L-Arginine and Nitric Oxide in Vascular Regulation—Experimental Findings in the Context of Blood Donation
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(4), P. 665 - 665
Published: Feb. 13, 2025
This
narrative
review
provides
an
analysis
of
the
role
nitric
oxide
(NO)
and
its
precursors,
particularly
L-arginine,
in
vascular
regulation
health,
with
emphasis
on
findings
from
our
experimental
research
animal
models.
NO
serves
as
a
critical
mediator
function,
contributing
to
vasodilation,
blood
flow,
prevention
thrombosis.
As
primary
precursor
NO,
L-arginine
is
essential
for
maintaining
endothelial
integrity,
modulating
mitochondrial
reducing
oxidative
damage.
synthesises
data
contextualises
these
within
physiological
challenges
faced
by
donors,
such
repeated
donation
associated
stress.
It
examines
effects
supplementation
respiration,
lipid
peroxidation,
microsomal
oxidation
different
conditions,
including
differences
age,
gender,
dietary
interventions.
The
mechanisms
which
enhances
production,
improves
elasticity,
alleviates
dysfunction
caused
reduced
bioavailability
are
also
investigated.
By
integrating
insights
existing
literature,
this
perspective
potential
address
specific
needs
donors.
highlights
importance
personalised
nutritional
approaches
enhancing
donor
recovery
resilience.
In
addition,
assesses
wider
implications
mitigating
stress
preserving
function.
interplay
between
bioavailability,
factors,
adaptation
donors
highlighted,
along
identification
current
knowledge
gaps
recommendations
future
research.
presenting
both
original
evidence
synthesis
article
therapeutic
promoting
health
context
donation.
Language: Английский
L-Arginine and Intermittent Hypoxia Are Stress-Limiting Factors in Male Wistar Rat Models
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12364 - 12364
Published: Nov. 18, 2024
The
aim
of
this
study
was
to
evaluate
the
combined
effects
L-arginine,
intermittent
hypoxia
training
(IHT),
and
acute
stress
on
oxygen-dependent
processes
in
rats,
including
mitochondrial
oxidative
phosphorylation,
microsomal
oxidation,
intensity
lipoperoxidation
processes.
In
addition,
our
investigated
how
modulatory
effect
NO
synthase
mechanism
concentration
catecholamines
(CA),
such
as
adrenaline
noradrenaline,
their
biosynthetic
precursors
(DOPA,
dopamine)
varies
depending
cholinergic
(acetylcholine,
Ach-acetylcholinesterase,
AChE)
status
rats.
This
protective
stress-limiting
L-arginine
impact
IHT
blood
liver
results
showed
that
promoted
maintenance
NAD-dependent
oxidation
mitochondria,
which
detrimental
compared
succinate
accompanied
by
depletion
respiratory
activity
reserves
under
induced
high
concentrations
CA.
interdependence
SC-dependent
functional
role
substrate
chain
conditions
using
inhibitors
revealed
importance
system.
Administration
during
course
prior
exposure
increased
compensatory
capacity
organism.
sympathoadrenal
system
stress-exposed
early
stages
IHT,
modulation
CA
observed
with
a
concomitant
increase
processes,
final
increased,
but
there
also
an
inhibition
lipoperoxidation,
particularly
enhanced
administration
L-arginine.
ACh
decrease
AChE
at
different
adaptation
(days
5,
10,
14).
Thus,
method
significantly
mobilises
reserve
through
CA,
ACh-AChE
mediated
nitric
oxide.
Language: Английский