Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

Food Hypersensitivity: Distinguishing Allergy from Intolerance, Main Characteristics, and Symptoms—A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1359 - 1359

Published: April 16, 2025

Background/Objectives: Food hypersensitivity remains an understudied and overlooked subject globally. It is characterized by adverse reactions to dietary substances, potentially triggered various mechanisms. allergy, a subset of food hypersensitivity, denotes immune response proteins categorized into immunoglobulin IgE-mediated or non-IgE-mediated reactions. Conversely, intolerance, another facet refers non-immunological reactions, in which the human body cannot properly digest certain foods components, leading gastrointestinal discomfort other non-immune-related symptoms. The main objective this study was determine differentiate differences, characteristics, types hypersensitivity. Methods: This involved comprehensive review key research from 1990 onward, including articles, prospective studies, nested case–control meta-analyses. Results: Recognizing these differences essential for healthcare professionals ensure accurate diagnosis, effective management, improved patient outcomes, while also aiding dietitians providing optimal nutritional guidance. Conclusions: there are big between such as symptoms, complications, treatments allergies, intolerances. Commonly reported trigger include cow milk, gluten, eggs, nuts, seafood.

Language: Английский