Evaluation of Anti-Inflammatory and Antibacterial Properties of Photo-Thermal Hydrogel as Dual Functional Platform for Management of Periodontitis DOI Creative Commons

Zhihong Mai,

Y.S. Mai,

Xianxian Huang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2923 - 2934

Published: March 1, 2025

Background: Periodontitis, one of the most common oral diseases caused by bacterial infection which affects gums, periodontal ligament and alveolar bone, is a leading cause tooth loss in adults. Current clinical treatments, such as scaling or antibiotics, often result incomplete biofilm removal can contribute to drug resistance. Methods: To address these limitations, nanozyme comprising platinum, copper, selenium was developed, then incorporated into thermoresponsive hydrogel. Results: When applied pockets exposed 808 nm laser irradiation, hydrogel became soft, dissolving release nanozyme. This demonstrated superoxide dismutase (SOD)-like catalase (CAT)-like activity, reducing excess reactive oxygen species (ROS) while displaying strong antibacterial anti-inflammatory effects. Conclusion: photothermal showed excellent biocompatibility has potential overcome challenges current periodontitis treatments. Keywords: thermosensitive, therapy, hydrogel,

Language: Английский

Bioactive Functionalized Chitosan Thermo‐Responsive Hydrogels as Promising Platforms for Therapeutic, Regenerative Oral, and Maxillofacial Applications DOI

Meshari Alkandari,

Paritosh Barai,

Gamal Abdel Nasser Atia

et al.

Biotechnology Journal, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

ABSTRACT Due to their superior physicochemical features, chitosan thermosensitive hydrogels are multipurpose platforms that frequently used in the biomedical industry. Many investigations have been conducted recently modify pore dimensions, expansion, biodegradability, stimulus‐reaction characteristics, and other characteristics order better tailor them complex craniofacial tissues. They focus of various studies attempted load biological cargos for therapeutic regenerative uses oro‐facial This article assesses utility advancements hydrogel‐based pharmaceutical delivery devices management disorders such as dental caries, endodontic diseases, periodontitis, temporomandibular disorders, mucosal cancer, so forth.

Language: Английский

Citations

0
Evaluation of Anti-Inflammatory and Antibacterial Properties of Photo-Thermal Hydrogel as Dual Functional Platform for Management of Periodontitis DOI Creative Commons

Zhihong Mai,

Y.S. Mai,

Xianxian Huang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2923 - 2934

Published: March 1, 2025

Background: Periodontitis, one of the most common oral diseases caused by bacterial infection which affects gums, periodontal ligament and alveolar bone, is a leading cause tooth loss in adults. Current clinical treatments, such as scaling or antibiotics, often result incomplete biofilm removal can contribute to drug resistance. Methods: To address these limitations, nanozyme comprising platinum, copper, selenium was developed, then incorporated into thermoresponsive hydrogel. Results: When applied pockets exposed 808 nm laser irradiation, hydrogel became soft, dissolving release nanozyme. This demonstrated superoxide dismutase (SOD)-like catalase (CAT)-like activity, reducing excess reactive oxygen species (ROS) while displaying strong antibacterial anti-inflammatory effects. Conclusion: photothermal showed excellent biocompatibility has potential overcome challenges current periodontitis treatments. Keywords: thermosensitive, therapy, hydrogel,

Language: Английский

Citations

0