Potential and challenges of utilizing exosomes in osteoarthritis therapy (Review)

International Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: 55(3)

Published: Jan. 8, 2025

Exosomes are integral to the pathophysiology of osteoarthritis (OA) due their roles in mediating intercellular communication and regulating inflammatory processes. transport bioactive molecules, such as proteins, lipids nucleic acids, which can influence chondrocyte behavior joint homeostasis. Given properties regeneration ability target damaged tissues, exosomes represent a promising therapeutic avenue for OA treatment. have potential promoting cartilage repair, reducing inflammation improving overall function. However, several challenges remain, including need standardized isolation characterization methods, variability exosomal content, regulatory hurdles. The present review aims provide comprehensive overview current understanding exosome mechanisms potential, while also addressing ongoing faced translating these findings into clinical practice. By consolidating existing research, pave way future studies aimed at optimizing exosome‑based therapies effective management.

Language: Английский

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The therapeutic potential of mesenchymal stromal cells and their secretome in sport-related injuries

Prospects in Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 23(1), P. 9 - 24

Published: Jan. 18, 2025

As the prevalence of sports-related injuries continues to rise, there is an urgent need for innovative therapeutic strategies that not only expedite recovery but also enhance quality healing. The application mesenchymal stromal cells (MSCs) therapy in treatment sports represents a groundbreaking advancement field regenerative medicine. This review aims summarize and discuss effects MSCs facilitating tissue regeneration expediting healing process following injuries. It highlight current research findings regarding efficacy, safety administration routes clinical trials. Data was obtained by searching Pubmed Google Scholar, using keywords: ‘sport injury, ‘Osteoarthritis’, ‘mesenchymal stromal/stem cells’, ‘tendon’, ‘cartilage defect’, ‘ligament injury’, ‘MSC secretome’, ‘conditioned medium’. According U. S. National Library Medicine, have been total 7,146 registered trials worldwide on stem cell till 5/10/2024, with 1,626 specifically focusing therapy. efficacy secretome therapies treating sport-related shown many preclinical studies. promising outcomes observed experimental studies propelled transition trials, which positive results. has potential accelerate processes, reduce downtime, allow athletes return their sport faster greater confidence. crucial professional recreational enthusiasts who seek maintain active lifestyle. However, bone marrow (BM-MSCs), umbilical cord (UCB-MSCs) adipose-derived (AD-MSCs) were predominantly utilized these indicating unexplored from other sources. contribute valuable knowledge field, aspires inspire further exploration innovation use enhancing athletic performance recovery.

Language: Английский

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Non-coding RNA-mediated granulosa cell dysfunction during ovarian aging: from mechanisms to potential interventions

Non-coding RNA Research, Journal Year: 2025, Volume and Issue: 12, P. 102 - 115

Published: March 4, 2025

As the earliest aging organ in reproductive system, ovary has both and endocrine functions, which are closely related to overall female health. The exact pathogenesis of ovarian (OA) remains incompletely understood, with granulosa cells (GCs) dysfunction playing a significant role this process. Recent advancements research biotechnology have highlighted importance non-coding RNAs (ncRNAs), including micro RNAs, long circular regulating biological functions GCs through gene expression modulation. This paper provides comprehensive overview ncRNAs various cellular such as apoptosis, autophagy, proliferation, steroid synthesis GCs, explores underlying regulatory mechanisms. Additionally, therapeutic potential ncRNAs, particularly those carried by exosomes derived from mesenchymal stem cells, delaying OA is discussed. Understanding mechanisms GC function current progress field crucial for identifying effective biomarkers targets, ultimately aiding early diagnosis, prognostic assessment, individualized treatment OA.

Language: Английский

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Glycoside components promote endothelial progenitor cell-derived exosomes repairing damaged vascular endothelium via the PI3K/AKT signaling pathway

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156694 - 156694

Published: March 1, 2025

Language: Английский

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The Use of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles in the Treatment of Osteoarthritis: Insights from Preclinical Studies

Bioengineering, Journal Year: 2024, Volume and Issue: 11(10), P. 961 - 961

Published: Sept. 26, 2024

Osteoarthritis (OA) is a prominent cause of disability, and has severe social economic ramifications across the globe. The main driver OA’s pervasiveness fact that no current medical interventions exist to reverse or even attenuate degeneration cartilage within articular joint. Crucial for cell-to-cell communication, extracellular vesicles (EVs) contribute OA progression through delivery bioactive molecules in inflammatory microenvironment. By repurposing this acellular means signal transmission, therapeutic drugs may be administered degenerated tissue hopes encouraging regeneration. Positive outcomes are apparent vivo studies on subject; however, therapy prove itself clinical world, efforts towards standardizing characterization, application, biological contents, dosage essential.

Language: Английский

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A Macroscopic Exploration of the Ideoscape on Exosomes for Bone Regeneration

Osteology, Journal Year: 2024, Volume and Issue: 4(4), P. 159 - 178

Published: Oct. 8, 2024

Background: Exosomes, nanoscale extracellular vesicles, play a crucial role in tissue physiology and regeneration. This study uses infometric techniques to explore the structure of exosome-based bone regeneration research. Methods: We applied BERTopic, an advanced topic modeling algorithm, comprehensive corpus scientific literature on exosomes regeneration, identifying key themes such as stem cell studies, healing, regenerative applications, with orthopedics dentistry emerging dominant subfields. To further investigate ‘ideoscape’, i.e., conceptual landscape that maps how ideas, methods, are interconnected across field, we extracted significant concepts from abstracts using GPT 3.5 turbo created knowledge graphs. Results: Our analysis revealed rapid growth field dental which has outpaced other topics by twofold. highlighted central periodontal cells their cellular processes—proliferation, migration, differentiation—along clinical applications. approach provided clear visualization field’s intellectual structure, showing interconnected. findings offer view evolving trends revealing not only most active research areas but also gaps opportunities for investigation. Conclusions: exemplifies utility combining graph creation map trends, offering flexible largely automated tool researchers vast bodies guide future directions.

Language: Английский

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Terapia celular na regeneração de tecidos musculoesqueléticos: Perspectivas na osteoartrite e uso de células-tronco mesenquimais

Research Society and Development, Journal Year: 2024, Volume and Issue: 13(4), P. e12213445652 - e12213445652

Published: April 30, 2024

A osteoartrite é uma condição musculoesquelética comum e debilitante que causa degeneração progressiva da cartilagem articular, resultando em dor, rigidez limitação mobilidade articular. Diante dos desafios do tratamento eficaz osteoartrite, a terapia celular emergiu como abordagem promissora para promover regeneração tecidos afetados. Este estudo apresenta revisão abrangente sobre na destacando os principais achados, perspectivas futuras dessa área. pesquisa foi realizada por meio seleção análise de estudos relevantes nas bases dados PubMed, Scopus Web of Science, com um período inclusão 20 anos. Foram priorizados primários, incluindo ensaios clínicos, meta-análises, clínicos randomizados revisões sistemáticas. Os resultados indicam celular, especialmente o uso células-tronco mesenquimais, oferece potencial cartilagem, reduzir inflamação modular resposta imune articulações afetadas pela osteoartrite. No entanto, são necessárias mais pesquisas otimizar as estratégias terapêuticas, superar técnicos regulatórios validar eficácia segurança longo prazo desses tratamentos.

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