Microwave‐Sintered Nano‐SiC Reinforced 8SiC/Ti‐3Cu Composite: Fabrication, Wear Resistance, Antibacterial Function, and Biocompatibility

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract The significance of biomedical applications Ti alloys is best emphasized by their widespread utilization as implantable materials, such internal supports and bone replacements. are sensitive to fretting wear, which leads the early failure implants. Improved wear resistance implants essential ensure a prolonged implant life. Based on structure‐function‐integrated concept, this work unprecedentedly designs fabricates an antibacterial 8SiC/Ti‐3Cu composite with improved using microwave sintering from pure Ti, Cu, nano‐SiC powders. For comparison, SiC‐free Ti‐3Cu manufactured under same conditions sintering. addition 8 vol.% SiC significantly reduces porosity pore size composites. shows Vickers hardness 353 HV, compressive strength 803 MPa, elastic modulus 28.7 GPa, increased (wear rate decreased 70% compared Ti‐3Cu). In addition, exhibits excellent electrochemical corrosion resistance, biocompatibility in relation MC3T3‐E1 cells, bacteriostatic over 99% against E. coli . combination wear‐resistant nano‐reinforced 2 Cu renders it highly promising material.

Language: Английский

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Advances in orthopedic implants: the role of nanotechnology in enhancing performance and longevity

Regenerative medicine reports ., Journal Year: 2025, Volume and Issue: 2(1), P. 15 - 21

Published: Feb. 6, 2025

Traditional orthopedic implants, despite being broadly accepted, come with numerous limitations such as low osseointegration, mechanical wear, and vulnerability to infection, thus causing complications consequent revision surgeries. Nanotechnology provides an innovative approach materials at the nanoscale, enhancing efficacy of implants used. This necessitates development that respond human movement, demonstrate greater durability, can be used for extended periods. Nanostructured surfaces coatings mimic conditions natural bone, promoting superior cell adhesion, proliferation, differentiation, which are essential both successful osseointegration bone regeneration. Moreover, use nanocoatings exhibit outstanding antibacterial properties, thereby reducing risk postoperative infections. Each component in a nanocomposite, ceramics, polymers, metals, contributes excellent performance stability effectively addressing issues related implant wearing failure. In addition, nanotechnology also facilitates incorportion drug delivery systems within allowing localized controlled release antibiotics or growth factors. targeted enhances healing minimizes side effects other parts body. Despite its capability transformation, challenges scalability manufacturing, potential toxicity, immunogenic responses, regulatory approval processes remain. review focuses on applications highlighting how these have impacted efficacy, strength, delivery. offers promising improving patient care better, complications, transforming future orthopedics. To fully realize potential, it is investigate current explore new areas research.

Language: Английский

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Critical review on biodegradable and biocompatibility magnesium alloys: Progress and prospects in bio-implant applications

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 169, P. 113111 - 113111

Published: Sept. 6, 2024

Language: Английский

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Nanostructured materials derived from high entropy alloys–State-of-the-art and leading technical applications

Results in Physics, Journal Year: 2024, Volume and Issue: 62, P. 107838 - 107838

Published: June 17, 2024

Exceptional category of alloys comprising five or more alloying metals in structures are referred as high entropy alloys. Uniqueness these have been observed due to the combination superior mechanical, thermal, conducting, anticorrosion, and other physical properties. Unlike traditional metallic (two metals), varying elemental compositions led limitless potential possibilities. Recent research has unveiled an important opportunity for based nanostructures like nanoparticles nanocomposites. This state-of-the-art review is basically intended highlight design essential structure, property, applied aspects alloy nanostructures. Consequently, various notable combinations with carbon (graphene, nanotube) inorganic surveyed. In this context, several nanocomposite designs reported using efficient techniques thermal shock, flame spray pyrolysis, plasma spark sintering, mechanical milling, alloying, electrochemical, solution name a few. The resulting derived nanomaterials researched microstructure, nanocrystalline different features (microhardness, modulus, stress–strain, compression properties), wear, range on pointed towards fields energy storage (batteries supercapacitors), radiation shielding, corrosion/wear coatings, biomedical uses.

Language: Английский

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Liquid crystalline coatings loaded with colistin for preventing development of biofilms on orthopedic implants

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

The current antibacterial strategies focus on antibiotic therapy and extensive hygienic measures during orthopedic surgery. However, potential development of implant-associated infections remains a persistent clinical challenge. There is, therefore, growing interest in introducing innovative safe for preventing combating biofilm implants. Antibacterial coatings, particularly, are attractive local delivery agents. We aim this proof-of-concept study at novel translatable implant coating approach, focusing directed assembly inverse non-lamellar lyotropic liquid crystalline (LLC) nanostructures implants prevention initial bacterial attachment formation through the widely used cationic colistin (COL). On exposure dry lipid films deposited model to aqueous solutions COL prepared different concentrations, set LLC coatings based commercial distilled monoglyceride product (or glycerol monooleate) were produced. In addition small-angle X-ray scattering (SAXS) characterization investigations, vitro studies conducted evaluating antibiofilm properties against Gram-negative bacteria Pseudomonas aeruginosa. SAXS analysis indicated that all samples bicontinuous cubic Pn3m phases. Significant COL's activity efficient protection adhesion demonstrated with surface produced by using containing concentrations 50 500 µg/mL. serum, detected structural alterations changes also discussed. This highlights implications self-assemblies designing nanostructural implants, which can prevent

Language: Английский

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Recent Advances and Challenges for Biological Materials in Micro/Nanocarrier Synthesis for Bone Infection and Tissue Engineering

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.

Language: Английский

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Saraca asoca extract mediated ZnO/PVA nanocomposite coatings for orthopaedic implants

Surface Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Orthopaedic implants commonly use titanium and its alloys because of their superior mechanical properties, corrosion resistance biocompatibility. However, these metal have limited application, hindered by poor osseointegration the potential risk implant-associated infections. To overcome obstacles, this study intends to address issues integrating haemocompatible antibacterial coatings made from green synthesised zinc oxide nanoparticles, using Saraca asoca leaf extract (SA-ZnO). These nanoparticles may serve improve osteoconductivity limit bacterial growth at site implant. The prepared (SA-ZnO) were characterized various techniques then integrated with polyvinyl alcohol (PVA), resulting in (SA-ZnO/PVA) nanocomposite. nanocomposites further coated onto Titanium alloy substrate (Ti-6Al-4V) doctor's blade technique morphologically characterized. Atomic force microscopy analysis demonstrated that SA-ZnO/PVA nanocomposite exhibited favourable micro-roughness, enhancing cell attachment promoting protein adsorption, which is crucial for effective osseointegration. Additionally, haemocompatibility tests no adverse effects on blood cells, indicating coating's compatibility biological systems. Antimicrobial studies showed a significant zone inhibition against both gram-negative gram-positive bacteria, highlighting coatings. Thus, findings imply ZnO amalgamated (PVA) as promising surface coating materials, can be used effectively orthopaedic reduce adherence growth, thus lowering incidence postoperative infections overall implant integration success.

Language: Английский

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A Review on Orthopaedic Biomaterials: Properties, Advances, and Future Directions

Journal of Condensed Matter, Journal Year: 2025, Volume and Issue: 3(02), P. 9 - 16

Published: May 4, 2025

Orthopaedic biomaterials play a pivotal role in advancing fracture fixation, joint replacement, and dynamic stabilization within orthopaedic applications. Primarily composed of metals, these exhibit outstanding properties including high strength, ductility, toughness, hardness, corrosion resistance, durability, biocompatibility. Despite their versatility, the landscape implant materials remains dominated by limited range ceramics, composites polymers. However, durability implants is challenged biological reactions material degradation caused wear electrochemical corrosion. This article examines developments that have taken place with respect to applications surgery. encompasses history, types polymers, composite biomaterials, processes fabricating them. The characteristics like biocompatibility, mechanical properties, fluid stability, ability induce osseointegration relevance such for surgery also discussed this article. Special attention given development novel bioactive metallic means improving resistance biocompatibility changing surface applying coats. scope review further covers advanced technologies smart bio-materials, 3D/4D printing, use nanotechnology, prosthetics. Further, discusses current status future trends concerning greater detail.

Language: Английский

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Synthetic Nanopillars for Stimulating Osteoblast Activity and Osteointegration in Bone-Related Disorders

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2205 - 2223

Published: Feb. 1, 2025

Osteoporosis, osteoarthritis, and fractures are bone-related disorders that have a huge impact on the quality of life healthcare systems worldwide. Traditional treatments, including bone grafts, their limitations, with grafts often being rejected by immune system infected, making new treatments necessary. Nanopillars based synthetic polymers been demonstrated to be promising tools for regeneration repair, showing emulate extracellular matrix composition, stimulate osteoblast activity induce osteointegration. In this review, nanopillars fabrication techniques, such as electrospinning, nanoimprint lithography self-assembly, also state art technology presented. Their role in modulating cellular responses via both physical biochemical means, enhance mineralization stabilize implants is discussed. Additionally, applications treating disorders, eg promotion fracture healing, augmentation dental or orthopedic implants, improvement tissue engineering discussed review. Using these focuses, each section examines opportunities challenges (eg optimizing processes, improving biocompatibility, investigating integration upcoming therapies like gene stem cell therapy) potential nanopillar technology. Finally, review points out requirement scalable long term biocompatibility studies multifunctional therapeutic strategies fully employ clinical scenarios. This seeks consolidate current knowledge polymer identify future directions use related through comprehensive

Language: Английский

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АНАЛИЗ ИССЛЕДОВАНИЯ ТЕХНОЛОГИИ БЕСПРОВОДНОГО ДАТЧИКА ДЛЯ МОНИТОРИНГА ТЕМПЕРАТУРЫ В ЗОНАХ УСТАНОВКИ ОРТОПЕДИЧЕСКИХ ИМПЛАНТАТОВ

Вестник Академии гражданской авиации, Journal Year: 2025, Volume and Issue: 36(1)

Published: March 1, 2025

Цель данного исследования заключается в разработке и апробации инновационной методической концепции мониторинга работы ортопедических имплантатов с использованием современных технологий беспроводных датчиков алгоритмов искусственного интеллекта. В работе проведён подробный анализ существующих методов диагностики состояния имплантатов, выявлены их технические методологические ограничения, а также проанализированы современные тенденции области медицины, направленные на повышение надежности безопасности имплантации. Предлагаемая методика объединяет сбор температурных других физических данных помощью высокоточных сенсоров обработку применением машинного обучения для предсказания возможных отклонений своевременного обнаружения начальных признаков износа или повреждения. Экспериментальная часть включает тестирование разработанной системы реальных клинических условиях, что позволило получить значимые статистические доказательства её эффективности точности. Результаты показали, применение инновационного подхода позволяет не только повысить точность диагностики, но значительно сократить время реагирования потенциальные осложнения, имеет важное значение оперативного вмешательства снижения риска неблагоприятных исходов. Представленный подход открывает новые перспективы дальнейших исследований медицинских способствуя развитию персонализированной медицины улучшению качества жизни пациентов.

Language: Русский

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