Modern treatment methods in atopic dermatitis - literature overview DOI Creative Commons

Martyna Borowska-Łygan,

J E Tomaszewski,

Wojciech Urban

et al.

Journal of Education Health and Sport, Journal Year: 2025, Volume and Issue: 77, P. 56830 - 56830

Published: Jan. 3, 2025

Introduction and aim: Atopic dermatitis (AD) is a chronic inflammatory skin disease. It characterised by periods of exacerbation remission symptoms such as pruritus, dry eczematous lesions with characteristic morphology. The aim this study to present the current state knowledge on new treatments for atopic dermatitis. Review methods: review was based publicly available PubMed Google Scholar databases from 2020 2024 using following phrases: dermatitis, treatment diagnosis epidemiology, biological JAK inhibitors, stem cells, Brief description art: disease whose mechanism origin incompletely understood.It involves interactions between genotype, environment, immune system, largely related T-cell response. main symptom pruritus leading lichenification or exfoliation epidermis, which characterise form. Diagnosis confirmed clinical criteria AD, family predisposition allergic full history tests. Treatment focuses managing associated improving patient's quality life mainly corticosteroids, calcineurin inhibitors antihistamines. Recent studies show positive effects biologic drugs, cells provide great hope towards development Summary: authors emphasise need further research promising, innovative in order significantly improve patients' life.

Language: Английский

Serum Lipids Alterations in Patients Under Systemic JAK Inhibitors Treatments in Dermatology: Clinical Aspects and Management DOI Creative Commons
Giovanni Paolino, Mario Valenti, Andrea Carugno

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(1), P. 54 - 54

Published: Jan. 1, 2025

Background and Objectives: Janus kinase inhibitors (JAKi) have significantly advanced the treatment of various dermatological conditions by modulating JAK-STAT signalling pathway. While these proven effective, they also pose challenges due to associated increase in serum lipid levels relative potential cardiovascular risks. This perspective work aims discuss implications alterations proposing management strategies for patients with disorders under JAKi treatments. Materials Methods: manuscript reviews existing recent literature on metabolic effects JAKi, particularly focusing their impact profiles treated diseases. Results: JAK are consistently an both LDL HDL shortly after initiation, which tend stabilise over time. Despite changes, there is no clear evidence linking increased risk major adverse events (MACE), indicating a complex interaction between metabolism signalling. Conclusions: Although may induce changes patients, raising concerns, especially ones risks, currently link MACE this population. Monitoring levels, alongside lifestyle modifications possible statin use, can manage without need stopping treatment.

Language: Английский

Citations

0
Modern treatment methods in atopic dermatitis - literature overview DOI Creative Commons

Martyna Borowska-Łygan,

J E Tomaszewski,

Wojciech Urban

et al.

Journal of Education Health and Sport, Journal Year: 2025, Volume and Issue: 77, P. 56830 - 56830

Published: Jan. 3, 2025

Introduction and aim: Atopic dermatitis (AD) is a chronic inflammatory skin disease. It characterised by periods of exacerbation remission symptoms such as pruritus, dry eczematous lesions with characteristic morphology. The aim this study to present the current state knowledge on new treatments for atopic dermatitis. Review methods: review was based publicly available PubMed Google Scholar databases from 2020 2024 using following phrases: dermatitis, treatment diagnosis epidemiology, biological JAK inhibitors, stem cells, Brief description art: disease whose mechanism origin incompletely understood.It involves interactions between genotype, environment, immune system, largely related T-cell response. main symptom pruritus leading lichenification or exfoliation epidermis, which characterise form. Diagnosis confirmed clinical criteria AD, family predisposition allergic full history tests. Treatment focuses managing associated improving patient's quality life mainly corticosteroids, calcineurin inhibitors antihistamines. Recent studies show positive effects biologic drugs, cells provide great hope towards development Summary: authors emphasise need further research promising, innovative in order significantly improve patients' life.

Language: Английский

Citations

0