Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150778 - 150778
Published: Oct. 1, 2024
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 6, 2025
Traumatic brain injury (TBI) represents a significant global public health issue, with effective management posing numerous challenges. The pathophysiology of TBI is typically categorized into two phases: primary and secondary injuries. Secondary involves pathophysiological mechanisms such as blood-brain barrier (BBB) disruption, mitochondrial dysfunction, oxidative stress, inflammatory responses. Current pharmacological strategies often encounter obstacles in treating effectively, primarily due to challenges BBB penetration, inadequate target site accumulation, off-target toxicity. Versatile hydrogels nanoparticles offer potential solutions these limitations. This review discusses recent progress utilizing for treatment over the past 5 years, highlighting their relevance underlying pathophysiology. Hydrogels demonstrate substantial promise addressing injury, providing broad spectrum future therapeutic opportunities.
Language: Английский
Citations
2
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 8, 2025
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in substantia nigra and accumulation α-synuclein aggregates known as Lewy bodies. MicroRNA-7 (miR-7) targets gene SNCA, which encodes α-synuclein, reducing its expression alleviating neuronal damage PD. Regulating post-transcriptional levels through miR-7 effectively inhibits production. Herein, we use nanodiamonds carriers to deliver (N-7), can protect neurons. Dopaminergic efficiently take up N-7 express miR-7. reduces oxidative stress restores dopamine effectively. These findings suggest that nanocomposites have significant potential treating
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 352 - 352
Published: March 9, 2025
Pharmaceutical 3D printing, combined with nanomaterials and nanodevices, presents a transformative approach to precision medicine for treating neurological diseases. This technology enables the creation of tailored dosage forms controlled release profiles, enhancing drug delivery across blood−brain barrier (BBB). The integration nanoparticles, such as poly lactic-co-glycolic acid (PLGA), chitosan, metallic nanomaterials, into 3D-printed scaffolds improves treatment efficacy by providing targeted prolonged release. Recent advances have demonstrated potential these systems in conditions like Parkinson’s disease, epilepsy, brain tumors. Moreover, printing allows multi-drug combinations personalized formulations that adapt individual patient needs. Novel approaches, including stimuli-responsive systems, on-demand dosing, theragnostics, provide new possibilities real-time monitoring disorders. Despite innovations, challenges remain terms scalability, regulatory approval, long-term safety. future perspectives this suggest its revolutionize treatments offering patient-specific therapies, improved penetration, enhanced outcomes. review discusses current state, applications, nanotechnology treatment, highlighting need further research overcome existing challenges.
Language: Английский
Citations
0
Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)
Published: April 1, 2025
ABSTRACT The rapid advancement of digital technologies has heightened the demand for multifunctional smart materials with adaptive and responsive capabilities. Among these, chromogenic hydrogel composites have emerged as promising candidates next‐generation applications due to their unique stimuli‐responsive behavior. These hydrogels exhibit dynamic optical changes in response external triggers such light, temperature, pH, humidity, mechanical stress, electric or magnetic fields, enabling a wide range functionalities data storage, security, authentication, anti‐counterfeiting technologies. This review provides comprehensive examination composites, focusing on fundamental design principles, mechanisms, emerging systems. categorizes these based response, including photochromic, hydrochromic, electrochromic, magnetochromic, thermochromic, tribochromic, mechanochromic systems, analyzing key material compositions functional characteristics. Furthermore, recent advances fabrication techniques 3D 4D printing, self‐healing networks, multi‐stimuli‐responsive are discussed, highlighting potential programmable displays, rewritable encrypted security Finally, identifies current challenges future directions field, emphasizing need enhanced durability, faster times, improved integration insights presented this work aim guide development innovative interactive intelligent materials.
Language: Английский
Citations
0
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150778 - 150778
Published: Oct. 1, 2024
Language: Английский
Citations
0