Gut microbiota dysbiosis induced by alcohol exposure in pubertal and adult mice DOI Creative Commons
Jinlong Yang, Haoyu Wang, Xiaoqian Lin

et al.

mSystems, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Alcohol intake causes many diseases including neuropsychiatric symptoms, nutritional deficiency, progressive pancreatitis, liver cirrhosis, and ischemic heart disease. The gut microbiota changes significantly after alcohol exposure. consumption tends to increase in underage young people, but the feature of puberty remains largely unexplored. In this study, we conducted alcohol-exposed pubertal adult mice model investigate intestinal damage change. Interestingly, responses exposure were different. We found that dehydrogenase decreased aldehyde increased mice, thus reducing accumulation toxic acetaldehyde. Furthermore, caused less injury mice. Through analysis metagenome assembly genome, obtained unrecognized bacterial genomes.

Language: Английский

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction DOI Creative Commons
Yousef Tizabi, Bruk Getachew, Sheketha R. Hauser

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 558 - 558

Published: May 30, 2024

Mood disorders and substance use disorder (SUD) are of immense medical social concern. Although significant progress on neuronal involvement in mood reward circuitries has been achieved, it is only relatively recently that the role glia these attracted attention. Detailed understanding glial functions devastating diseases could offer novel interventions. Here, following a brief review involved regulation perception, specific contributions neurotrophic factors, neuroinflammation, gut microbiota to highlighted. In this context, cells (e.g., microglia, astroglia, oligodendrocytes, synantocytes) phenotypic manifestation or SUD emphasized. addition, knowledge potential development therapeutics touched upon.

Language: Английский

Citations

13
Role of Nutrition in the Management of Inflammatory Bowel Disease DOI Creative Commons

Khalid Nawaz,

Atsushi Ito, Muneeb Ullah

et al.

Recent Progress in Nutrition, Journal Year: 2025, Volume and Issue: 05(01), P. 1 - 76

Published: Jan. 10, 2025

The persistent inflammation of the intestinal mucosa is main characteristic inflammatory bowel disease (IBD), a lifelong illness that affects people both genders. exact etiology still undefined while previously it was attributed to genetic components. Later, investigated environment has an equal effect on development IBD encompassing Crohn’s (CD) and Ulcerative colitis (UC). Among environmental risk factors linked IBD, diet, notably transition toward Western most noticeable element contributes IBD. This comprehensive overview summarizes present literature role food groups in nutrition management. Increased consumption sugar, fats, and/or proteins, decreased fruits vegetables, increased use emulsifiers or other binding compounds are among significant candidates lead intestines healthy individuals. Furthermore, low dietary habits, including selective malnutrition, obesity, sarcopenia, with poor clinical results, treatment responsiveness, and, as result, quality life. Therefore, trend management shifted therapies strategies like Specific Carbohydrate Diet (SCD), Mediterranean diet (MD), Enteral Nutrition (EN), exclusion (CDED), Inflammatory disease-Anti-inflammatory (IBD-AID), others reported have had positive association reducing underlying symptoms remission homeostasis.

Language: Английский

Citations

1
Diet-Gut Microbiome Nexus: A New Paradigm in Food-Based Mental Disease Therapeutics DOI
Sakshi Anand, Pradeep Kumar,

Sevaram Singh

et al.

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: March 19, 2025

Language: Английский

Citations

0
Role of glial cells in neurotoxicological effects of alcohol DOI
Yousef Tizabi, Bruk Getachew, Michael Aschner

et al.

Advances in neurotoxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Role of Glial Cells in Depression and Drug Addiction DOI Open Access
Yousef Tizabi, Bruk Getachew, Sheketha R. Hauser

et al.

Published: May 3, 2024

Major depressive disorder (MDD) and substance use (SUD) are of immense medical social concerns. Although significant progress on neuronal involvement in mood reward circuitries has been achieved, only relatively recently the role glia these disorders have attracted attention. Detail understanding glial function devastating diseases could offer novel interventions. Here, following a brief review involved regulation perception, specific contribution neurotrophic factors, neuroinflammation gut microbiota to highlighted. In this context, cells (e.g., microglia, astroglia, oligodendrocytes synantocytes) phenotypic manifestation MDD or SUD emphasized. addition, potential knowledge developing therapeutics is touched upon.

Language: Английский

Citations

1
Gut microbiota dysbiosis induced by alcohol exposure in pubertal and adult mice DOI Creative Commons
Jinlong Yang, Haoyu Wang, Xiaoqian Lin

et al.

mSystems, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Alcohol intake causes many diseases including neuropsychiatric symptoms, nutritional deficiency, progressive pancreatitis, liver cirrhosis, and ischemic heart disease. The gut microbiota changes significantly after alcohol exposure. consumption tends to increase in underage young people, but the feature of puberty remains largely unexplored. In this study, we conducted alcohol-exposed pubertal adult mice model investigate intestinal damage change. Interestingly, responses exposure were different. We found that dehydrogenase decreased aldehyde increased mice, thus reducing accumulation toxic acetaldehyde. Furthermore, caused less injury mice. Through analysis metagenome assembly genome, obtained unrecognized bacterial genomes.

Language: Английский

Citations

0