Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown
Published: June 11, 2024
Language: Английский
Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 123 - 123
Published: Jan. 7, 2024
Lung cancer demands innovative approaches for early detection and targeted treatment. In addressing this urgent need, exosomes play a pivotal role in revolutionizing both the treatment of lung cancer. Their remarkable capacity to encapsulate diverse range biomolecules, traverse biological barriers, be engineered with specific targeting molecules makes them highly promising diagnostic markers precise drug delivery cells. Furthermore, an in-depth analysis exosomal content biogenesis offers crucial insights into molecular profile tumors. This knowledge holds significant potential development therapies strategies Despite notable progress field, challenges standardization cargo loading persist. Collaborative research efforts are imperative maximize advance field precision medicine benefit patients.
Language: Английский
Citations
26
Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 61 - 61
Published: Jan. 7, 2025
In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such high biocompatibility, low toxicity, and modifiability, HA is becoming basis creation targeted systems, especially in field oncology. Receptors overexpressed subpopulations cancer cells, one them, CD44, recognized molecular marker stem cells. This review examines role receptors health tumors analyzes existing HA-based systems their use various types cancer. The new will bring opportunities challenges anti-cancer therapy.
Language: Английский
Citations
1
Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3804 - 3804
Published: July 26, 2023
Glioblastoma (GBM) is a highly aggressive and lethal primary brain cancer that necessitates early detection accurate diagnosis for effective treatment improved patient outcomes. Traditional diagnostic methods, such as imaging techniques tissue biopsies, have limitations in providing real-time information distinguishing treatment-related changes from tumor progression. Liquid used to analyze biomarkers body fluids, offer non-invasive dynamic approach detecting monitoring GBM. This article provides an overview of GBM including circulating cells (CTCs), cell-free DNA (cfDNA), RNA (cfRNA), microRNA (miRNA), extracellular vesicles. It explores the clinical utility these detection, monitoring, prognosis. Challenges implementing liquid biopsy strategies practice are also discussed. The highlights potential biopsies valuable tools personalized management but underscores need standardized protocols further research optimize their utility.
Language: Английский
Citations
19
Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 222, P. 116098 - 116098
Published: Feb. 29, 2024
Language: Английский
Citations
8
Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100825 - 100825
Published: Sept. 29, 2023
Thanks to its intrinsic properties, two-dimensional (2D) bismuth (bismuthene) can serve as a multimodal nanotherapeutic agent for lung cancer acting through multiple mechanisms, including photothermal therapy (PTT), magnetic field-induced hyperthermia (MH), immunogenic cell death (ICD), and ferroptosis. To investigate this possibility, we synthesized bismuthene from the exfoliation of 3D layered bismuth, prepared facile method that developed involving surfactant-assisted chemical reduction, with specific focus on improving properties. The nanosheets showed high in vitro vivo anti-cancer activity after simultaneous light field exposure adenocarcinoma cells. Only when are applied together, achieve highest compared single treatment groups. We have further shown ICD-dependent mechanisms were involved during combinatorial strategy. Beyond ICD, bismuthene-based PTT MH also resulted an increase ferroptosis both vivo, addition apoptotic pathways. Finally, hemolysis human whole blood wide variety assays peripheral mononuclear cells indicated biocompatible did not alter immune function. These results has potential platform arm therapeutic approaches against cancer.
Language: Английский
Citations
14
Advanced Therapeutics, Journal Year: 2023, Volume and Issue: 6(10)
Published: July 3, 2023
Abstract The rapid advancement of nanotechnology in recent years has opened new avenues investigation for biomedical sciences. Viral nanoparticles (VNPs) are formulated from plant viruses, mammalian or bacteriophages. Based on their structure, and synthetic carriers have been utilized to design bio‐inspired nanocarriers, which serve as building blocks innovative therapeutic applications. Scientists can chemically genetically engineer VNPs encompass various properties, such enhancing functionalization with molecules imaging reagents, enabling targeted delivery specific ligands. implementation these novel nanocarrier platforms revolutionize treatments cancer, infectious diseases, chronic illnesses. primary goal drug systems is localize cargo the target site, increasing benefits minimizing off‐target effects. This review critically evaluates major virus species used applications therapeutics, advantages disadvantages.
Language: Английский
Citations
12
Emergent Materials, Journal Year: 2024, Volume and Issue: unknown
Published: April 24, 2024
Language: Английский
Citations
4
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106186 - 106186
Published: Sept. 1, 2024
Language: Английский
Citations
4
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 255 - 255
Published: Feb. 14, 2025
Background/Objectives: Drug repurposing explores new applications for approved medications, such as simvastatin (SV), a lipid-lowering drug that has shown anticancer potential but is limited by solubility and side effects. This study aims to enhance SV delivery efficacy against lung cancer cells using bioactive lipid nanoparticles formulated with plant-derived monoterpenes both nanostructuring agents molecules. Methods: Lipid were produced ultrasonication characterized morphology, size, zeta potential, polydispersity index (PDI). Monoterpenes (linalool-LN-, limonene, 1,8-cineole) or Crodamol® used liquid lipids. Encapsulation efficiency (EE), release profiles, stability, biocompatibility, protein adsorption, cytotoxicity, effects evaluated. Results: The exhibited high size: 94.2 ± 0.9-144.0 2.6 nm, PDI < 0.3, potential: -4.5 0.7 -16.3 0.8 mV. of in all formulations enhanced cytotoxicity A549 cells, NLC/LN/SV showing the highest activity being chosen further investigation. Sustained over 72 h EE > 95% was observed NLC/LN/SV. SAXS/WAXS analysis revealed LN altered crystallographic structure nanoparticles. demonstrated excellent biocompatibility developed thin serum corona vitro. Cellular studies showed efficient uptake G0/G1 arrest, mitochondrial hyperpolarization, reactive oxygen species production, cell death compared free SV. more effectively inhibited migration than Conclusions: represents promising nanocarrier repurposing, combining activity, sustained stability therapy.
Language: Английский
Citations
0