Targeting Reactive Oxygen Species for Diagnosis of Various Diseases DOI Creative Commons

Moung Young Lee,

Dong‐Uk Lee, Dong‐Kug Choi

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(12), P. 378 - 378

Published: Dec. 15, 2024

Reactive oxygen species (ROS) are generated predominantly during cellular respiration and play a significant role in signaling within the cell between cells. However, excessive accumulation of ROS can lead to dysfunction, disease progression, apoptosis that organ dysfunction. To overcome short half-life relatively small amount produced, various imaging methods have been developed, using both endogenous exogenous means monitor settings. In this review, we discuss molecular mechanisms underlying production explore materials could be used detect overproduction, including iron-based materials, ROS-responsive chemical bond containing polymers, molecule biomaterials. We also techniques target overproduction. potentials established clinical methods, such as magnetic resonance (MRI), sonographic imaging, fluorescence imaging. other photoacoustic (PAI) Raman (RI) currently preclinical stage discussed. Finally, paper focuses on diseases associated with current future applications ROS-targeted While most widely condition is cardiovascular diseases, its potential extends into non-cardiovascular conditions, neurovascular, neurodegenerative, ROS-associated cancers, skin aging, acute kidney injury, inflammatory arthritis.

Language: Английский

ROS-differentiated release of Apelin-13 from hydrogel comprehensively treats myocardial ischemia-reperfusion injury DOI

Penghao Zhen,

Qiaochu Jiang,

Fuchao Yu

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 609 - 620

Published: Jan. 24, 2025

Language: Английский

Citations

0
Cardiac Tissue Engineering Using Stimuli‐Responsive Biomaterials for the Targeted Therapy of Myocardial Infarction DOI Creative Commons
Zarin Tasnim Tisha,

Kazi Tasnuva Alam,

Tanvir Ahmed

et al.

MedComm – Biomaterials and Applications, Journal Year: 2025, Volume and Issue: 4(1)

Published: March 1, 2025

ABSTRACT Cardiac tissue engineering presents a viable strategy for the targeted therapy of myocardial infarction (MI), overcoming limitations existing therapies in cardiac repair and regeneration. This review explores potential stimuli‐responsive biomaterials that engage with environment by reacting to various environmental stimuli including pH, temperature, enzymes, ultrasound, reactive oxygen species. These materials enable precise drug delivery, modulate cellular responses, enhance Biomaterials such as hydrogels, polymers, chitosan, collagen, alginate improve accuracy effectiveness localized delivery drugs, stem cells, growth factors, thus improving precision efficacy treatments. The looks at ability these mimic complex biochemical mechanical cues healthy myocardium. challenges prospects clinical applications are discussed, highlighting their transformative while outcomes patients MI.

Language: Английский

Citations

0
Targeting Reactive Oxygen Species for Diagnosis of Various Diseases DOI Creative Commons

Moung Young Lee,

Dong‐Uk Lee, Dong‐Kug Choi

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(12), P. 378 - 378

Published: Dec. 15, 2024

Reactive oxygen species (ROS) are generated predominantly during cellular respiration and play a significant role in signaling within the cell between cells. However, excessive accumulation of ROS can lead to dysfunction, disease progression, apoptosis that organ dysfunction. To overcome short half-life relatively small amount produced, various imaging methods have been developed, using both endogenous exogenous means monitor settings. In this review, we discuss molecular mechanisms underlying production explore materials could be used detect overproduction, including iron-based materials, ROS-responsive chemical bond containing polymers, molecule biomaterials. We also techniques target overproduction. potentials established clinical methods, such as magnetic resonance (MRI), sonographic imaging, fluorescence imaging. other photoacoustic (PAI) Raman (RI) currently preclinical stage discussed. Finally, paper focuses on diseases associated with current future applications ROS-targeted While most widely condition is cardiovascular diseases, its potential extends into non-cardiovascular conditions, neurovascular, neurodegenerative, ROS-associated cancers, skin aging, acute kidney injury, inflammatory arthritis.

Language: Английский

Citations

1