Regenerative Medicine in Plastic Surgery: The Role of Stem Cells and Bioprinting
Regenesis repair rehabilitation.,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
The Next Frontier in Aesthetics: 3D Bioprinting for Personalized Skin Regeneration
Journal of Cosmetic Dermatology,
Journal Year:
2025,
Volume and Issue:
24(4)
Published: March 26, 2025
Cosmetic
dermatology
is
entering
a
new
frontier
with
the
advent
of
3D
bioprinting,
technology
poised
to
revolutionize
way
we
approach
skin
regeneration,
aesthetic
enhancement,
and
personalized
dermatologic
interventions
[1].
While
initially
developed
for
reconstructive
applications,
bioprinted
may
soon
redefine
anti-aging
treatments,
scar
revision,
even
volumetric
facial
rejuvenation.
The
ability
print
customized
grafts
using
patient's
own
cells
presents
an
unprecedented
opportunity
natural,
long-lasting
results
that
go
beyond
current
injectables
or
energy-based
devices
[2].
Unlike
synthetic
fillers
collagen
stimulators,
bioengineered
has
potential
integrate
seamlessly
native
tissue,
not
just
restoring
lost
elasticity
improving
texture
but
also
offering
truly
volume
restoration
wrinkle
repair.
development
bioinks
composed
extracellular
matrix
components,
fibroblasts,
keratinocytes
made
it
possible
recreate
full-thickness
layers,
closely
mimicking
natural
architecture
[3].
This
breakthrough
paves
regenerative
therapies
tailored
unique
biology,
major
leap
from
primarily
focus
on
temporary
improvements.
Recent
studies
have
already
explored
possibility
bioprinting
constructs
replicate
biomechanical
pigmentation
properties,
which
could
provide
highly
solutions
ethnic
tones,
hyperpigmentation
disorders,
remodeling
[1,
4].
be
game
changer
in
treating
post-inflammatory
hyperpigmentation,
vitiligo,
burn
scars,
where
uniform
repigmentation
remains
significant
challenge.
What
if,
instead
depigmentation
camouflage
techniques,
bioprint
new,
pigment-matched
skin?
implications
are
enormous.
Beyond
direct
holds
promise
testing
cosmetic
formulations,
optimizing
post-procedure
recovery,
hosting
patient-specific
microbiomes.
Traditional
vitro
models
lack
complexity
real
skin,
limiting
predict
how
skincare
products,
fillers,
treatments
will
interact
human
tissue.
Bioprinted
bridge
this
gap,
serving
as
functional
platforms
eliminate
need
animal
more
accurate
insights
into
product
safety
efficacy
[5].
With
AI-driven
modeling,
future
regeneration
becomes
precise.
AI-assisted
tissue
engineering
optimize
scaffold
design,
ensuring
enhance
synthesis,
modulate
inflammation,
restore
dermal
[6].
manage
atrophic
keloids,
aging-related
loss,
moving
us
away
toward
long-term
regeneration.
possibilities
vast,
yet
surprisingly
underexplored
research.
Despite
its
promise,
raises
critical
questions
about
regulatory
pathways,
accessibility,
ethical
considerations.
Will
these
classified
medical
luxury
enhancements?
Could
customized,
youthful
fuel
unrealistic
expectations
medicine?
designer
aesthetics
shaping
beauty
trends
through
consultations,
far
patients
requesting
modifications
idealized
standards
rather
than
restoration?
These
dermatologists,
researchers,
policymakers
must
address
continues
advance.
Another
challenge
cost
accessibility.
widely
available,
expensive
largely
experimental.
become
niche
service
reserved
high-end
clinics,
advancements
biofabrication
make
scalable
accessible
broader
population?
considerations
taken
account
transitions
lab
clinical
practice.
field
continually
evolving,
now
time
start
conversation
reshape
treatment
paradigms.
create
personalized,
exciting
challenge,
one
lead
fundamental
shift
medicine.
As
progresses,
interdisciplinary
collaboration
crucial
bridging
gap
between
medicine,
dermatology,
biotechnology.
medicine
reversing
time,
bioengineering
evolve
it.
However,
further
research
essential
fully
understand
efficacy,
safety,
applications.
author
declares
no
conflicts
interest.
data
support
findings
study
available
references'
part.
Language: Английский
Recent Advances in Biomaterials and Device Technologies for Chronic Wound Healing and Tissue Repair
Treesa Varghese,
No information about this author
Beegam L. Ramlath,
No information about this author
M. Unnimaya
No information about this author
et al.
IGI Global eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 277 - 310
Published: April 25, 2025
Wound
healing
is
a
highly
complicated
event,
involving
re-vascularization,
and
re-epithelialization,
followed
by
cellular
proliferation,
tissue
remodeling.
Recent
technological
interventions
have
great
potential
in
managing
healthy
wound
environment,
thus
reducing
inflammation
time
while
promoting
repair.
In
addition,
these
inventions
enhance
the
biocompatibility
of
wounds
improve
patient's
quality
life.
Major
breakthroughs
include
self-healing
hydrogels,
hydrocolloids,
hydro-fibers,
surgical
sutures,
wearable
monitoring
systems,
environment-responsive
dressings,
negative
pressure
therapy
devices,
growth-factor-based
therapy,
gene
stem-cell
bioengineered
skin
substitutes.
This
chapter
discusses
recent
advancements
care
technologies,
focussing
on
biomaterials,
biomaterial
their
applications.
Language: Английский
The Future of Automated Tissue Engineering: Robotic‐Assisted Strategies for Complex 3D Tissue Bottom‐Up Assembly
Advanced Materials Technologies,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 4, 2025
Abstract
Over
the
years,
need
for
novel
solutions
to
replace
damaged
tissues
has
led
development
of
new
tissue‐engineering
strategies.
Bottom‐up
approaches
have
gained
interest
mimicking
hierarchical
cellular
organization
and
intricate
nature
tissues.
Among
these
approaches,
automated‐assisted
techniques,
such
as
robotic
handling,
potential
precisely
control
spatial
building
blocks,
allowing
creation
highly
specific
functional
Recognizing
handling
in
tissue
engineering,
this
review
provides
an
overview
robot‐assisted
bottom‐up
engineering
complex
tissues,
highlighting
advantages
limitations
various
systems
currently
being
explored.
To
address
growing
field,
also
discusses
key
considerations
assembly
living
while
providing
insights
into
future
directions
challenges
rapidly
evolving
field.
Language: Английский
Optimizing Wound Healing in Radial Forearm Donor Sites: A Comparative Study of Ulnar-Based Flap and Split-Thickness Skin Grafting
A Galazka,
No information about this author
Katarzyna Stawarz,
No information about this author
Karolina Bieńkowska‐Pluta
No information about this author
et al.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(5), P. 1131 - 1131
Published: May 7, 2025
Background:
The
radial
forearm
free
flap
(RFFF)
is
a
common
technique
in
head
and
neck
reconstructive
surgery.
This
study
aimed
to
compare
the
clinical
biochemical
outcomes
of
wound
healing
following
ulnar-based
transposition
(UBTF)
versus
split-thickness
skin
grafting
(STSG)
for
donor
site
closure,
with
particular
emphasis
on
tissue
regeneration.
Materials
Methods:
A
total
24
patients
(6
women,
18
men),
underwent
RFFF
reconstruction.
was
closed
using
UBTF
10
cases,
while
STSG
performed
14
cases.
Postoperative
complications—including
necrosis,
edema,
hematoma,
infection,
dehiscence—along
times
were
assessed
daily
during
first
seven
postoperative
days
at
monthly
follow-ups
over
six
months.
Pre-
analyses
included
hemoglobin
(HB),
white
blood
cell
count
(WBC),
platelets
(PLT),
albumin,
C-reactive
protein
(CRP)
levels.
An
aesthetic
evaluation
also
performed.
Results:
two
groups
homogeneous.
complications
occurred
more
frequently
group,
which
demonstrated
significantly
longer
(p
=
0.0004).
In
contrast,
group
showed
better
terms
color
0.000021),
texture
0.000018),
stability
0.0398).
Additionally,
pre-
PLT
counts
higher
0.001
p
0.043,
respectively).
Conclusions:
While
remains
well-established
method
closure
harvest,
this
demonstrates
that
viable
alternative
associated
outcomes.
Language: Английский