Diamond and Related Materials, Journal Year: 2023, Volume and Issue: 140, P. 110494 - 110494
Published: Oct. 12, 2023
Language: Английский
Diamond and Related Materials, Journal Year: 2023, Volume and Issue: 140, P. 110494 - 110494
Published: Oct. 12, 2023
Language: Английский
Environmental Research, Journal Year: 2023, Volume and Issue: 236, P. 116850 - 116850
Published: Aug. 7, 2023
Language: Английский
Citations
15South African Journal of Botany, Journal Year: 2023, Volume and Issue: 155, P. 127 - 139
Published: Feb. 20, 2023
Language: Английский
Citations
14Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(4)
Published: June 11, 2024
The Varicella-zoster virus (VZV), classified as a neurotropic member of the Herpesviridae family, exhibits characteristic pathogenicity, predominantly inducing varicella, commonly known chickenpox, during initial infectious phase, and triggering reactivation herpes zoster, more recognized shingles, following its emergence from latent state. pathogenesis VZV-associated neuroinflammation involves complex interplay between viral replication within sensory ganglia immune-mediated responses that contribute to tissue damage dysfunction. Upon primary infection, VZV gains access ganglia, establishing infection neurons. During reactivation, can spread along nerves, cascade inflammatory mediators, chemokines, immune cell infiltration in affected neural tissues. role both adaptive innate reactions, including contributions T B cells, macrophages, dendritic orchestrating central nervous system is elucidated. Furthermore, aberrant activation natural defence mechanism, characterised by dysregulated production immunomodulatory proteins has been implicated VZV-induced neurological disorders, such encephalitis, myelitis, vasculopathy. intricate balance protective detrimental context emphasises necessity for an exhaustive comprehension immunopathogenic mechanisms propelling neuroinflammatory processes. Despite availability vaccines antiviral therapies, VZV-related complications remain significant concern, particularly immunocompromised individuals elderly. Elucidating these might facilitate innovative strategies targeted therapies aimed at mitigating improving clinical outcomes. This comprehensive understanding enhances our grasp holds promise pioneering therapeutic designed mitigate ramifications infections.
Language: Английский
Citations
6Engineering Applications of Artificial Intelligence, Journal Year: 2024, Volume and Issue: 135, P. 108794 - 108794
Published: June 14, 2024
Language: Английский
Citations
6Diamond and Related Materials, Journal Year: 2023, Volume and Issue: 140, P. 110494 - 110494
Published: Oct. 12, 2023
Language: Английский
Citations
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