Benchmarking large language models’ performances for myopia care: a comparative analysis of ChatGPT-3.5, ChatGPT-4.0, and Google Bard

EBioMedicine, Journal Year: 2023, Volume and Issue: 95, P. 104770 - 104770

Published: Aug. 23, 2023

Language: Английский

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Ciliary muscles contraction leads to axial length extension——The possible initiating factor for myopia

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0301844 - e0301844

Published: April 16, 2024

Purpose This study aimed to investigate the underlying factors driving onset of myopia, specifically role ciliary muscle’s contraction in elongation axial length eye. Methods The retrospective was conducted utilizing data from three ophthalmic centers Shanghai and Beijing. Both Chinese Caucasian children were involved. subjects’ eyes measured both relaxed contracted state muscle. A comprehensive mechanical model also developed observe influence muscle on length. Results included a sample 198 right myopic children. Of these, 97 male 101 female, 126 ethnicity 72 Caucasian. age for myopia ranged 5.9 16.9 years old. eye decreased 0.028 ± 0.007mm following dilation, indicating relaxation (t paired student = 15.16, p 6.72 x 10 −35 ). In contrast, resulted an increase Considering proportionality, significant 90.4% (179 eyes) exhibited reduced length, while minor 9.6% (19 demonstrated post-mydriasis. Finite element modeling that caused tension force transmits towards posterior pole eye, causing it extend posteriorly. Conclusion leads extension could potentially be initiating factor myopia.

Language: Английский

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Designing a contact lens with atropine base using a microemulsion technique

Contact Lens and Anterior Eye, Journal Year: 2025, Volume and Issue: unknown, P. 102381 - 102381

Published: Feb. 1, 2025

Myopia or near-sightedness is a global vision problem. Atropine eye drops and myopia-controlling contact lenses can help to slow down its progression, but neither sufficient alone. The present research work was conducted design lens embedded with an atropine base within microemulsion system. goal improve the stability of facilitate release from lens, preventing rapid clearance observed drops. Two microemulsions, one pH 7.4 other 6.5, were developed using surfactant D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS), co-surfactant 400 (PEG 400), emulsifier Capmul MCM C8, base, phosphate-buffered saline (PBS). microemulsions kept at room temperature (21 °C) amount in checked periodically over year reverse-phase High Performance Liquid Chromatography (RPHPLC) determine stability. globule size formulations measured zetasizer. MiSight soaked for 24 h, loaded into released PBS by RPHPLC. ISO 10993-5 guidelines used measure vitro cytotoxicity lenses. more stable 6.5 (ME 6.5) less than 4 % degradation, compared 10 degradation 7.4). sizes ranged between 17-21 nm. absorbed4.25 ± 1.67 µg ME majority (3.52 0.03 µg) 2 h. However, elutes toxic human corneal epithelial cells (HCECs), reducing cell viability 5 after While amounts future studies are needed address toxicity issue.

Language: Английский

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Comparison of Myopic Progression and Quality of Life Wearing Either DIMs Lenses or Single‐Vision Myopia Correcting Spectacles

Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Purpose: To assess the efficacy of Defocus Incorporated Multiple Segments (DIMS) spectacle lens for myopia control and its impact on vision-related quality life in Chinese children over a 1-year period. Methods: This randomized double-blind prospective controlled clinical trial enrolled 176 myopic subjects aged between seven 14 years who were randomly assigned into DIMS group or single-vision (SV) group. Refractive error axial length measurements at baseline, three-, six-, nine-, 12-month follow-up visits monitored. The Quality Life Impact Correction (QIRC) questionnaire was used to evaluate baseline 12 months postintervention. Results: Of initial cohort, total 151 successfully completed study (DIMS n = 72; SV 79). Baseline characteristics similar both groups. Average elongation progression after 1 year 0.17 (95% CI 0.13-0.20) mm -0.27 -0.36 -0.18) D 0.30 0.26-0.33) -0.55 -0.64 -0.47) mean differences 0.13 0.08-0.18 mm, p < 0.001) -0.28 -0.41 -0.15 D, two No significant difference QIRC score found groups (55.30 53.17-56.90) versus 54.20 51.99-56.41), p=0.854)). Conclusion: use lenses slow down compared lenses, without negatively affecting their overall life. Trial Registration: Clinical Registry identifier: ChiCTR2000037443.

Language: Английский

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Peripheral refraction and aberrations in myopic eyes after small-incision lenticule extraction (SMILE) surgery

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 23, 2025

Language: Английский

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The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children

Translational Vision Science & Technology, Journal Year: 2025, Volume and Issue: 14(3), P. 8 - 8

Published: March 11, 2025

Purpose: This study aims to explore the impact of wearing peripheral defocus spectacle lenses (PDSL) on cylindrical refractive error (CYL) in myopic children. Methods: included 1057 children and divided participants into three groups: HAL group (spectacle lens with highly aspherical lenslets), MPV based manipulating vision), a control (without myopia interventions). The analyzed effect PDSL changes spherical equivalent refraction, CYL, corneal astigmatism (CA). mediating between errors (SPH) CYL was also investigated. Results: Compared (0.05 ± 0.33 D), annual progression faster (−0.15 D, P < 0.001) (−0.09 0.27 = 0.019). More had an ≥0.50 D (HAL: 23.6%, Control: 16.2%, 0.012). CA were consistent within groups 0.677, MPV: 0.683). total primarily due direct induction from indirect through SPH effect. Conclusions: application could cause increase children, which mainly be contributed cornea change. Translational Relevance: may passively affect anterior ocular biomechanics during control, leading astigmatism.

Language: Английский

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Myopia control efficacy of Asymmetric Multi-point Defocus Technique spectacle lenses: 1-year double-masked randomized controlled trial

Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Retinal “sweet spot” for myopia treatment

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 5, 2024

We studied which retinal area controls short-term axial eye shortening when human subjects were exposed to + 3.0D monocular defocus. A custom-built infrared tracker recorded the point of fixation while watched a movie at 2 m distance. The software accessed each individual frame in real-time and covered points with uniform grey patch. Four patches programmed: (1) foveal patch (0–3 degrees), (2) annular (3–9 deg), (3) deg) combined an (6–9 (4) full-field where only 6–10 deg Axial was elicited similarly positive defocus patch, indicating that fovea made minor contribution (-11 ± 12 μm vs. -14 17 μm, respectively, n.s.). In contrast, patching 3–9 degrees or together 6–9 degrees, completely suppressed effect compared (+ 3 1 -2 13 -11 p < 0.001). Finally, we found near-peripheral retina (6–10 degrees) is "sweet spot" for detection alone can regulate growth control mechanism, perhaps long-term refractive development (-9 8 full-field:

Language: Английский

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Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(2), P. 33 - 33

Published: Feb. 12, 2025

Purpose: The purpose of this study was to compare relative peripheral refraction (RPR) and axial growth in Chinese pediatric patients with cataract who underwent multifocal or monofocal intraocular lens (IOL) implantation. Methods: Pediatric aged 3 6 years IOL implantation from 2020 2021 were enrolled study. received implantations optic capture Berger's space. length (AL) measured a Zeiss Master 700, autorefraction at the horizontal retina within 30 degrees eccentricities recorded Grand Seiko WAM-5500 autorefractor. RPR calculated by subtracting central refraction. rate as change AL divided number follow-up years. Results: Twenty-six children (38 eyes) implanted IOLs 19 (30 completed No significant differences observed preoperative characteristics between two groups (P > 0.05). generalized estimating equation (GEE) model revealed that significantly associated type = 0.049) after adjusting for surgical age intervals, eyes showing lower annual than eyes. Additionally, compared eyes, exhibited greater myopic defocus 20 on temporal < 0.001 P 0.005, respectively). GEE also positive correlation 0.018). Conclusions: less growth, potentially caused defocus.

Language: Английский

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Advances in the study of ARR3 in myopia

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 11, 2025

The ARR3 gene (cone arrestin, OMIM: 301770) has gained significant attention as a pivotal factor in the etiology of myopia, particularly early-onset high myopia (eoHM). As member arrestin family, is predominantly expressed cone photoreceptors, playing crucial role visual processing. Recent studies have identified specific mutations that correlate with an elevated risk development, highlighting its potential involvement disease’s pathogenesis. This review summarizes current advancements elucidating relationship between and emphasizing genetic variations associated refractive errors their implications for research clinical management. We emphasize necessity further to elucidate regarding impact on development predisposition observed populations.

Language: Английский

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