Heterozygosity-Rich Regions in Canine Genome: Can They Serve as Indicators of Balancing Selection?

Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 612 - 612

Published: Feb. 19, 2025

Compared to the negative effect of directional selection on genetic diversity, balancing acts oppositely and maintains variability across genome. This study aims articulate whether leads heterozygosity-rich region islands (HRRIs) forming in canine genome by investigating 1000 animals belonging 50 dog breeds via 153,733 autosomal SNPs. A consecutive SNP-based approach was used identify regions (HRRs). Signals studied were then assessed with Tajima's D statistics. total 72,062 HRRs an average length 324 kb detected be unevenly distributed 509 450 genomic classified as HRRIs signals, respectively. Although genome-wide distributions varied breeds, several found same locations multiple breeds. 109 both signals selection. Even though coordinates did not fully overlap all regions, may play a significant role maintaining diversity associated various cancer diseases, immune response, bone, skin, cartilage tissue development.

Language: Английский

Genome-Wide Patterns of Homozygosity and Heterozygosity and Candidate Genes in Greek Insular and Mainland Native Goats

Genes, Journal Year: 2024, Volume and Issue: 16(1), P. 27 - 27

Published: Dec. 27, 2024

Runs of homozygosity (ROHs) and heterozygosity (ROHets) serve for the identification genomic regions as candidates selection, local adaptation, population history. The present study aimed to comprehensively explore ROH ROHet patterns hotspots in Greek native dairy goats, Eghoria Skopelos, genotyped with Illumina Goat SNP50 BeadChip. SNP functional enrichment analyses were conducted further characterize candidate genes located within these regions. Genetic relationships between breeds inbreeding coefficients also evaluated. Clear genetic differentiation diversified management practices depicted two populations. average genome coverage Skopelos (65.35 35 Mb) (47.64 43 indicated differences mainland insular showing more long fragments, reflecting its geographic isolation small size. An hotspot (CHR12: 43.59-44.61 detected has been reported across European goats co-localizes a selection signal Egyptian Barki sheep adapted hot-arid conditions. A novel (CHR18: 60.12-61.81 Mb), shared among breeds, harbors enriched biosynthesis, metabolism, immune response. Two well-conserved islands on chromosomes 1 18, participating development embryogenesis. showed highest number islands, potentially adaptability diverse environments. These findings offer new insights into environmental adaptation artificial could be utilized future breeding strategies sustainable goat farming.

Language: Английский