Hybrid Hydrogel Supplemented with Algal Polysaccharide for Potential Use in Biomedical Applications DOI Creative Commons
Dana Stan, Andreea-Cristina Mirica, Sorin Mocanu

et al.

Gels, Journal Year: 2024, Volume and Issue: 11(1), P. 17 - 17

Published: Dec. 30, 2024

Hydrogels are a viable option for biomedical applications due to their biocompatibility, biodegradability, and ability incorporate various healing agents while maintaining biological efficacy. This study focused on the preparation characterization of novel hybrid hydrogels enriched with natural algae compound Ulvan potential use in wound dressings. The hydrogel membranes involved multiple methods assess structural, mechanical, chemical properties, such as pH measurements, swelling, moisture content uptake, gel fraction, hydrolytic degradation, protein adsorption denaturation tests, rheological SEM, biocompatibility testing, scratch assay. obtained higher concentration (1 mg/mL) exhibited superior mechanical swelling index 264%, water 55%, lower degradation percentage. In terms inclusion ULV composition enhanced strength, Alginate + PVA 1.0ULV sample demonstrated greatest resistance deformation. All good cell viability above 70% no obvious morphological modifications. addition potentiates regenerative effect membranes. Subsequent studies will focus encapsulating bioactive compounds, investigating release behavior, evaluating active effects.

Language: Английский

Toward Natural Wound Healing Therapy: Honey and Calendula officinalis Loaded κ-Carrageenan Films with Promising Hemostatic Potential DOI Creative Commons
Jovana S. Vuković, Srdjan Perišić, Anja Nikolić

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 578 - 578

Published: April 28, 2025

Background/Objectives: Efficient wound treatment embraces the management of four overlapping phases, starting with hemostasis, an immediate physiological response aimed at stopping bleeding from damaged blood vessels caused by skin injury. This paper proposes innovative, nature-based hemostatic biomaterial designed to assist natural self-healing regenerative mechanisms. Methods: Light, transparent, and skin-adhesive films based on κ-carrageenan, meadow polyfloral honey, Calendula officinalis flower extract were fabricated via solution casting. Comprehensive characterization revealed physicochemical, structural, swelling, barrier properties influence each bioactive compound utilized for film preparation. Results: The samples subcutaneously implanted in Wistar rats induced vascularization, deposition collagen, orientation collagen fibers while being fully phagocytosed gradually biodegraded. rat tail-cut model demonstrated that significantly reduced loss (0.1875 ± 0.0732 g) compared control (0.7837 0.3319 g), hemostasis was achieved notably faster (355.75 71.42 s) than group (704.25 85.29 s). liver punch biopsy confirmed (2.8025 1.5174 shorter time (303.25 77.90 (3.1475 1.5413 g, 383.00 36.53 Conclusions: results indicate great potential as dressings.

Language: Английский

Citations

0
Carboxymethyl Cellulose/Polyvinyl Alcohol/Covalent Organic Framework Composite Hydrogel Beads for the Removal of Heavy Metal Ions from Aqueous Solutions DOI

Hongxia Sun,

Yujie Zhang, Zhenhua Wu

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112648 - 112648

Published: April 1, 2025

Language: Английский

Citations

0
Hybrid Hydrogel Supplemented with Algal Polysaccharide for Potential Use in Biomedical Applications DOI Creative Commons
Dana Stan, Andreea-Cristina Mirica, Sorin Mocanu

et al.

Gels, Journal Year: 2024, Volume and Issue: 11(1), P. 17 - 17

Published: Dec. 30, 2024

Hydrogels are a viable option for biomedical applications due to their biocompatibility, biodegradability, and ability incorporate various healing agents while maintaining biological efficacy. This study focused on the preparation characterization of novel hybrid hydrogels enriched with natural algae compound Ulvan potential use in wound dressings. The hydrogel membranes involved multiple methods assess structural, mechanical, chemical properties, such as pH measurements, swelling, moisture content uptake, gel fraction, hydrolytic degradation, protein adsorption denaturation tests, rheological SEM, biocompatibility testing, scratch assay. obtained higher concentration (1 mg/mL) exhibited superior mechanical swelling index 264%, water 55%, lower degradation percentage. In terms inclusion ULV composition enhanced strength, Alginate + PVA 1.0ULV sample demonstrated greatest resistance deformation. All good cell viability above 70% no obvious morphological modifications. addition potentiates regenerative effect membranes. Subsequent studies will focus encapsulating bioactive compounds, investigating release behavior, evaluating active effects.

Language: Английский

Citations

1