International Journal of Scientific Research in Science and Technology,
Journal Year:
2024,
Volume and Issue:
11(6), P. 826 - 840
Published: Dec. 27, 2024
The
integration
of
silver
nanoparticles
(AgNPs)
into
bone
cement
has
emerged
as
a
cutting-edge
approach
to
enhance
the
functional
properties
orthopedic
biomaterials.
Silver
nanoparticles,
known
for
their
broad-spectrum
antimicrobial
properties,
provide
an
innovative
solution
combat
implant-associated
infections.
This
review
delves
synthesis
methods,
including
in
situ
formation
and
physical
blending,
examines
performance
AgNP-infused
terms
efficacy,
mechanical
strength,
biocompatibility.
By
addressing
challenges
such
cytotoxicity
regulatory
considerations,
this
analysis
highlights
its
transformative
potential
reducing
infection
rates,
enhancing
implant
longevity,
ultimately
improving
patient
outcomes
surgeries.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 11, 2025
Bone
marrow
is
vital
for
hematopoiesis,
producing
blood
cells
essential
oxygen
transport,
immune
defense,
and
clotting.
However,
disorders
like
leukemia,
lymphoma,
aplastic
anemia,
myelodysplastic
syndromes
can
severely
disrupt
its
function,
leading
to
life-threatening
complications.
Traditional
treatments,
including
chemotherapy
stem
cell
transplants,
have
significantly
improved
patient
outcomes
but
are
often
associated
with
severe
side
effects
limitations,
necessitating
the
exploration
of
safer,
more
targeted
therapeutic
strategies.
Nanotechnology
has
emerged
as
a
promising
approach
addressing
these
challenges,
particularly
in
delivery
nutraceuticals—bioactive
compounds
derived
from
food
sources
potential
benefits.
Despite
their
promise,
nutraceuticals
face
clinical
limitations
due
poor
bioavailability,
instability,
inefficient
target
sites.
Nanoparticles
offer
viable
solution
by
enhancing
stability,
absorption,
transport
bone
while
minimizing
systemic
effects.
This
study
explores
range
disorders,
conventional
treatment
modalities,
nanoparticles
enhance
nutraceutical-based
therapies.
By
improving
efficacy,
could
revolutionize
disease
management,
providing
patients
effective
less
invasive
options.
These
advancements
represent
significant
step
toward
safer
efficient
approaches,
ultimately
prognosis
overall
health.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(18), P. 1484 - 1484
Published: Sept. 12, 2024
Percutaneous
implants
osseointegrated
into
the
residuum
of
a
person
with
limb
amputation
need
to
provide
mechanical
stability
and
protection
against
infections.
Although
significant
progress
has
been
made
in
biointegration
percutaneous
implants,
problem
forming
reliable
natural
barrier
at
level
surface
implant
skin
bone
tissues
remains
unresolved.
The
use
microporous
structure
incorporated
Skin
Bone
Integrated
Pylon
(SBIP)
should
address
issue
by
allowing
soft
grow
directly
itself,
which,
turn,
form
infections
support
strong
osseointegration.
To
evaluate
biological
interactions
between
dermal
fibroblasts
MC3T3-E1
osteoblasts
vitro,
small
titanium
discs
(with
varying
pore
sizes
volume
fractions
achieve
deep
porosity)
were
fabricated
via
3D
printing
sintering.
cell
viability
MTT
assay
demonstrated
low
cytotoxicity
for
cells
co-cultured
pores
3D-printed
sintered
Ti
samples
during
14-day
follow-up
period.
A
subsequent
Quantitative
Real-Time
Polymerase
Chain
Reaction
(RT-PCR)
analysis
relative
gene
expression
biomarkers
that
are
associated
adhesion
(α2,
α5,
αV,
β1
integrins)
extracellular
matrix
components
(fibronectin,
vitronectin,
type
I
collagen)
micropore
ranging
from
200
500
µm
printed
favorable
fibroblast
adhesion.
For
example,
representative
sample
S6
72
h
values
4.71
±
0.08
(α2
integrin),
4.96
(α5
(αV
1.87
0.12
(β1
integrin).
In
contrast,
400
800
best
results
(in
terms
marker
related
osteogenic
differentiation,
including
osteopontin,
osteonectin,
osteocalcin,
TGF-β1,
SMAD4)
cells.
S4
on
day
14,
levels
11.19
0.77
(osteopontin),
7.15
0.29
(osteonectin),
6.08
(osteocalcin),
while
markers
constituted
5.85
0.4
4.45
0.36
4.46
0.3
(osteocalcin).
conclusion,
data
obtained
show
high
biointegrative
properties
porous
structures,
ability
implement
several
options
one
using
makes
it
possible
create
personalized
one-time
integration
both
tissues.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: May 27, 2024
A
developing
use
of
nanotechnology
in
medicine
involves
using
nanoparticles
to
administer
drugs,
genes,
biologicals,
or
other
materials
targeted
cell
types,
such
as
cancer
cells.
In
healthcare,
has
brought
about
revolutionary
changes
the
treatment
various
medical
and
surgical
conditions,
including
orthopedic.
Its
clinical
applications
surgery
range
from
instruments
suture
enhancing
imaging
techniques,
drug
delivery,
visualization
methods,
wound
healing
procedures.
Notably,
plays
a
significant
role
preventing,
diagnosing,
treating
orthopedic
disorders,
which
is
crucial
for
patients’
functional
rehabilitation.
The
integration
improves
standards
patient
care,
fuels
research
endeavors,
facilitates
trials,
eventually
patient’s
quality
life.
Looking
ahead,
holds
promise
achieving
sustained
success
numerous
disciplines,
surgery,
years
come.
This
review
aims
focus
on
application
highlighting
recent
development
future
perspective
bridge
translation.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 23, 2024
Biopolymers
such
as
chitosan
and
pectin
are
currently
attracting
significant
attention
because
of
their
unique
properties,
which
valuable
in
the
food
industry
pharmaceutical
applications.
These
properties
include
non-toxicity,
compatibility
with
biological
systems,
natural
decomposition
ability,
structural
adaptability.
The
objective
this
study
was
to
assess
performance
two
different
ratios
pectin-chitosan
polyelectrolyte
composite
(PCPC)
after
applying
them
a
coating
commercially
pure
titanium
(CpTi)
substrates
using
electrospraying.
PCPC
studied
1:2
1:3,
while
control
group
consisted
CpTi
without
any
coating.
pull-off
adhesion
strength,
cytotoxicity,
antibacterial
susceptibility
tests
were
utilized
evaluate
coatings.
In
order
determine
whether
result
physical
blending
or
chemical
bonding,
topographic
surface
parameters
Fourier
transform
infrared
spectroscopy
(FTIR)
atomic
force
microscopy
(AFM).
(1:3)
had
highest
average
cell
viability
93.42,
89.88,
86.85%
24,
48,
72
h,
respectively,
determined
by
cytotoxicity
assay,
when
compared
other
groups.
According
Kirby-Bauer
disk
diffusion
method
for
testing
susceptibility,
showed
diameter
zone
inhibition,
measuring
14.88,
14.43,
11.03
mm
h
incubation,
respectively.
This
difference
highly
Group
3
at
all
three
time
periods.
exhibited
significantly
higher
mean
strength
(521.6
psi)
(1:2),
revealed
419.5
psi.
coated
better
roughness
groups
based
on
findings
AFM.
FTIR
measurement
indicated
that
both
purely
Based
extent
these
successful
vitro
experiments,
demonstrates
its
potential
an
effective
layer.
Therefore,
pave
way
newly
developed
electrospraying
dental
implants.
Journal of Nanotheranostics,
Journal Year:
2024,
Volume and Issue:
5(4), P. 167 - 187
Published: Nov. 13, 2024
Nanomaterials
hold
significant
promise
for
the
future
of
orthopaedic
implants
due
to
their
ability
mimic
nanoscale
components
bone,
such
as
collagen
fibrils
and
hydroxyapatite.
can
regulate
cell
behaviour
while
offering
mechanical
strength
biocompatibility,
making
them
ideal
bone
repair
tissue
regeneration.
This
comprehensive
review
explores
key
existing
potential
applications
nanotechnology
in
orthopaedics,
including
engineering,
drug
delivery
systems,
systems
combatting
implant-related
infections,
surface
preparation
enhance
osseointegration.
These
innovations
are
poised
revolutionise
care
by
improving
implant
durability,
reducing
infection
risks,
promoting
regeneration
deliver
personalised
treatment
create
better
patient
outcomes.
International Journal of Scientific Research in Science and Technology,
Journal Year:
2024,
Volume and Issue:
11(6), P. 826 - 840
Published: Dec. 27, 2024
The
integration
of
silver
nanoparticles
(AgNPs)
into
bone
cement
has
emerged
as
a
cutting-edge
approach
to
enhance
the
functional
properties
orthopedic
biomaterials.
Silver
nanoparticles,
known
for
their
broad-spectrum
antimicrobial
properties,
provide
an
innovative
solution
combat
implant-associated
infections.
This
review
delves
synthesis
methods,
including
in
situ
formation
and
physical
blending,
examines
performance
AgNP-infused
terms
efficacy,
mechanical
strength,
biocompatibility.
By
addressing
challenges
such
cytotoxicity
regulatory
considerations,
this
analysis
highlights
its
transformative
potential
reducing
infection
rates,
enhancing
implant
longevity,
ultimately
improving
patient
outcomes
surgeries.
