The Neuroscience Journal of Shefaye Khatam, Journal Year: 2023, Volume and Issue: 12(1), P. 111 - 120
Published: Dec. 1, 2023
Language: Английский
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 298 - 312
Published: June 3, 2024
Language: Английский
Citations
11
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 6, 2025
Recovery from spinal cord injury (SCI) is often impeded by neuroinflammation, scar formation, and limited axonal regeneration. To tackle these issues, we developed an innovative biomimetic drug delivery system using liquid nitrogen-treated M2 macrophages (LNT M2) which internalized paclitaxel (PTX) nanoparticles beforehand. These were incorporated into a gelatin methacryloyl (GelMA) scaffold, creating multifunctional, injectable treatment for single-dose administration. The LNT inherited the inflammatory factor/chemokine receptors living thus possessing significant neutralizing effect. In addition, scaffold provides slow, sustained release of PTX, promoting regeneration suppressing formation in SCI rats. M2-based dual-functional significantly enhances motor function, reduces accelerates modulating microenvironment preventing glial fibrotic scars. This approach combines regenerative effects low-dose PTX with immunoregulatory properties M2, leading to remarkable neurological recovery Moreover, scaffold's straightforward preparation, ease standardization, "ready-to-use" nature make it promising candidate acute intervention future clinical applications.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 723 - 723
Published: Jan. 16, 2025
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising therapeutic strategy for spinal cord injury (SCI). These nanosized possess unique properties such low immunogenicity and the ability to cross biological barriers, making them ideal carriers delivering bioactive molecules injured tissues. MSC-EVs been demonstrated exert multiple beneficial effects in SCI, including reducing inflammation, promoting neuroprotection, enhancing axonal regeneration. Recent studies delved into molecular mechanisms underlying MSC-EV-mediated effects. Exosomal microRNAs (miRNAs) identified key regulators of various cellular processes involved SCI pathogenesis repair. miRNAs can influence oxidative stress, apoptosis by modulating gene expression. This review summarized current state MSC-EV-based therapies highlighting potential clinical applications. We discussed challenges limitations translating these practice, inconsistent EV production, complex cargo composition, need targeted delivery strategies. Future research should focus on optimizing production characterization, identifying miRNAs, developing innovative systems maximize SCI.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 13849 - 13849
Published: Sept. 8, 2023
Neurological disorders represent a global health problem. Current pharmacological treatments often lead to short-term symptomatic relief but have dose-dependent side effects, such as inducing orthostatic arterial hypotension due the blockade of alpha receptors, cardiotoxic effects impaired repolarization, and atrioventricular block tachycardia, including ventricular fibrillation. These challenges driven medical community seek effective for this serious threat. Mesenchymal stem cells (MSCs) are pluripotent with anti-inflammatory, anti-apoptotic, immunomodulatory properties, providing promising alternative their ability differentiate, favorable culture conditions, in vitro manipulation ability, robust properties. Although MSCs themselves rarely differentiate into neurons at site injury after transplantation vivo, paracrine factors secreted by can create environmental conditions cell-to-cell communication shown therapeutic effects. Recent studies that pleiotropic MSCs, particularly potential, be attributed primarily these factors. Exosomes derived from known play an important role Many evaluated potential exosome-based therapies treatment various neurological diseases. In addition exosomes, miRNAs been identified regulate genes alleviate neuropathological changes neurodegenerative This review explores burgeoning field therapies, focusing on MSC-derived exosomes exosomal miRNAs, summarizes recent findings shed light disorders. The insights gained may pave way innovative complex conditions. Furthermore, we suggest which rescue spinal cord via diverse signaling pathways.
Language: Английский
Citations
14
Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)
Published: May 13, 2024
Abstract Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), and traumatic brain injury (TBI) exemplify complexities diversities complicate their early detection development effective treatments. Amid these challenges, emergence nanotechnology extracellular vesicles (EVs) signals new dawn for treating diagnosing CNS ailments. EVs are cellularly derived lipid bilayer nanosized particles pivotal in intercellular communication within have potential to revolutionize targeted therapeutic delivery identification novel biomarkers. Integrating with amplifies diagnostic capabilities, opening avenues managing diseases. This review focuses on examining fascinating interplay between theranostics. Through highlighting remarkable advancements unique methodologies, we aim offer valuable perspectives how approaches can bring about revolutionary change management. The objective is harness distinctive attributes forge personalized, efficient interventions disorders, thereby providing beacon hope affected individuals. In short, confluence heralds promising frontier impactful treatments against diseases, which continue pose significant challenges. By focusing personalized powerful methods, might improve quality patients.
Language: Английский
Citations
5
Experimental Neurology, Journal Year: 2023, Volume and Issue: 368, P. 114506 - 114506
Published: Aug. 18, 2023
Language: Английский
Citations
12
Extracellular Vesicle, Journal Year: 2024, Volume and Issue: 3, P. 100044 - 100044
Published: May 13, 2024
Spinal cord injury (SCI) is the damage to spinal causing paralysis below site compromised patient life quality. Exosomes are nanosized vesicles released during physiological or pathological processes. They present a promising avenue for therapeutic drug delivery due their tissue specificity and biocompatibility, offering enhanced efficacy with reduced accumulation-based toxicity. In SCI, exosomes target inflammation, apoptosis, microglial polarization, autophagy, contributing interventions. This article comprehensively explores pathophysiology of diverse exosome synthesis processes, limitations challenges overcome, potential from various cellular sources in SCI treatment.
Language: Английский
Citations
4
Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 1281 - 1295
Published: March 1, 2025
The purpose of this study was to conduct a bibliometric analysis the literature on stem cell therapy for osteoarthritis (OA) visualize recent developments, identify hot spots, and determine trends in field. OA is chronic disease that affects joints their surrounding tissues, leading progressive damage articular cartilage ultimately subchondral bone synovial structures. disabling with an increasing incidence prevalence general population. Modulation immunity inflammation improvement survival differentiation through multidirectional cells potential strategy treatment OA. We searched publications "stem osteoarthritis" Web Science (WOS) core collection database from 1998-2024 summarized results, including year publication, country, institution, author, collaborative network generated using VOSviewer Citespace. In addition, research were identified. Finally, we topics identified future trends. This included 2341 valid papers, trend toward gradual increase number over time. journal highest citations China, University California system, Sekiya I, Osteoarthritis Cartilage, respectively. High-frequency keyword clusters therapy, cells, tissue engineering, extracellular vesicles. Through visualization analysis, elucidated hotspots field past five years. revealed transplantation exosome may be focus research. lays foundation clinical work
Language: Английский
Citations
0
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 769, P. 110434 - 110434
Published: April 22, 2025
Language: Английский
Citations
0
Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: Oct. 1, 2024
Language: Английский
Citations
3