Dynamics of an oblate spheroidal particle in a square duct filled with viscoelastic fluids DOI

Song Jiang,

Zhenyu Ouyang, Jianzhong Lin

et al.

Physics of Fluids, Journal Year: 2024, Volume and Issue: 36(11)

Published: Nov. 1, 2024

Herein, we used the fictitious domain method to numerically investigate lateral migration and rotation of an oblate spheroidal particle in a square duct filled with Oldroyd-B fluids. We adopted Reynolds numbers ranging from 25 100 Weissenberg 0.01 0.50. At low moderate (Wi ≤ 0.50), viscous forces remain dominant motion. Additionally, considered effects initial position, orientation, blocking ratio on dynamics. The results indicate that for flow channels finite fluid inertia, as Wi increases, elastic gradually strengthen, causing equilibrium position particles shift near centerline channel toward diagonal. Notably, under significant elasticity conditions, additional positions emerge corners channel. When released their x0–y0 plane (containing two longest axes spheroid) parallel x–y (duct cross section) field, exhibited three distinct motion modes: tumbling, rolling, kayaking. Tumbling was influenced by inertia corner attraction, which transitions rolling or study also emphasized orientation impacted sustained tumbling inertial flows. In addition, blockage (the equivalent diameter height) mainly affected positions, β 0.125 were readily attracted corners.

Language: Английский

Particle manipulation under X-force fields DOI
Chun‐Dong Xue,

Yifan Yin,

Xiaoyu Xu

et al.

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights recent technological advances for progress in particle manipulation under X-force fields, and forecasts the trajectory of future developments.

Language: Английский

Citations

1
Enhancing circulating tumor cells separation with integrated spiral and U-shaped cross-section microchannels using elasto-inertial microfluidics DOI

Moein Nouri,

Sina Ebrahimi, Alireza Bahramian

et al.

Sensors and Actuators A Physical, Journal Year: 2024, Volume and Issue: unknown, P. 116153 - 116153

Published: Dec. 1, 2024

Language: Английский

Citations

4
Square-based spiral microchannel for the separation of circulating tumor cells using surrogate optimization based on the inertial method DOI

Amirreza Khodayari,

Sina Ebrahimi,

Seyed Mohammad Hossein Rezaei Demneh

et al.

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(3)

Published: March 1, 2025

Detecting circulating tumor cells (CTCs) in cancer patients’ blood and distinguishing them from are crucial for early diagnosis controlling therapy effectiveness. Scientists have increasingly turned to microfluidic devices achieve this separation. Various methods exist separating CTCs cells, including the use of inertial forces, which is a well-established technique based on cell size. Although numerous computational experimental investigations been studied circle-base spiral microchannel, effect spiral's shape has not extensively explored during This study introduces square-based microchannel label-free rapid separation CTCs. In addition, geometric parameters [i.e., radius fillet (R), number fillets aspect ratio (AR)] practical (i.e., Reynolds sample sheath flow) investigated. Efficiency purity significant that demonstrate performance microchannel. The results showed at Re = 6 inlet 15 flow with eleven efficiency was 100%, over 90% Furthermore, surrogate optimization employed investigate different sizes (12–30 μm) optimize AR R. square cross section (AR 1) R 150 μm yielded high purity.

Language: Английский

Citations

0
Inertial focusing of spherical particles: The effects of rotational motion DOI
Dmitry Alexeev, Sergey Litvinov, Athena Economides

et al.

Physical Review Fluids, Journal Year: 2025, Volume and Issue: 10(5)

Published: May 14, 2025

Language: Английский

Citations

0
Investigation on sheathless inertial focusing within low-aspect ratio spiral microchannel for cascaded microfluidic tumor cell separation DOI
Tao Peng, Zhexin Zhang, Shuai Yuan

et al.

Physics of Fluids, Journal Year: 2024, Volume and Issue: 36(7)

Published: July 1, 2024

The high-precision and high-purity isolation of circulating tumor cells (CTCs) from whole blood is vital to early cancer detection. Cascaded microfluidic separation highly efficient because it connects multiple-stage separations in series. Here, we numerically investigated sheathless cell with size-dependent cascaded inertial deterministic lateral displacement (DLD) device. arranged the first-stage unit for particle focusing rough sorting, DLD second stage realizing further sorting purification. A parametric study flow rate range 100–600 μl/min aspect ratio 60:100 60:300 first was carried out optimize channel structure high-efficiency separation. Then, pre-separation mechanism within spiral microchannel analyzed. purity obtained CTCs efficiency were improved using a droplet-type microcolumn device as unit. cascade eliminates need additional force fields reduces complexity while simplifying operation reducing chance sample contamination.

Language: Английский

Citations

2
Microfluidic Device for Both Active and Passive Cell Separation Techniques: A Review DOI Creative Commons
Muhammad Asraf Mansor, Muhammad Asyraf Jamrus,

Chong Kar Lok

et al.

Sensors and Actuators Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100277 - 100277

Published: Dec. 1, 2024

Language: Английский

Citations

2
Dynamics of an oblate spheroidal particle in a square duct filled with viscoelastic fluids DOI

Song Jiang,

Zhenyu Ouyang, Jianzhong Lin

et al.

Physics of Fluids, Journal Year: 2024, Volume and Issue: 36(11)

Published: Nov. 1, 2024

Herein, we used the fictitious domain method to numerically investigate lateral migration and rotation of an oblate spheroidal particle in a square duct filled with Oldroyd-B fluids. We adopted Reynolds numbers ranging from 25 100 Weissenberg 0.01 0.50. At low moderate (Wi ≤ 0.50), viscous forces remain dominant motion. Additionally, considered effects initial position, orientation, blocking ratio on dynamics. The results indicate that for flow channels finite fluid inertia, as Wi increases, elastic gradually strengthen, causing equilibrium position particles shift near centerline channel toward diagonal. Notably, under significant elasticity conditions, additional positions emerge corners channel. When released their x0–y0 plane (containing two longest axes spheroid) parallel x–y (duct cross section) field, exhibited three distinct motion modes: tumbling, rolling, kayaking. Tumbling was influenced by inertia corner attraction, which transitions rolling or study also emphasized orientation impacted sustained tumbling inertial flows. In addition, blockage (the equivalent diameter height) mainly affected positions, β 0.125 were readily attracted corners.

Language: Английский

Citations

1