Dialectics of perisomatic inhibition—The unity and conflict of opposites DOI Creative Commons
Andrei Rozov, David Jappy,

Ksenia Maltseva

et al.

Frontiers in Neural Circuits, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 29, 2024

Over the past three decades, a great deal of attention has been paid to study perisomatic inhibition and inhibitory basket cells. A growing body experimental evidence points leading role cells in generation oscillatory activity various frequency ranges. Recently link between complex behavior demonstrated several laboratories. However, all this is true only for one type interneuron-parvalbumin-positive Nevertheless, where parvalbumin-positive are found, there another cell, cholecystokinin-positive interneurons. These two types interneurons share number common features: they innervate same compartments target neurons often receive excitation from sources, but also differ each other synchrony their GABA release expression receptors. The functional not so obvious. They were thought be involved theta oscillations, however recent measurements free moving animals have put some doubts on hypothesis. Therefore, an important question is, whether these work synergistically or perform opposing actions networks? In mini-review, we attempt answer by putting forward idea that functionally united as entities network, necessary maintain rhythmogenesis "healthy", physiological range.

Language: Английский

Parvalbumin Interneuron Dysfunction in Neurological Disorders: Focus on Epilepsy and Alzheimer’s Disease DOI Open Access
Beulah Leitch

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5549 - 5549

Published: May 19, 2024

Parvalbumin expressing (PV+) GABAergic interneurons are fast spiking neurons that provide powerful but relatively short-lived inhibition to principal excitatory cells in the brain. They play a vital role feedforward and feedback synaptic inhibition, preventing run away excitation neural networks. Hence, their dysfunction can lead hyperexcitability increased susceptibility seizures. PV+ also key players generating gamma oscillations, which synchronized oscillations associated with various cognitive functions. interneuron particularly vulnerable aging degeneration has been decline memory impairment dementia Alzheimer’s disease (AD). Overall, of disrupts normal excitatory/inhibitory balance within specific neurocircuits brain thus linked wide range neurodevelopmental neuropsychiatric disorders. This review focuses on dysfunctional inhibitory generation epileptic seizures potential as targets design future therapeutic strategies treat these Recent research using cutting-edge optogenetic chemogenetic technologies demonstrated they be selectively manipulated control restore activity brains animal models. suggests could important developing treatments for patients epilepsy comorbid disorders, such AD, where directly deficits.

Language: Английский

Citations

11
GABA system as the cause and effect in early development DOI

Irina Topchiy,

Julie Mohbat,

Oluwarotimi Folorunso

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105651 - 105651

Published: April 4, 2024

Language: Английский

Citations

6
Aging-associated weakening of the action potential in fast-spiking interneurons in the human neocortex DOI Creative Commons
Viktor Szegedi,

Ádám Tiszlavicz,

Szabina Furdan

et al.

Journal of Biotechnology, Journal Year: 2024, Volume and Issue: 389, P. 1 - 12

Published: May 1, 2024

Aging is associated with the slowdown of neuronal processing and cognitive performance in brain; however, exact cellular mechanisms behind this deterioration humans are poorly elucidated. Recordings human acute brain slices prepared from tissue resected during surgery enable investigation changes age. Although neocortical fast-spiking cells widely implicated network activities underlying processes, they vulnerable to neurodegeneration. Herein, we analyzed electrical properties 147 interneurons neocortex samples 106 patients aged 11–84 years. By studying electrophysiological features action potentials passive membrane properties, report that potential overshoot significantly decreases spike half-width increases Moreover, maximum-rise speed (but not repolarization or afterhyperpolarization amplitude) changed age, suggesting a particular weakening sodium channel current generated soma. Cell measured as input resistance, time constant, cell capacitance remained unaffected by senescence. Thus, conclude shows significant This may contribute cortical functions aging.

Language: Английский

Citations

4
Impaired folate metabolism reshapes auditory response profiles and impairs loudness perception in MTHFR-deficient mice DOI Creative Commons

Hila Spair,

Ghattas Bisharat,

Hava M. Golan

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106863 - 106863

Published: March 1, 2025

Folate metabolism, regulated by methylenetetrahydrofolate reductase (MTHFR), is crucial for proper neurodevelopment, and disruptions-whether due to genetic polymorphisms or maternal nutritional deficits-have been linked cognitive behavioral impairments. Notably, MTHFR-deficient mouse models display altered social interaction auditory communication, hinting at disruptions in auditory-related circuits prompting the question of whether impaired folate metabolism might also affect sound processing perception. Here, using two-photon calcium imaging, we show that MTHFR deficiency increases both spontaneous sound-evoked activity cortex significantly shifts neuronal response profiles, which turn elevates perceived loudness while reducing sound-level discrimination. These findings underscore potential role compromised driving atypical responses may have broader relevance understanding sensory dysfunction various neurodevelopmental conditions.

Language: Английский

Citations

0
Perineuronal Nets: Role in Normal Brain Physiology and Aging, and Pathology of various Diseases DOI
Kejian Zhu, Yifei Fu, Yan Zhao

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 108, P. 102756 - 102756

Published: April 18, 2025

Language: Английский

Citations

0
Pyramidal and parvalbumin neurons modulate the process of electroacupuncture stimulation for stroke rehabilitation DOI Creative Commons
Xiaorong Tang,

Jiahui Shi,

Shu‐Min Lin

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(5), P. 109695 - 109695

Published: April 9, 2024

Electroacupuncture (EA) stimulation has been shown to be beneficial in stroke rehabilitation; however, little is known about the neurological mechanism by which this peripheral approach treats for stroke. This study showed that both pyramidal and parvalbumin (PV) neuronal activity increased contralesional primary motor cortex forelimb area (M1FL) after ischemic induced focal unilateral occlusion M1FL. EA reduced PV activity. These results were obtained a combination of fiber photometry recordings,

Language: Английский

Citations

3
Regulation of input excitability in human and mouse parvalbumin interneurons by Kir potassium channels DOI Creative Commons
Szabina Furdan,

Abdennour Douida,

Emőke Bakos

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Compared to rodents, inhibitory interneurons in the human neocortex exhibit high input excitability because of reduced passive ion leakage across their extracellular membrane. However, regulation intrinsic by voltage-gated channels activated over a wide range membrane potentials remains poorly understood. We performed whole-cell patch-clamp microelectrode recordings mouse and neocortical slices obtained from surgically resected non-pathological brain tissue finding that Kir control electrical resistance parvalbumin (Pvalb) neurons an identical manner mouse. Molecular analyses revealed predominantly Kir3.1 Kir3.2 Pvalb both species. Using synaptically connected neuron pairs computational model, we demonstrated physiological activation inhibits during postsynaptic evoked presynaptic neurogliaform cells. The similarity Kir-mediated inhibition species suggests it is archetypal property neurons.

Language: Английский

Citations

0
Candidate Key Proteins in Tinnitus—A Bioinformatic Study of Synaptic Transmission in the Cochlear Nucleus DOI Creative Commons

Johann Gross,

Marlies Knipper, Birgit Mazurek

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1615 - 1615

Published: July 19, 2024

The aim of this study was to identify key proteins synaptic transmission in the cochlear nucleus (CN) that are involved normal hearing, acoustic stimulation, and tinnitus. A gene list compiled from GeneCards database using keywords "synaptic transmission" AND "tinnitus" "cochlear nucleus" (Tin). For comparison, two lists with "auditory perception" (AP) "acoustic stimulation" (AcouStim) were built. STRING protein-protein interaction (PPI) network Cytoscape data analyzer used top high-degree (HDPs) their high-score (HSIPs), together referred as proteins. top1 Tin-process BDNF, NTRK1, NTRK3, NTF3; top2 FOS, JUN, CREB1, EGR1, MAPK1, MAPK3. Highly significant GO terms CN tinnitus "RNA polymerase II transcription factor complex", "late endosome", cellular response cadmium ion", "cellular reactive oxygen species", "nerve growth signaling pathway", indicating changes vesicle cell homeostasis. In contrast spiral ganglion, where important characterized by processes at level cells, biological take place synapses transcription.

Language: Английский

Citations

1
Cortical inhibitory parvalbumin interneurons exhibit metabolic specializations coordinated by PGC-1α that are lost in rodents and humans after traumatic brain injury DOI Open Access

Sadi Quiñones,

Jason C Wang,

Elliot Kim

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 23, 2024

Abstract Parvalbumin-positive interneurons (PV-INs) regulate neuronal and circuit activity, their dysfunction is observed across neurological conditions, including traumatic brain injury (TBI), epilepsy, Alzheimer’s disease, schizophrenia. PV-INs are particularly vulnerable to cell loss, potentially due increased metabolic demands arising from uniquely high level of electrical which render them susceptible pressure. Here, we use single-nucleus RNA-sequencing (snRNAseq) data a rodent model TBI, as well human TBI data, demonstrate have unique specializations that lost after can be rescued by in vivo treatment with the glycolytic inhibitor, 2-deoxyglucose. We generated novel PV-IN transcriptional identity module comprised primarily genes encoding specialized ion channels, enzymes, synaptic machinery, identifies heterogenous subsets injury-associated loss identity. show changes specialization coupled implicate PV-IN-enriched co-activator, Ppargc1a , key driver dysfunction. also identify family long non-coding RNAs enriched this subset transcriptionally dysfunctional negatively correlates specialization. Lastly, utilize these tools interrogate published snRNAseq set find nearly identical changes, underscoring importance pathology TBI.

Language: Английский

Citations

0
Differences in motor learning-related structural plasticity of layer 2/3 parvalbumin-positive interneurons of the young and aged motor cortex DOI Creative Commons
Andrew M. Davidson,

Hernán Mejía-Gómez,

Bryn M Wooten

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Language: Английский

Citations

0