Molecular mechanism of mechanical pressure induced changes in the microenvironment of intervertebral disc degeneration

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(12), P. 2153 - 2164

Published: Oct. 8, 2024

Language: Английский

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Enhancing Bone Health with Conjugated Linoleic Acid: Mechanisms, Challenges, and Innovative Strategies

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1395 - 1395

Published: April 21, 2025

Conjugated linoleic acid (CLA) is a bioactive compound known for its anti-inflammatory, anti-carcinogenic, and metabolic effects, with growing interest in role supporting bone health. Preclinical studies, particularly those involving the t10c12 isomer, have shown that CLA can enhance mineral density (BMD) by enhancing formation reducing resorption, indicating potential as therapeutic agent to improve However, clinical trials yielded inconsistent results, underscoring difficulty translating animal model successes human applications. A major challenge CLA’s low water solubility, poor absorption, limited bioavailability, which restrict effectiveness. To address these issues, nanoparticle-based delivery systems been proposed stability, resistance oxidative damage, thereby bioactivity. Recent studies also suggest electrical stimulation stimulate regeneration promoting cell proliferation, differentiation, adherence scaffolds. This review explores combined use of supplementation novel approach improving health, osteoporosis management. By integrating biological effects regenerative stimulation, this multimodal strategy offers promising method restoration, significant implications applications

Language: Английский

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Piezoelectric biomaterials with embedded ionic liquids for improved orthopedic interfaces through osseointegration and antibacterial dual characteristics

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 164, P. 213970 - 213970

Published: July 27, 2024

Orthopedic implant failures, primarily attributed to aseptic loosening and site infections, pose significant challenges patient recovery lead revision surgeries. Combining piezoelectric materials with ionic liquids as interfaces for orthopedic implants presents an innovative approach addressing both issues simultaneously. In this study, films of poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) incorporated 1-ethyl-3-methylimidazolium hydrogen sulfate ([Emim][HSO4]) liquid were developed. These exhibited strong antibacterial properties, effectively reducing biofilm formation, thereby implant-related infections. Furthermore, stem cell-based differentiation assays exposed the potential composite induce osteogenesis. Interestingly, our findings also revealed upregulation calcium channel expression a result electromechanical stimulation, pointing mechanistic basis observed biological effects. This work highlights improve longevity biocompatibility implants. Offering dual-functionality infection prevention bone integration, these advancements hold advancing technologies improving outcomes.

Language: Английский

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Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy

Hypertension Research, Journal Year: 2024, Volume and Issue: 47(10), P. 2786 - 2799

Published: Aug. 5, 2024

Language: Английский

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