Nutritional Factors and Therapeutic Interventions in Autism Spectrum Disorder: A Narrative Review

Children, Journal Year: 2025, Volume and Issue: 12(2), P. 202 - 202

Published: Feb. 8, 2025

Objective: To explore recent findings on how nutritional, gastrointestinal, social, and epigenetic factors interact in autism spectrum disorder, highlighting their implications for clinical management intervention strategies that could improve development quality of life affected children. Sources: Studies published from 2000 to 2024 the PubMed, Web Science, Scopus, Scielo, Lilacs, Google Scholar databases were collected. The process review adhered Search, Appraisal, Synthesis, Analysis framework. Summary findings: Children with disorder have restrictive eating habits often exhibit food selectivity either hyper- or hypo-sensory characteristics. This provides an overview literature diagnosis including involvement family members meals, sharing a healthy diet positive relationship food, importance exploring visual, olfactory, tactile experiences introducing new foods through play activities expand repertoire. Modifications microbiota gastrointestinal disorders may also be present are presented due frequent nutritional repercussions. medium long-term preferences behavior issues status discussed, given tendency children consume low-quality energy-dense foods, leading problems. Conclusions: feeding difficulties, especially selectivity, problems, changes can evolve micronutrient deficiencies, malnutrition obesity. describes evidence possible targets interventions aiming health disorder.

Language: Английский

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Revised Swedish infant feeding guidelines are associated with earlier introduction of allergenic foods

Journal of Allergy and Clinical Immunology, Journal Year: 2023, Volume and Issue: 153(2), P. 461 - 470

Published: Oct. 7, 2023

BackgroundRandomized controlled trials have demonstrated that early introduction of allergenic foods, such as peanut and egg, can reduce food allergy in high-risk children. Many international guidelines recommend foods the first year life, accordingly, Swedish National Food agency released updated June 2019.ObjectiveOur aim was to examine whether age at consumption frequency changed since release revised national on solid Sweden.MethodsChildren born between 2016 December 2018 (n = 1925) were compared with children 2019 April 2021 1761) by using data from NorthPop Birth Cohort study. Data introduction, eczema, prospectively collected until 18 months web-based questionnaires. IgE sensitization assessed months.ResultsThe proportion participants who had been introduced legume, soy products, peanut, almond, cashew nut during life increased after implementation guidelines. The most significant changes seen for legume (from 55.2% 69.8% [adjusted odds ratio 1.90 (95% CI 1.62-2.24)] 29.2% 43.2% adjusted 1.87 1.55-2.24)]); also increased. No differences prevalence allergy, or interest found.ConclusionSince guidelines, infants general population are consume a variety earlier more frequently; however, manifestations allergic disease remained unchanged. Randomized 2019. Our Sweden. Children months. found. Since

Language: Английский

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Dissecting the Immune System through Gene Regulation

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 219 - 235

Published: Jan. 1, 2024

Language: Английский

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Maternal influences on offspring food allergy

Immunological Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Summary The prevalence of allergies has been globally escalating. While could appear at any age, they often develop in early life. However, the significant knowledge gap field is mechanisms by which affect certain people but not others. Investigating factors and events neonatal life that have a lasting impact on determining susceptibilities children to area investigation as it promotes understanding immune system mediates tolerance versus allergies. This review focuses research over recent 10 years regarding potential maternal influence offspring with view food allergy, potentially life‐threatening cause anaphylaxis. role breast milk, diet, antibodies, microbiota suggested key regulating are discussed here. We also suggest future expand our maternal–offspring interactions pathogenesis allergy.

Language: Английский

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Dietary strategies for early immune modulation in primary food allergy prevention

BMJ Nutrition Prevention & Health, Journal Year: 2023, Volume and Issue: 6(Suppl 3), P. s8 - s19

Published: Dec. 1, 2023

As the global incidence of food allergies continues to rise, effective primary prevention strategies remain a public health priority. Eczema in early infancy is major risk factor for IgE-mediated allergies. Exposure allergens via inflamed skin promotes cascade allergic immune responses and increases By contrast, exposure gut likely induce oral tolerance. Landmark studies have demonstrated significant reduction egg peanut allergy response dietary introduction allergens. result, feeding guidelines countries with high shifted from recommending prolonged allergen avoidance policy around 6 months age, as part diverse complementary diet. Uncertainties regarding optimum timing specific allergens, well minimum frequency dose. Exclusive breast months, continuation 2 years, generally recommended but does not appear consistently prevent Perinatal intermittent supplementary cow’s milk-based formula may increase milk protein allergy. Maternal during pregnancy lactation effective. However, maternal consumption appears their preventive effect infant conjunction into Data on supplementation pregnant women, breastfeeding mothers infants vitamin D, omega-3 polyunsaturated fatty acids, prebiotics or probiotics purpose are insufficient make firm clinical recommendations. In eczema, combination regular emollient treatment additive effects, trials so far had mixed outcomes. Further combining interventions aiming restore disrupted barrier eczema provide new insights at-risk populations.

Language: Английский

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Zéro allergie research clinic: a clinical and research initiative in oral immunotherapy for managing IgE-mediated food allergy

Allergy Asthma and Clinical Immunology, Journal Year: 2024, Volume and Issue: 20(1)

Published: Nov. 2, 2024

The Zéro allergie research clinic (Saguenay, Canada) is a clinical and initiative in oral immunotherapy (OIT) for managing IgE-mediated food allergy (FA). A total of 183 children with FA 27 non-allergic siblings were recruited to date the cohort (ZAC) better understand biological mechanisms underlying OIT prognosis. primary aims are (a) genetic, epigenetic, transcriptomic, metabolomic, microbial diversity associated FA; (b) establish multi-omics profiles following identify predictive prognosis biomarkers, (c) make more accessible population Saguenay-Lac-Saint-Jean region, (d) build biobank data material.

Language: Английский

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Allergic Disease - New Developments in Diagnosis and Therapy

IntechOpen eBooks, Journal Year: 2022, Volume and Issue: unknown

Published: July 12, 2022

This book provides a comprehensive overview of allergies, ranging from environmental allergies to food allergies. It discusses the diagnosis and management allergic reactions, including early exposure allergens, immunotherapy, stem cell treatment. includes eight chapters organized into four sections. Chapters discuss some most frequent diseases, such as atopic dermatitis chronic urticaria. There is also chapter dedicated treating during COVID-19 pandemic.

Language: Английский

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Introductory Chapter: Allergic Disease – New Developments in Diagnosis and Therapy

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: April 12, 2023

Language: Английский

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