic management. However, recent advances molecular biology and immunology enable to develop highly targeted therapies many forms breast cancer. primary objective therapy inhibit specific target/molecule that supports tumor progression. Ak strain transforming, cyclin-dependent kinases, poly (ADP-ribose) polymerase, different growth factors have emerged as potential targets subtypes. Many drugs are currently undergoing clinical trials, some already received FDA approval monotherapy or combination with other treatment yet achieve promise against triple-negative (TNBC). In aspect, immune has come up promising approach specifically TNBC patients. Different immunotherapeutic modalities including immune-checkpoint blockade, vaccination, adoptive cell transfer been extensively studied setting cancer, especially approved blockers chemotherapeutic treat several trials ongoing. This review provides an overview developments advancements immunotherapies treatment. successes, challenges, prospects were critically discussed portray their profound prospects.

Language: Английский

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Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy

Nano Today, Journal Year: 2021, Volume and Issue: 38, P. 101119 - 101119

Published: March 12, 2021

Language: Английский

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Biomedical Applications of Iron Oxide Nanoparticles: Current Insights Progress and Perspectives

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(1), P. 204 - 204

Published: Jan. 16, 2022

The enormous development of nanomaterials technology and the immediate response many areas science, research, practice to their possible application has led publication thousands scientific papers, books, reports. This vast amount information requires careful classification order, especially for specifically targeted practical needs. Therefore, present review aims summarize some extent role iron oxide nanoparticles in biomedical research. Summarizing fundamental properties magnetic nanoparticles, review’s next focus was classify research studies related applying these particles cancer diagnostics therapy (similar photothermal therapy, hyperthermia), nano theranostics, multimodal therapy. Special attention is paid dealing with opportunities combining different achieve optimal systems application. In this regard, original data about synthesis characterization nanolipidic hybrid are included as an example. last section dedicated capacities magnetite-based management oncological diseases.

Language: Английский

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Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges

Biomolecules, Journal Year: 2022, Volume and Issue: 12(6), P. 784 - 784

Published: June 4, 2022

Cancer is one of the main causes death worldwide. To date, and despite advances in conventional treatment options, therapy cancer still far from optimal due to non-specific systemic biodistribution antitumor agents. The inadequate drug concentrations at tumor site led an increased incidence multiple resistance appearance many severe undesirable side effects. Nanotechnology, through development nanoscale-based pharmaceuticals, has emerged provide new innovative drugs overcome these limitations. In this review, we overview approved nanomedicine for rationale behind their designs applications. We also highlight approaches that are currently under investigation perspectives challenges nanopharmaceuticals, focusing on microenvironment disseminate cells as most attractive effective strategies treatments.

Language: Английский

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Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities

ACS Omega, Journal Year: 2023, Volume and Issue: 8(16), P. 14290 - 14320

Published: April 10, 2023

Cancer is ranked as the second leading cause of death globally. Traditional cancer therapies including chemotherapy are flawed, with off-target and on-target toxicities on normal cells, requiring newer strategies to improve cell selective targeting. The application nanomaterial has been extensively studied explored chemical biology tools in theranostics. It shows greater applications toward stability, biocompatibility, increased permeability, resulting precise targeting, mitigating shortcomings traditional therapies. nanoplatform offers an exciting opportunity gain targeting multifunctionality. advent nanotechnology, particular development smart nanomaterials, transformed diagnosis treatment. large surface area nanoparticles enough encapsulate many molecules ability functionalize various biosubstrates such DNA, RNA, aptamers, antibodies, which helps theranostic action. Comparatively, biologically derived nanomaterials perceive advantages over produced by conventional methods terms economy, ease production, reduced toxicity. present review summarizes techniques theranostics emphasizes (such organic (NPs), inorganic NPs, carbon-based NPs). We also critically discussed challenges impeding their translation treatment diagnostic applications. This concludes that use could significantly will facilitate new dimensions for tumor detection therapy.

Language: Английский

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Cancer treatment therapies: traditional to modern approaches to combat cancers

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(11), P. 9663 - 9676

Published: Oct. 12, 2023

Language: Английский

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Remotely controlled near-infrared-triggered photothermal treatment of brain tumours in freely behaving mice using gold nanostars

Nature Nanotechnology, Journal Year: 2022, Volume and Issue: 17(9), P. 1015 - 1022

Published: Aug. 22, 2022

Language: Английский

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