Revista Mexicana de Ingeniería Biomédica,
Journal Year:
2023,
Volume and Issue:
44(3), P. 37 - 54
Published: Sept. 1, 2023
Degenerative
tendinopathy
is
a
significant
health
problem,
and
its
incidence
increases
yearly.
This
condition
causes
functional
deficits
in
young
adult
patients
sedentary
or
active
individuals,
resulting
health,
social,
economic
consequences.
Due
to
limited
blood
supply,
drug
administration
complex
for
tendon
diseases,
such
as
degenerative
tendinopathy.
Biomaterials,
hydrogels,
have
gained
attention
designing
delivery
systems
treat
musculoskeletal
pathologies
due
their
attractive
characteristics
the
challenges
posed
by
conventional
routes.
paper
provides
an
overview
of
pathology
discusses
use
hydrogels
carriers
release
agents
emerging
treatments.
Carbon,
Journal Year:
2024,
Volume and Issue:
223, P. 118970 - 118970
Published: Feb. 26, 2024
Hydrogel-integrated
graphene
superstructures
(GSSs)
represent
a
promising
platform
for
applications
in
tissue
engineering
and
regenerative
medicine.
Graphene,
two-dimensional
carbon-based
material,
possesses
remarkable
mechanical,
thermal,
electrical
characteristics,
making
it
strong
candidate
application
biomedicine.
Researchers
have
pursued
the
integration
of
with
hydrogels,
known
their
biocompatibility
ability
to
provide
conducive
environment
cellular
growth,
craft
sophisticated
scaffolds
tailored
needs.
The
hydrogels
enables
construction
3D
frameworks
that
closely
mimic
natural
extracellular
matrix
(ECM)
found
biological
tissues.
Hydrogels
furnish
biocompatible,
well-hydrated
environment,
while
component
bolsters
scaffold's
mechanical
integrity
conductivity.
This
amalgamation
enhances
adhesion,
differentiation,
proliferation,
thereby
facilitating
regeneration.
A
notable
advantage
hydrogel-integrated
GSSs
lies
capacity
support
growth
differentiation
variety
cell
types
such
as
PC12,
MG-63,
U-87,
MC3T3-E1
lines.
Overall,
exhibit
great
potential
advancing
biomimetic
combination
unique
properties
development
advanced
scaffold
systems
Further
research
this
domain
will
play
crucial
role
medicine
treatment
various
diseases
injuries.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 29, 2024
Tendon
injuries,
a
common
musculoskeletal
issue,
usually
result
in
adhesions
to
the
surrounding
tissue,
that
will
impact
functional
recovery.
Macrophages,
particularly
through
their
M1
and
M2
polarizations,
play
pivotal
role
inflammatory
healing
phases
of
tendon
repair.
In
this
review,
we
explore
macrophage
polarization
healing,
focusing
on
insights
from
animal
models.
The
review
delves
into
complex
interplay
macrophages
pathology,
detailing
how
various
phenotypes
contribute
both
adhesion
formation.
It
also
explores
potential
modulating
activity
enhance
repair
minimize
adhesions.
With
advancements
understanding
behavior
development
innovative
biomaterials,
highlights
promising
therapeutic
strategies
for
injuries.
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(2), P. 614 - 641
Published: Jan. 4, 2024
Therapeutic
proteins
can
treat
a
myriad
of
diseases;
however,
their
effectiveness
is
limited
by
short
half-lives.
Controlled
release
systems
are
advantageous
because
they
prolong
the
action
protein
drugs,
minimize
transient
surges,
and
keep
concentrations
within
therapeutic
range.
Hydrogels
amenable
to
chemical
modifications
comprise
versatile
platform
for
controlled
release,
enabling
minimally
invasive
injections
at
injury
site
acting
as
depot
sustain
delivery
therefrom.
Affinity-based
strategies
have
binding
partners
immobilized
hydrogel
through
noncovalent
interactions
under
mild
conditions
that
maintain
three-dimensional
architecture
required
bioactivity.
Naturally
occurring
between
extracellular
matrix
components
were
advanced
first
but
inherently
limited.
Computational
experimental
tools
emerged
enable
high-specificity
moderate-affinity
candidate
proteins.
Directed
evolution
has
enabled
development
novel
peptide-,
protein-,
aptamer-binding
modulate
from
vehicles.
With
these
tools,
affinity-based
specific
tunable
rates
being
developed
diverse
applications,
including
tissue
regeneration
cancer
treatment.
These
now
be
tuned
multiple
bioactive
In
this
review,
we
examine
design
affinity-controlled
hydrogels
provide
insights
into
formulations
applications.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 12, 2025
Rotator
cuff
injury
(RCI),
characterized
by
shoulder
pain
and
restricted
mobility,
represents
a
subset
of
tendon-bone
insertion
injuries
(TBI).
In
the
majority
cases,
surgical
reconstruction
affected
tendons
or
ligaments
is
required
to
address
damage.
However,
numerous
clinical
failures
have
underscored
suboptimal
outcomes
associated
with
such
procedures.
Further
investigations
revealed
that
these
are
largely
attributable
delayed
healing
at
interface,
excessive
formation
vascularized
scar
tissue,
inadequate
integration
tendon
grafts
within
bone
tunnels.
As
result,
process
rotator
faces
significant
challenges.Bone
marrow-derived
mesenchymal
stem
cell
exosomes
(BMSC-exos)
emerged
as
prominent
focus
research
field
bioengineering,
owing
their
remarkable
potential
regulate
cellular
proliferation
differentiation,
modulate
immune
responses,
facilitate
tissue
repair
regeneration
following
this
review,
we
explore
anti-inflammatory,
angiogenic,
anti-scarring,
metabolism-modulating
effects
BMSC-exos
in
context
injury.
Additionally,
limitations
ongoing
challenges
current
research,
offering
insights
could
guide
application
treatment
future.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4039 - 4039
Published: April 24, 2025
Tendon
ruptures
are
common
musculoskeletal
injuries
associated
with
prolonged
healing
and
complications
such
as
adhesion
formation
rerupture.
Despite
advancements
in
treatment
strategies,
full
functional
recovery
remains
a
challenge.
Growth
factors
(GFs)
like
insulin-like
growth
factor-1
(IGF-1)
platelet-derived
factor-BB
(PDGF-BB)
play
key
roles
tendon
repair
may
have
synergistic
effects
when
applied
together.
To
support
healing,
bioactive
electrospun
polymer
scaffold
made
of
Degrapol®
(DP)
was
developed,
incorporating
IGF-1,
PDGF-BB,
or
both.
A
range
vitro
vivo
analyses
were
performed
to
assess
structure,
cell
behavior,
gene
expression,
metabolism,
biomechanical
outcomes
three
weeks
post-surgery.
Interestingly,
the
combined
application
IGF-1
PDGF-BB
did
not
simply
amplify
individual
but
showed
complex
interaction.
Depending
on
parameter
time
point,
combination
led
either
enhanced
reduced
responses
compared
single-factor
treatments,
indicating
modulation
rather
than
purely
additive
effect.
These
findings
suggest
that
can
modulate
cellular
molecular
processes
regeneration,
making
this
approach
promising
strategy
improve
healing.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(4), P. 251 - 251
Published: April 6, 2025
Tendons
connect
animal
skeletons
to
skeletal
muscles,
playing
a
crucial
role
in
weight-bearing
and
maintaining
motor
functions.
After
decellularization,
tendon
extracellular
matrix
(tECM)
retains
the
physicochemical
characteristics
similar
those
of
native
tendons.
This
has
made
tECM
promising
biomaterial
fields
tissue
engineering
regenerative
medicine
recent
years.
paper
summarizes
origin,
structure,
ECM
components
tendons,
reviews
decellularization
methods,
discusses
advancements
research
applications
decellularized
Furthermore,
it
explores
future
development
trends
xenogeneic
materials,
aiming
provide
reference
for
fundamental
biomaterials
related
Journal of Applied Biomaterials & Functional Materials,
Journal Year:
2025,
Volume and Issue:
23
Published: May 1, 2025
Tendon
injuries
present
a
significant
clinical
challenge
due
to
their
limited
natural
healing
capacity
and
the
mechanical
demands
placed
on
these
tissues.
This
review
provides
comprehensive
evaluation
of
current
strategies
advancements
in
tendon
repair
regeneration,
focusing
biomaterial
innovations
scaffold
design.
Through
systematic
literature
search
databases
such
as
PubMed,
Scopus,
Web
Science,
key
studies
were
analyzed
assess
efficacy
biocompatible
materials
like
hydrogels,
synthetic
polymers,
fiber-reinforced
scaffolds
promoting
healing.
Emphasis
is
role
collagen
fiber
architecture,
including
diameter,
alignment,
crimping,
restoring
strength
functional
properties
tendons.
Additionally,
highlights
emerging
techniques
electrospinning,
melt
electrowriting,
hybrid
textile
methods
that
allow
for
precise
designs
mimicking
native
structures.
Cutting-edge
approaches
regenerative
medicine,
stem
cell
therapies,
bioelectronic
devices,
bioactive
molecules,
are
also
explored
potential
enhance
repair.
The
findings
underscore
transformative
impact
technologies
improving
biomechanics
recovery.
Future
research
directions
outlined,
aiming
overcome
limitations
integration
at
tendon-bone
tendon-muscle
junctions.
contributes
development
more
effective
advancing
both
outcomes
field
orthopedic
tissue
engineering.
Tissue Engineering Part B Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 27, 2024
The
healing
process
after
tendon
injury
is
often
accompanied
by
the
formation
of
peritendinous
adhesion,
contributing
to
limb
dysfunction
and
exerting
detrimental
effects
on
individuals,
as
well
development
society
economy.
With
continuous
material
science,
augmented
understanding
mechanism
adhesion
formation,
materials
employed
for
fabrication
barrier
membranes
against
emerge
in
endlessly.
In
this
paper,
based
analysis
we
first
review
commonly
used
natural
synthetic
materials,
along
with
their
corresponding
strategies,
order
furnish
valuable
insights
future
optimization
anti-peritendinous
membranes.
This
paper
also
discusses
interaction
between
anti-adhesion
cells
ameliorating
adhesion.
