French Guiana and AGS: a path to uncovering hidden clues

Expert Review of Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Introduction This article is a narrative review exploring how research in French Guiana could unlock the mysteries surrounding Alpha-Gal Syndrome (AGS), recently identified IgE-mediated allergy with delayed reactions to exposure non-Catarrhine mammalian-derived products. Although fewer than 10 cases have been reported across Latin America, two case series involving 11 and 18 patients AGS documented Guiana.

Language: Английский

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The Acari Hypothesis, VII: accounting for the comorbidity of allergy with other contemporary medical conditions, especially metabolic syndrome

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 6

Published: March 27, 2025

The Acari Hypothesis proposes that vector-active acarians, i.e., mites and ticks, are the etiologic agents responsible for most, if not all, allergies. A corollary of posits allergies now more prevalent because contemporary hygienic practices remove from skin elements sweat otherwise deter acarians. Because antimicrobial activity extends beyond disruption/removal on/from must enable aberrant microbial colonization, possibly potentiating comorbid conditions assignable to colonist(s). Allergy is strongly with metabolic syndrome. Available evidence links principal features syndrome Staphylococcus aureus , an organism influenced significantly by constituents sweat. Thus, removal predisposes both allergy Indeed, “immune-compromised” state brought upon likely accounts comorbidity many medical conditions, examples which highlighted.

Language: Английский

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The Acari Hypothesis, V: deciphering allergenicity

Frontiers in Allergy, Journal Year: 2024, Volume and Issue: 5

Published: Nov. 1, 2024

The Acari Hypothesis posits that acarians, i.e., mites and ticks, are operative agents of allergy. It derived from observations allergens molecular elements acarians or acarian foodstuffs. A corollary provides how dietary selected as allergens; namely, a pattern recognition receptor native to the digestive tract complexes with molecules problematic acarian. By virtue its interspecies operability, then enables not only removal by immune system, but also-should such complex be inoculated into human-production an element-specific IgE. Because receptors bind organism which originate, it follows targeted adaptive IgE, allergens, must acarians. This claim is supported evidence host organisms, when infested upregulate representative members allergenic families. Appreciation relationship between insight well beyond allergy, shedding light also on anti-acarian defenses many living things, especially humans.

Language: Английский

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The Acari Hypothesis, VI: human sebum and the cutaneous microbiome in allergy and in lipid homeostasis

Frontiers in Allergy, Journal Year: 2024, Volume and Issue: 5

Published: Nov. 21, 2024

The Acari Hypothesis posits that acarians, i.e., mites and ticks, are causative agents of IgE-mediated conditions. This report further develops Hypothesis, providing rationale for the childhood predilection allergy. In short,

Language: Английский

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One health: the impact of environment, detergents and hygiene on barrier, microbiome and allergy

Allergo Journal International, Journal Year: 2024, Volume and Issue: 33(7), P. 252 - 262

Published: Oct. 9, 2024

Summary A variety of body surfaces, such as skin and mucosal membranes—from the nasopharyngeal area to lungs, uterus, vaginal area, digestive tract—contain complex microbial ecosystems that are tailored specifics respective niche [1]. The so-called dysbiosis—a disadvantageous change in composition microbiome—is associated with pathogenesis a diseases [2]. Gastrointestinal well cardiovascular, metabolic, neurodegenerative, psychological, oncological, also allergic have been linked dysbiosis. Susceptibility allergies can be due genetic predisposition; addition, extrinsic factors from today’s lifestyle increasingly contribute microbiome changes, but disruption barrier thus development [3]. Gisela, fictional farmer, guides us through this review. She is representative adults children all genders industrialized countries. During her daily routine, influenced by exogenous factors. These include everyday personal hygiene products, detergents for laundry dishes, food, medication, animal contact, exposure various outdoor environments. Gisela’s routine will illustrate how human modified positive or negative ways, could influence allergies. Furthermore, potential measures prevention management dysbiosis discussed terms examples alternative products behaviors.

Language: Английский

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One health: der Einfluss von Umwelt, Detergenzien und Hygiene auf Barriere, Mikrobiom und Allergie

Allergo Journal, Journal Year: 2024, Volume and Issue: 33(7), P. 22 - 33

Published: Oct. 31, 2024

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