Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 15, 2024
Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract
Language: Английский
Citations
26
Materials, Journal Year: 2024, Volume and Issue: 17(8), P. 1787 - 1787
Published: April 12, 2024
Nanomaterials (NMs) are having a huge impact in several domains, including the fabrication of medical devices (MDs). Hence, nanostructured MDs becoming quite common; nevertheless, associated risks must be carefully considered order to demonstrate safety prior their immission on market. The biological effect NMs requires consideration methodological issues since already established methods for, e.g., cytotoxicity can subject loss accuracy presence certain NMs. need for oversight containing is reflected by European Regulation 2017/745 MDs, which states that incorporating or consisting class III, at highest risk, unless NM encapsulated bound such manner potential its internal exposure low negligible (Rule 19). This study addresses role devices, highlighting current applications and considering regulatory requirements products.
Language: Английский
Citations
7
PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17807 - e17807
Published: Sept. 30, 2024
In recent years, advances in nanotechnology have significantly influenced electronics manufacturing, industrial processes, and medical research. Various industries seen a surge the use of nanomaterials. However, several researchers raised alarm about toxicological nature nanomaterials, which appear to be quite different from their crude forms. This altered can attributed unique physicochemical profile. They adversely affect human health environment. Nanomaterials that been released into environment tend accumulate over time cause significant impact on ecosystem organisms with adverse effects. Increased nanoparticles has led increased exposure daily lives, making them more vulnerable nanoparticle toxicity. Because small size, nanomaterials readily cross biological membranes enter cells, tissues, organs. Therefore, effect is particular concern. The effects mechanisms action are being researched worldwide. Technological also support monitoring new marketed for household purposes. It challenging area because exceptional properties updated review focuses diverse perspective We discussed types physiochemical responsible toxicity, routes exposure, bio-distribution, mechanism includes various
Language: Английский
Citations
7
Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)
Published: April 22, 2024
Abstract Patients with brain cancers including medulloblastoma lack treatments that are effective long‐term and without side effects. In this study, a multifunctional fluoropolymer‐engineered iron oxide nanoparticle gene‐therapeutic platform is presented to overcome these challenges. The fluoropolymers designed synthesized incorporate various properties robust anchoring moieties for efficient surface coating, cationic components facilitate short interference RNA (siRNA) binding, fluorinated tail ensure stability in serum. blood‐brain barrier (BBB) tailored system demonstrates enhanced BBB penetration, facilitates delivery of functionally active siRNA cells, delivers significant, almost complete block protein expression within an vitro extracellular acidic environment (pH 6.7) – as favored by most cancer cells. vivo, it effectively crosses intact BBB, provides contrast magnetic resonance imaging (MRI), capable slowing tumor growth causing signs toxicity meaning possesses safe theranostic function. pioneering methodology applied shows significant promise the advancement microenvironment‐focused MRI‐siRNA theranostics better treatment diagnosis medulloblastoma.
Language: Английский
Citations
6
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174674 - 174674
Published: July 11, 2024
Language: Английский
Citations
5
Nano Select, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
ABSTRACT Inhalation of biopersistent nanoplastics may have adverse effects on lung health. By varying the acetate content poly(vinyl acetate‐co‐alcohol) (PVAc), model with different surface hydrophobicity can be produced to study nanoplastic in lung. PVAc a high hydrophobicity, administered by oropharyngeal aspiration C57BL/6j mice (300 µg; ∼10 mg/kg), show transient pulmonary inflammation which peaks at 24 h post‐administration and resolves day 7. Hydrophilic induces no inflammatory same dose. Pulmonary administration hydrophilic hydrophobic increases prevalence (∼30%–35%) distinctive coarsely vacuolated alveolar macrophages over 28 days. Hydrophobic silica nanoparticles (control) induce minor collagen deposition, but do not stimulate tissue remodeling extent as bleomycin fibrosis. Longitudinal micro‐CT imaging is explored non‐invasive methodology for detection A bespoke image analysis method quantify density signal volume correlates moderately well histopathology‐derived deposition data ( R 2 = 0.73). In summary, inhaled following single 300 µg, an increase mild deposition.
Language: Английский
Citations
0
Cellular Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
Chimeric antigen receptor (CAR) therapy has successfully treated relapsed/refractory hematological cancers. This strategy can effectively target tumor cells. However, despite positive outcomes in clinical applications, challenges remain to overcome. These hurdles pertain the production of drugs, solid resistance, and side effects related treatment. Some cases have been missed during drug preparation due manufacturing issues, prolonged times, high costs. mainly arise from vitro process, so reevaluating this process could minimize number patients. The immune cells are traditionally collected sent laboratory; after several steps, modified express CAR gene before being injected back into patient's body. During vivo method, is introduced inside allows for treatment begin sooner, avoiding potential failures associated In review, we will elaborate on using CAR, examine benefits approach, ultimately present available solutions incorporating practice.
Language: Английский
Citations
0
Nanotoxicology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23
Published: Sept. 16, 2024
Silica nanoparticles are increasingly considered for drug delivery applications. These applications require an understanding of their biocompatibility, including interactions with the immune system. However, systematic studies silica nanoparticle immunological safety profiles lacking. To fill this gap, we conducted
Language: Английский
Citations
3
Research in Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(2), P. 148 - 156
Published: March 1, 2024
Background and purpose: Carbon nanotubes (CNTs) are a significant discovery in nanotechnology, with widespread applications modern technology. However, there concerns about their potential toxicity, particularly skin cells. This study aimed to investigate the mechanisms by which CNTs induced cytotoxicity apoptosis mouse fibroblasts. Experimental approach: The mice fibroblasts were isolated exposed two types of at various concentrations then analyzed for changes viability, reactive oxygen species (ROS) production, levels Bcl-2-associated X protein (Bax), lactate production. Findings/Results: results demonstrated that reduced cell viability increased ROS production dose-dependent manner. Additionally, current found Bax, pro-apoptotic protein, Furthermore, it was observed decrease cells CNTs. Conclusion implications: findings concluded have be toxic substances fibroblasts, serve as body's first line defense. is evidenced ability increase well reduce lactic acid levels. As has been reported beneficial effects on collagen further studies needed fully understand impact carbon nanotube exposure human health.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0