Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 3, 2024
Abstract
Since
the
diseases
that
cause
bone
defects
are
mostly
inflammatory
diseases,
current
grafts
unable
to
effectively
regulate
osteoimmune
activity,
leading
impaired
osteogenesis
and
unfavorable
regeneration.
In
this
study,
inspired
by
composition,
biomimetic
mesoporous
bioactive
glass
nanoparticle
(MBG)/bovine
serum
albumin
(BSA)
designed
for
defects.
Systematically,
MBG/BSA
evaluated
characterization,
bioactivity,
anti‐inflammatory,
antioxidant
osteogenic
activity.
proved
be
biocompatible
can
release
ions
including
calcium
silicon
in
a
sustained
manner.
Furthermore,
reprograms
macrophage
phenotype
toward
anti‐inflammation
is
beneficial
The
antioxidative
activity
also
validated
under
inflammation
mechanism
may
via
interleukin‐4
(IL‐4)/Signal
transducer
activator
of
transcription
6
(STAT6)
pathway.
differentiation
mineralization
facilitated
due
improved
immunoregulation
MBG/BSA.
Overall,
work
suggests
with
immunomodulatory
properties
an
ideal
material
regeneration
application.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 13, 2025
Resveratrol,
a
polyphenolic
compound
known
for
its
diverse
biological
activities,
has
demonstrated
multiple
pharmacological
effects,
including
anti-inflammatory,
anti-aging,
anti-diabetic,
anti-cancer,
and
cardiovascular
protective
properties.
Recent
studies
suggest
that
these
effects
are
partly
mediated
through
the
regulation
of
macrophage
polarization,
wherein
macrophages
differentiate
into
pro-inflammatory
M1
or
anti-inflammatory
M2
phenotypes.
Our
review
highlights
how
resveratrol
modulates
polarization
various
signaling
pathways
to
achieve
therapeutic
effects.
For
example,
can
activate
senescence-associated
secretory
phenotype
(SASP)
pathway
inhibit
signal
transducer
activator
transcription
(STAT3)
sphingosine-1-phosphate
(S1P)-YAP
axes,
promoting
suppressing
thereby
inhibiting
tumor
growth.
Conversely,
it
promote
suppress
by
NF-κB
activating
PI3K/Akt
AMP-activated
protein
kinase
(AMPK)
pathways,
thus
alleviating
inflammatory
responses.
Notably,
effect
on
is
concentration-dependent;
moderate
concentrations
tend
while
higher
may
favor
polarization.
This
concentration
dependence
offers
new
perspectives
clinical
treatment
but
also
underscores
necessity
precise
dosage
control
when
using
resveratrol.
In
summary,
exhibits
significant
potential
in
regulating
treating
related
diseases.
BMC Oral Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Aug. 23, 2024
The
presence
of
a
polymicrobial
dysbiotic
film
in
direct
and
constant
contact
with
periodontal
tissues
initiates
the
host
immune
response.
Interleukin
18
(IL-18)
triggers
up-regulates
production
other
proinflammatory
cytokines
(TNF-α,
IL-1β,
IL-6),
creating
vicious
cycle
that
expands
inflammatory
destructive
process
tissue.
A
systematic
review
meta-analysis
was
carried
out
main
propose
to
investigate
IL-18
expression
different
biological
samples
from
subjects
chronic
periodontitis.
protocol
followed
PRISMA
guidelines
registered
Open
Science
Framework
(OSF):
https://doi.org/10.17605/OSF.IO/BS9GM
.
digital
search
conducted
databases
PubMed,
ScienceDirect,
Google
Scholar,
Web
Dentistry
&
Oral
Sciences
Source
were
consulted
March
15th,
2005
February
10th,
2023.
Study
quality
assessed
using
JBI
tool
for
cross-sectional
studies
clinical
trials.
performed
random/fixed
effects
model
evaluate
concentration
serum,
plasma,
saliva,
gingival
tissue
GCF
exposure
group
compared
control
group.
strategy
provided
total
3,156
articles,
which
investigations
met
inclusion
criteria
15
articles
quantitatively
analyzed.
number
patients
studied
1,275
(682
cases
593
controls).
revealed
significantly
elevated
levels
saliva
periodontitis
healthy
(Serum:
SMD
=
62.73,
95%CI:
25.43-100.03,
Z
3.29,
p
0.001*;
Saliva:
243.63,
8.68-478.59,
2.03,
0.042*;
GCF:
150.26,
56.86-243.66,
3.15,
0.02*).
could
have
potential
be
used
as
complementary
diagnostic
tools
radiographic
parameters
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
AbstractBackground
Periodontitis
and
peri-implantitis
are
chronic
inflammatory
diseases
that
contribute
to
tissue
destruction
bone
loss.
Periodontitis
is
triggered
by
pathogenic
bacteria,
while
also
involves
metallic
particles,
which
increase
the
response.
Both
conditions
linked
activation
of
inflammasomes,
such
as
NLRP3
AIM2,
facilitate
release
pro-inflammatory
cytokines
like
IL-1β
IL-18
induce
pyroptosis.
This
study
aims
investigate
AIM2
inflammasomes
in
macrophages
exposed
bacterial
components,
well
explore
potential
interplay
between
these
two
signaling
pathways.
Methods
Human
THP-1-derived
were
treated
with
lipopolysaccharide
(LPS)
titanium
ions
evaluate
inflammasome
activation.
secretion,
ROS
production,
mitochondrial
DNA
pyroptosis
assessed.
Additionally,
deficient
used
examine
roles
responses.
Results
LPS
synergistically
activated
NLRP3,
resulting
increased
Under
conditions,
was
indirectly
activated,
indicated
elevated
release.
Notably,
expression
reduced
wild-type
LPS
compared
alone,
however,
NLRP3-deficient
cells,
following
treatment.
upregulation
cells
further
inhibition,
decreased
knockout
had
a
more
pronounced
effect
on
reducing
secretion
knockout,
indicating
greater
role
Conclusions
This
demonstrates
components
drive
both
macrophages,
highlighting
their
responses
associated
periodontitis
peri-implantitis.
The
findings
reveal
regulatory
relationship
where
absence
one
can
enhance
activity
other.
These
results
provide
new
insights
into
mechanisms
underlying
inflammasome-mediated
inflammation
suggest
therapeutic
targets
for
managing
diseases.
Journal Of Clinical Periodontology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
ABSTRACT
Aim
To
evaluate
the
impact
of
macrophage
depletion
on
bone
loss
and
inflammatory
responses
in
a
mouse
model
peri‐implantitis,
assessing
potential
as
therapeutic
strategy.
Materials
Methods
Using
6‐week‐old
male
C57BL/6
mice,
peri‐implantitis
was
induced
by
placing
silk
ligature
around
osteointegrated
dental
implants.
Mice
were
divided
into
three
groups:
Healthy
control
(Healthy
group);
with
liposomal
phosphate‐buffered
saline
(PBS
clodronate
for
(CLOD
group).
Two
weeks
after
placement,
micro‐CT,
histological
real‐time
PCR
analyses
performed
to
assess
density,
leukocyte
infiltration
cytokine
levels.
Results
The
CLOD
group
showed
significantly
higher
bone‐to‐implant
contact
(74%)
volume
relative
total
(79%)
compared
PBS
(53%
54%,
respectively)
(64%
66%,
respectively).
Histological
analysis
revealed
reduced
counts
group.
Additionally,
TNF‐α
IL‐10
levels
decreased
Conclusion
Macrophage
effectively
reduces
inflammation
peri‐implantitis.
This
study
highlights
targeting
macrophages
promising
approach
managing
although
further
research
is
needed
optimize
strategies.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 20, 2024
Impaired
wound
healing
is
one
of
the
main
clinical
complications
type
2
diabetes
(T2D)
and
a
major
cause
lower
limb
amputation.
Diabetic
wounds
exhibit
sustained
inflammatory
state,
reducing
inflammation
crucial
to
diabetic
management.
Macrophages
are
key
regulators
in
healing,
their
dysfunction
would
exacerbated
poor
wounds.
Gene
regulation
caused
by
histone
modifications
can
affect
macrophage
phenotype
function
during
healing.
Recent
studies
have
revealed
that
targeting
histone-modifying
enzymes
local,
macrophage-specific
manner
reduce
responses
improve
This
article
will
review
significance
as
well
illustrate
how
polarization
Targeting
with
may
provide
novel
therapeutic
strategies
for
treatment
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 1, 2024
Peri-implantitis,
a
complex
condition
that
can
lead
to
dental
implant
failure,
is
characterized
by
inflammatory
destruction
resulting
from
immune
dysregulation.
Oral
microbial
dysbiosis
and
foreign
body
stimulation
are
the
main
factors
contributing
such
dysregulation,
impairing
cell
function
triggering
an
response.
Immune
dysregulation
plays
critical
role
in
pathophysiology
of
peri-implantitis,
impacting
balance
T
subsets,
production
factors,
immune-related
molecular
signaling
pathways.
Understanding
relationship
between
peri-implantitis
crucial
for
developing
targeted
strategies
clinical
diagnosis
individualized
treatment
planning.
This
review
explores
similarities
differences
microenvironment
oral
bacterial
infections
rejection,
analyzes
relevant
pathways,
identifies
new
key
targets
innovative
immunotherapeutic
drugs
effective
personalized
modalities
peri-implantitis.
Additionally,
it
addresses
challenges
potential
directions
translating
immunotherapy
into
practice
offering
insights
bridge
gaps
current
literature
pave
way
future
research.
