Non-Coding RNA,
Journal Year:
2025,
Volume and Issue:
11(3), P. 30 - 30
Published: April 29, 2025
Adipocyte
differentiation
is
a
complex
process
in
which
pluripotent
mesenchymal
stem
cells
(MSCs)
differentiate
and
develop
into
mature
fat
cells,
also
known
as
adipocytes.
This
controlled
by
various
transcription
factors,
hormones,
signaling
molecules
that
regulate
the
development
of
these
cells.
Recently,
an
increasing
number
non-coding
RNAs
(ncRNAs),
especially
microRNAs
(miRNAs),
have
been
established
to
be
involved
regulation
many
biological
processes,
including
adipocyte
differentiation,
development,
metabolism,
energy
homeostasis
white
brown
adipose
tissue.
Several
vitro
vivo
studies
reported
significant
role
ncRNAs
either
promoting
or
inhibiting
targeting
specific
factors
regulating
expression
key
adipogenic
genes.
Identifying
function
their
subsequent
targets
contributes
our
understanding
how
can
used
potential
biomarkers
tools
for
therapies
against
obesity,
diabetes,
other
diseases
related
obesity.
could
contribute
advancements
tissue-engineering
based
treatments.
In
this
review,
we
intended
present
up-to-date
comprehensive
literature
overview
ncRNAs,
miRNAs,
long
(lncRNAs),
circular
(circRNAs),
focusing
particularly
on
addition,
further
discuss
use
novel
therapeutic
strategies
future
personalized
treatment
options
patients.
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(8), P. 365 - 365
Published: Aug. 12, 2024
Enhalus
acoroides,
a
tropical
seagrass,
is
known
for
its
significant
contribution
to
marine
ecosystems
and
potential
health
benefits
due
bioactive
compounds.
This
study
aims
compare
the
carotenoid
levels
in
E.
acoroides
using
green
extraction
via
ultrasound-assisted
(UAE)
microwave-assisted
(MAE)
evaluate
biological
properties
of
these
extracts
against
oxidative
stress,
diabetes,
obesity
through
silico
vitro
analyses.
samples
were
collected
from
Manado
City,
Indonesia,
subjected
UAE
MAE.
The
analyzed
UHPLC-ESI-MS/MS
identify
carotenoids,
including
β-carotene,
lutein,
lycopene,
β-cryptoxanthin,
zeaxanthin.
In
analysis
was
conducted
predict
compounds’
bioactivity,
toxicity,
drug-likeness
WAY2DRUG
PASS
molecular
docking
with
CB-Dock2.
compounds
C3,
C4,
C7
demonstrated
notable
interactions,
key
metabolic
proteins
microRNAs,
further
validating
their
therapeutic
benefits.
assays
evaluated
antioxidant
activities
DPPH
FRAP
assays,
antidiabetic
α-glucosidase
α-amylase
inhibition,
antiobesity
effects
lipase
inhibition
MTT
assay
3T3-L1
cells.
Results
indicated
that
both
MAE
exhibited
antioxidant,
antidiabetic,
activities.
showed
higher
content
greater
activity
compared
extracts.
These
findings
suggest
mainly
when
extracted
MAE,
has
promising
as
source
natural
developing
marine-based
agents.
supplements
existing
literature
by
providing
insights
into
efficient
methods
carotenoids.
Korean Circulation Journal,
Journal Year:
2025,
Volume and Issue:
55
Published: Jan. 1, 2025
Exosomes,
small
extracellular
vesicles
ranging
from
30
to
150
nanometers
in
diameter,
have
emerged
as
pivotal
mediators
of
intercellular
communication.
These
vesicles,
originally
perceived
cellular
debris,
are
now
recognized
for
their
intricate
roles
transporting
bioactive
molecules,
including
proteins,
lipids,
and
nucleic
acids,
between
cells.
Exosomes
received
considerable
attention
due
diverse
physiological
pathological
processes,
especially
relation
cardiovascular
diseases
(CVDs).
CVDs
intricately
linked,
sharing
common
risk
factors
mechanisms,
such
inflammation,
oxidative
stress,
endothelial
dysfunction.
been
implicated
either
directly
or
indirectly
influencing
these
phenomena.
They
secreted
by
virtually
all
cell
types,
cells,
cardiomyocytes,
stem
play
critical
maintaining
vascular
homeostasis
responding
stimuli.
Their
capacity
traverse
biological
barriers,
maintain
stability
circulation,
effectively
encapsulate
deliver
a
variety
molecular
cargos
makes
them
promising
candidates
both
biomarkers
therapeutic
agents.
This
review
aims
explore
the
multifaceted
exosomes
CVDs.
And
we
will
discuss
mechanisms
exosome
biogenesis
release,
composition,
ways
which
they
contribute
disease
pathophysiology.
Additionally,
emphasize
potential
diagnostic
uses,
highlighting
significance
advancement
innovative
treatment
strategies.
explores
recent
findings
advancements
research,
emphasizing
CVD
paving
way
future
studies
clinical
applications.
Non-Coding RNA,
Journal Year:
2025,
Volume and Issue:
11(3), P. 30 - 30
Published: April 29, 2025
Adipocyte
differentiation
is
a
complex
process
in
which
pluripotent
mesenchymal
stem
cells
(MSCs)
differentiate
and
develop
into
mature
fat
cells,
also
known
as
adipocytes.
This
controlled
by
various
transcription
factors,
hormones,
signaling
molecules
that
regulate
the
development
of
these
cells.
Recently,
an
increasing
number
non-coding
RNAs
(ncRNAs),
especially
microRNAs
(miRNAs),
have
been
established
to
be
involved
regulation
many
biological
processes,
including
adipocyte
differentiation,
development,
metabolism,
energy
homeostasis
white
brown
adipose
tissue.
Several
vitro
vivo
studies
reported
significant
role
ncRNAs
either
promoting
or
inhibiting
targeting
specific
factors
regulating
expression
key
adipogenic
genes.
Identifying
function
their
subsequent
targets
contributes
our
understanding
how
can
used
potential
biomarkers
tools
for
therapies
against
obesity,
diabetes,
other
diseases
related
obesity.
could
contribute
advancements
tissue-engineering
based
treatments.
In
this
review,
we
intended
present
up-to-date
comprehensive
literature
overview
ncRNAs,
miRNAs,
long
(lncRNAs),
circular
(circRNAs),
focusing
particularly
on
addition,
further
discuss
use
novel
therapeutic
strategies
future
personalized
treatment
options
patients.
