Protective effects of flavonoid-rich extracts from Hibiscus sabdariffa leaves on streptozotocin-induced testicular damage in rats
Phytomedicine Plus,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100808 - 100808
Published: April 1, 2025
Language: Английский
Quercetin Ameliorates Testicular Damage in Zucker Diabetic Fatty Rats through Its Antioxidant, Anti-Inflammatory and Anti-Apoptotic Properties
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 16056 - 16056
Published: Dec. 16, 2022
The
aim
of
this
study
was
to
investigate
the
effects
quercetin
(QUE)
on
testicular
architecture
as
well
markers
oxidative,
inflammatory,
and
apoptotic
profile
male
gonads
in
Zucker
diabetic
fatty
(ZDF)
rats
suffering
from
Type
2
diabetes
mellitus
absence
or
presence
obesity.
QUE
administered
orally
at
a
dose
20
mg/kg/day
for
6
weeks.
Morphometric
analysis
revealed
that
treatment
led
an
improvement
appearance,
particularly
case
Obese
ZDF
rats.
Furthermore,
significant
stabilization
antioxidant
capacity
(p
<
0.05),
superoxide
dismutase
catalase
activity
0.01),
with
concomitant
decrease
lipid
peroxidation
0.05)
were
observed
animals
exposed
QUE.
Our
data
also
indicate
decline
levels
interleukin
(IL)-1
IL-6
0.01)
tumor
necrosis
factor
alpha
0.001)
following
supplementation
comparison
their
respective
control.
Finally,
down-regulation
pro-apoptotic
BAX
protein
0.0001)
QUE,
while
Bcl-2
overexpression
recorded
Lean
when
compared
untreated
As
such,
our
results
suggest
is
potentially
beneficial
agent
reduce
damage
by
decreasing
oxidative
stress,
chronic
inflammation,
excessive
cell
loss
through
apoptosis.
Language: Английский
Steroidogenic Enzyme Gene Expression and Testosterone Production are Developmentally Modulated by Bone Morphogenetic Protein Receptor-1B in Mouse Testis
Physiological Research,
Journal Year:
2023,
Volume and Issue:
72(3)
Published: June 30, 2023
Bone
morphogenetic
proteins
(BMPs)
and
receptors
(BMPR-1A,
BMPR-1B,
BMPR-2)
have
been
shown
to
be
vital
for
female
reproduction,
while
their
roles
in
males
are
poorly
described.
Our
study
was
undertaken
specify
the
function
of
BMPR-1B
steroidogenic
enzyme
gene
expression,
testosterone
production
reproductive
development
male
mice,
given
that
Bmpr1b
mRNA
is
expressed
mouse
testis
knockout
results
compromised
fertility.
Male
mice
were
passively
immunized
6
days
with
anti-BMPR-1B
presence
or
absence
exogenous
gonadotrophins.
We
then
measured
effects
on
testicular
hydroxysteroid
dehydrogenase
isoforms
(Hsd3b1,
Hsd3b6,
Hsd17b3)
aromatase
(Cyp19)
serum
levels,
seminal
vesicle
weight.
In
vitro
response
determined
using
culture,
Leydig
cell
culture
contribution
seminiferous
tubules
cells
examined
by
preconditioning
media
these
constituents.
adult
increased
Hsd3b1
but
decreased
Hsd3b6
Cyp19
mRNA.
tubule
conditioned
reduced
testosterone,
normal
it
levels.
pubertal
gonadotrophin
stimulated
growth.
conclusion,
has
specific
developmental
functions
autocrine
paracrine
regulation
expression
adults
vesicles
during
puberty.
Language: Английский
Nutritional value and chemical properties of drone milk as a source of probiotics and evaluation of antioxidant effects on reproductive structures by in vitro test
Miroslava Kačániová,
No information about this author
M Skultétyová,
No information about this author
Eva Tvrdá
No information about this author
et al.
Process Biochemistry,
Journal Year:
2024,
Volume and Issue:
149, P. 144 - 157
Published: Dec. 10, 2024
Language: Английский