Research Progress of Bone Grafting: A Comprehensive Review DOI Creative Commons
Jing Zhang,

Wanhao Zhang,

Wenjie Yue

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 4729 - 4757

Published: April 1, 2025

Bone tissue, the second most transplanted tissue after blood, is utilized in over 2.2 million bone grafts annually to address various bone-related conditions including fractures, tumors, infections, scoliosis, congenital defects, osteoporosis, osteoarthritis, and osteogenesis imperfecta. According incomplete statistics, $4.3 billion was spent on graft materials 2015 alone, with projections suggesting this figure may reach $66 by 2026. The limited availability of autogenous considered gold standard due their three critical biological properties: osteoconduction, osteoinduction, osteogenesis-alongside increasing global aging population, be contributing rising expenditure. Furthermore, advancements biomaterials engineering technologies have created opportunities for exploration new substitutes. In review, we will examine fundamental structure natural characteristics ideal graft, highlighting common currently available, such as true ceramics, decalcified matrix, freeze-dried demineralized bone, bioactive glasses, marrow aspirate concentrate, polymer nanocomposites, which different osteogenic, osteoconductivity, osteoinductivity, biocompatibility, mechanical properties, resorption. How utilize its advantages maximize osteogenic effect focus some current challenges field grafting identified, outlining potential directions future development. conclusion, choice repair regeneration, a comprehensive understanding disadvantages can improve effectiveness related surgical interventions.

Language: Английский

Research Progress of Bone Grafting: A Comprehensive Review DOI Creative Commons
Jing Zhang,

Wanhao Zhang,

Wenjie Yue

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 4729 - 4757

Published: April 1, 2025

Bone tissue, the second most transplanted tissue after blood, is utilized in over 2.2 million bone grafts annually to address various bone-related conditions including fractures, tumors, infections, scoliosis, congenital defects, osteoporosis, osteoarthritis, and osteogenesis imperfecta. According incomplete statistics, $4.3 billion was spent on graft materials 2015 alone, with projections suggesting this figure may reach $66 by 2026. The limited availability of autogenous considered gold standard due their three critical biological properties: osteoconduction, osteoinduction, osteogenesis-alongside increasing global aging population, be contributing rising expenditure. Furthermore, advancements biomaterials engineering technologies have created opportunities for exploration new substitutes. In review, we will examine fundamental structure natural characteristics ideal graft, highlighting common currently available, such as true ceramics, decalcified matrix, freeze-dried demineralized bone, bioactive glasses, marrow aspirate concentrate, polymer nanocomposites, which different osteogenic, osteoconductivity, osteoinductivity, biocompatibility, mechanical properties, resorption. How utilize its advantages maximize osteogenic effect focus some current challenges field grafting identified, outlining potential directions future development. conclusion, choice repair regeneration, a comprehensive understanding disadvantages can improve effectiveness related surgical interventions.

Language: Английский

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