Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Macrophages are crucial drivers of innate immunity. Reprogramming macrophages to a restorative phenotype in cancer or autoimmune diseases can stop their cancer‐promoting activity trigger anti‐inflammatory Glycans have emerged as key components for immunity they involved many pathophysiological disorders. Previous studies demonstrated that supraphysiological amounts mannose (Man) sialic acid (Sia) inhibit tumor growth and stimulate differentiation regulatory T cells. Man is known affect glucose metabolism glycolysis by competing the same intracellular transporters affecting macrophage polarization, whereas Sia alters via signaling through Siglec‐1. Herein, this work describes targeting platform using gold nanoparticles (GNPs) functionalized with monosaccharides which exhibit high liver tropism. A single dose glyco‐GNPs convert two completely different immune environments. promotes tumor‐associated toward an antitumorigenic MC38 colorectal model secretion TNF‐α, IL ‐1β, ‐6 microenvironment. However, proinflammatory environment, observed mouse disease, primary biliary cholangitis, impairs production IL‐1β, Arg1, IL‐6 cytokines. The results probe dual role repolarization response system. This study proof‐of‐concept demonstrates nanomedicine specific glycans designed target other cells such myeloid cells, promising strategy not only against but also pathologies diseases.

Language: Английский

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Synergistic therapeutic strategies and engineered nanoparticles for anti-vascular endothelial growth factor therapy in cancer

Life Sciences, Journal Year: 2024, Volume and Issue: 341, P. 122499 - 122499

Published: Feb. 10, 2024

Language: Английский

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Extracellular Vesicles in Breast Cancer: From Intercellular Communication to Therapeutic Opportunities

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 654 - 654

Published: May 14, 2024

Breast cancer, a multifaceted and heterogeneous disease, poses significant challenges in terms of understanding its intricate resistance mechanisms devising effective therapeutic strategies. This review provides comprehensive overview the landscape extracellular vesicles (EVs) context breast highlighting their diverse subtypes, biogenesis, roles intercellular communication within tumour microenvironment (TME). The discussion spans various aspects, from EVs stromal cells cancer to influence on angiogenesis, immune response, chemoresistance. impact EV production different culture systems, including two dimensional (2D), three (3D), organoid models, is explored. Furthermore, this delves into potential presenting emerging strategies such as engineered for gene delivery, nanoplatforms targeted chemotherapy, disrupting derived treatment approach. Understanding these complex interactions milieu crucial identifying developing new targets.

Language: Английский

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CD248-expressing cancer-associated fibroblasts induce epithelial–mesenchymal transition of non-small cell lung cancer via inducing M2-polarized macrophages

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 21, 2024

Non-small cell lung cancer (NSCLC)-originating cancer-associated fibroblasts (CAFs) expressing CD248 regulate interaction with immune cells to accelerate progression. Epithelial-mesenchymal transition (EMT) is a key feature of metastatic cells. In our pervious study, we found that CD248+CAFs activated M2-polarized macrophages, enhancing the progression NSCLC. However, it yet unclear how inducing macrophages induce EMT program in NSCLC Herein, examined expression from CAFs derived patient tumour tissues. Furthermore, determined influence knock down on polarization. Next, explored influences CD248-harboring CAFs-mediated M2 macrophage polarization promote vitro. We constructed specific gene out mice examine significance CAFs-induced vivo. Based analysis, ubiquitously expressed within NSCLC-originating CAFs. mediated polarized type macrophages. induced enhance both vivo and Our findings indicate by regulating

Language: Английский

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Arginine and colorectal cancer: Exploring arginine-related therapeutic strategies and novel insights into cancer immunotherapies

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114146 - 114146

Published: Jan. 28, 2025

Language: Английский

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Macrophage-centered therapy strategies: a promising weapon in cancer immunotherapy

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101063 - 101063

Published: April 1, 2025

Language: Английский

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Harnessing miRNA Dynamics in HIV-1-Infected Macrophages: Unveiling New Targeted Therapeutics using Systems Biology

Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Role of the tumor microenvironment in cancer therapy: unveiling new targets to overcome drug resistance

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)

Published: May 7, 2025

Language: Английский

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A mini-review-cancer energy reprogramming on drug resistance and immune response

Translational Oncology, Journal Year: 2024, Volume and Issue: 49, P. 102099 - 102099

Published: Aug. 19, 2024

With the growing interest to harness cancer metabolism and energy reprogramming, this mini review aimed explain metabolic programming revealing mechanisms regarding treatment resistance. This summarized prominent reprogramming on macromolecules. In addition, explaining immune response resistance as well are briefly discussed. Finally, some prospects in MR for reversing drug highlighted.

Language: Английский

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Tumor-associated macrophages within the immunological milieu: an emerging focal point for therapeutic intervention

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e36839 - e36839

Published: Aug. 24, 2024

Tumor-associated macrophages play an important role in the tumor immune microenvironment, and regulating function of tumor-associated has therapeutic potential therapy. Mature could migrate to influencing multiple factors such as cell proliferation, invasion, metastasis, extracellular matrix remodeling, suppression, drug resistance. As a major component crosstalk with other cells. Currently, have garnered considerable attention therapy, broadening spectrum selection some extent, thereby aiding mitigating prevailing clinical resistance dilemma. This article summarizes recent advances concerning immunology, targeting mechanisms for treatment, new developments, existing challenges, offering insights future approaches. In addition, this paper summarized impact on current therapies, discussed advantages disadvantages targeted therapy compared predicted issues that need be focused on.

Language: Английский

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