Recent advances in cutaneous drug delivery by iontophoresis DOI
Idejan P. Gross, Ana Luiza Lima, Lívia Cristina Lira de Sá Barreto

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Iontophoresis has been extensively studied for topical and transdermal drug delivery to stimulate the absorption of molecules that would hardly pass through outermost layer skin passively. Recent research focused on its combination with nanoparticle-based systems or microneedles expand therapeutic applications. This review explores fundamental principles iontophoresis, focusing key factors influencing transport mechanisms, provides a discussion field's current state. A comprehensive analysis articles published available online in 2024 was conducted, categorizing studies by their application areas, systems, iontophoretic conditions, experimental limitations. The findings reveal recent focus wound healing repair, advancements treating inflammation, pain, cancer. Market translation requires standardized protocols, particularly parameters preclinical models, along development cost-effective commercial devices. Additionally, while cutaneous have increasingly benefited from machine learning approaches, iontophoresis remains underexplored. With growing interest associating Internet Things, such an integration, if combined AI tools, could offer promising opportunities personalized, real-time treatments modern dermatology, systems.

Language: Английский

Recent advances in cutaneous drug delivery by iontophoresis DOI
Idejan P. Gross, Ana Luiza Lima, Lívia Cristina Lira de Sá Barreto

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Iontophoresis has been extensively studied for topical and transdermal drug delivery to stimulate the absorption of molecules that would hardly pass through outermost layer skin passively. Recent research focused on its combination with nanoparticle-based systems or microneedles expand therapeutic applications. This review explores fundamental principles iontophoresis, focusing key factors influencing transport mechanisms, provides a discussion field's current state. A comprehensive analysis articles published available online in 2024 was conducted, categorizing studies by their application areas, systems, iontophoretic conditions, experimental limitations. The findings reveal recent focus wound healing repair, advancements treating inflammation, pain, cancer. Market translation requires standardized protocols, particularly parameters preclinical models, along development cost-effective commercial devices. Additionally, while cutaneous have increasingly benefited from machine learning approaches, iontophoresis remains underexplored. With growing interest associating Internet Things, such an integration, if combined AI tools, could offer promising opportunities personalized, real-time treatments modern dermatology, systems.

Language: Английский

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