Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Nov. 29, 2023
EDITORIAL article Front. Immunol., 29 November 2023Sec. Cancer Immunity and Immunotherapy Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1338119
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 29, 2024
Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignant tumor globally. Despite advancements in treatment methods, the overall survival rate remains low due to limitations such as poor targeting bioavailability, which result limited efficacy of traditional drug therapies. Nanomedicine considered be promising strategy therapy, offering potential for maximal anti-tumor effects. Nanocarriers can overcome biological barriers, enhance delivery efficiency targeted sites, minimize damage normal tissues. Currently, various nano-carriers have been developed construct new nanomedicine. This review aims provide an overview current status HNSCC necessity nanomedicine improving outcomes. Moreover, it delves into research progress treatment, with focus on enhancing radiation sensitivity, immunotherapy, effectively delivering chemotherapy drugs, utilizing small molecule inhibitors. Finally, this article discussed challenges prospects applying cancer treatment.
Language: Английский
Citations
3
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13615 - 13651
Published: Dec. 1, 2024
Macrophage is an important component in the tumor immune microenvironment, which exerts significant influence on development and metastasis. Due to their dual nature of promoting suppressing inflammation, macrophages can serve as both targets for immunotherapy tools treating malignancies. However, abundant infiltration tumor-associated dominated by immunosuppressive phenotype maintains a pro-tumor engineering using nanotechnology manipulate microenvironment represent feasible approach cancer immunotherapy. Additionally, considering phagocytic specifically tumor-targeting capabilities M1 macrophages, manipulated through cellular nanotechnology, well macrophage-derived exosomes macrophage membranes, also become effective treatment. In conclusion, nanotherapeutics targeting remains immense potential macrophage-mediated treatment methods will further enhance our understanding, diagnosis, various malignants.
Language: Английский
Citations
2
Journal of Nanoparticle Research, Journal Year: 2023, Volume and Issue: 25(12)
Published: Dec. 1, 2023
Language: Английский
Citations
1
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(5)
Published: Sept. 1, 2024
ABSTRACT Tumor‐associated macrophages (TAMs) constitute the largest number of immune cells in tumor microenvironment (TME). They play an essential role promoting progression and metastasis, which makes them a potential therapeutic target for cancer treatment. TAMs are usually divided into two categories: pro‐tumoral M2‐like antitumoral M1 phenotypes at either extreme. The reprogramming toward tumoricidal phenotype is particular interest restoration antitumor immunity immunotherapy. Notably, nanomedicines have shown great therapy due to their unique structures properties. This review will briefly describe biological features roles tumor, then discuss recent advances nanomedicine‐mediated repolarization Finally, perspectives on effective immunotherapy also presented.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 290, P. 138960 - 138960
Published: Dec. 20, 2024
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Nov. 29, 2023
EDITORIAL article Front. Immunol., 29 November 2023Sec. Cancer Immunity and Immunotherapy Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1338119
Language: Английский
Citations
0