Preventive and Therapeutic Effects of Baicalein, Galangin, and Isorhamnetin in Chronic Liver Diseases: A Narrative Review

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1253 - 1253

Published: March 11, 2025

Chronic liver diseases (CLDs), including fatty disease, fibrosis, and cirrhosis, pose significant global health challenges due to the limitedness of therapeutic options. Flavonoids, a class polyphenolic compounds mainly contained in natural sources foods Mediterranean diet, have emerged as potential candidates for protection their anti-inflammatory, antioxidant, anti-fibrotic properties. Baicalein, derived from Scutellaria baicalensis, exhibits hepatoprotective effects by attenuating oxidative stress, inhibiting fibrogenesis, modulating lipid metabolism. Galangin, flavonoid Alpinia officinarum, has demonstrated anti-inflammatory properties, while isorhamnetin, methylated found various fruits herbs, been shown possess qualities, it reduces stress mitigates inflammation CLDs. This narrative review highlights preventive these three flavonoids, emphasizing role promising agents managing CLDs guiding future research.

Language: Английский

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Improving the Urease Inhibitory Activity of Baicalein Through Conjugation with Bi2O3 Nanoparticles

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 20, 2025

Language: Английский

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Flavonoids serve as a promising therapeutic agent for ischemic stroke

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149528 - 149528

Published: Feb. 1, 2025

Language: Английский

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Anti-inflammatory and antioxidant effects of baicalein: targeting Nrf2, and NFĸB in neurodegenerative disease

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

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In Vivo and Bioinformatics Evaluation of Nine Traditional Chinese Medicine Compounds Targeting Acetylcholinesterase and Butyrylcholinesterase Enzymes in Alzheimer’s Disease

Deleted Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 4, 2025

Background: Alzheimer’s disease (AD) is characterized by cholinergic dysfunction and oxidative stress, creating a need for the development of new therapeutic agents. Traditional Chinese medicine (TCM) compounds, such as hainanolidol norwogonin, have shown potential neuroprotective activity. Objectives: This study investigates inhibitory action these compounds on cholinesterase enzymes their possible application in an AD-like rat model generated lead acetate (PbAc), well-known neurotoxicant that mimics AD-associated damage cognitive decline. Methods: The activity nine TCM was assessed vitro against acetylcholinesterase (AChE) butyrylcholinesterase (BuChE), with donepezil tacrine controls. Hainanolidol identified most potent inhibitors, were further evaluated PbAc-induced AD to assess effects. Oxidative stress biomarkers malondialdehyde (MDA), glutathione (GSH), activity, silico molecular interactions analyzed, including docking studies, dynamics (MD) simulations, ADME-toxicity profiling. Results: norwogonin showed strong nanomolar-range inhibition both AChE BuChE, considerable IC50 values superior those standard inhibitors. In model, significantly reduced MDA levels increased GSH levels, indicating mitigation. level effective as, or more than, suppression achieved treatments, particularly regarding AChE, thus suggesting enhanced compared donepezil. Molecular MD simulations confirmed stable binding key catalytic residues reinforcing mechanisms. analysis demonstrated favorable pharmacokinetics safety profiles. Conclusions: concludes are worthy being regarded dual inhibitors antioxidant properties, which may serve alternative therapeutics AD. use PbAc underscores role environmental neurotoxins pathogenesis, offering insights into novel intervention strategies. Advanced preclinical clinical studies needed validation.

Language: Английский

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The effects of baicalin in depression: preclinical evidence construction based on meta-analysis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 24, 2024

Depression manifests as a mental disorder characterized by low mood, suicidal tendencies, disturbances in sleep-wake cycles, psychomotor agitation, and pronounced feelings of hopelessness anhedonia. Baicalin, natural flavonoid compound, shows significant promise alleviating depressive symptoms animals. This study aims to assess the impact baicalin on experimental models depression.

Language: Английский

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Targeting urotensin II with silymarin: potential therapeutic strategies for diabetes and associated cardiovascular complications

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Language: Английский

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