Salivary Extracellular Vesicles in Detection of Head and Neck Cancers: A Systematic Review DOI Creative Commons

Wojciech Owecki,

Karolina Wojtowicz, Kacper Nijakowski

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 6757 - 6775

Published: May 1, 2025

Head and neck cancer (HNC) represents approximately 10% of all cases globally, posing a significant public health challenge. Despite advances in therapeutic approaches, the mortality rate associated with HNC continues to rise. A growing body research highlights role extracellular vesicles progression pathogenesis, positioning them as promising candidates for novel biomarker discovery. Concurrently, saliva has emerged valuable diagnostic fluid due its non-invasive, accessible, cost-effective collection methods. This systematic review aims explore potential salivary tools early detection monitoring head cancer. PubMed, Scopus, Web Science, Embase were thoroughly searched from database inception July 16, 2024. Twenty-three eligible studies included, focusing on original that described biomarkers HNC. In oral - predominantly represented by squamous cell carcinoma subtype several proteins, including PSB7, AMER3, LOXL2, well ten-protein panel, demonstrated strong biomarkers. Additionally, analysis various microRNAs (miR-140, miR-143, miR-145, miR-412-3p, miR-512-3p, miR-1307-5p) Fourier-transform infrared (FTIR) spectra shown results detection. For oropharyngeal cancer, lactate dehydrogenase B appears be biomarker. Another avenue is assessment human papillomavirus (HPV) risk development Four investigated without specifying location; however, limited or absent reporting sensitivity specificity hampers reliable evaluation conclusion, hold promise HNC, but further needed validate their utility.

Language: Английский

Extracellular vesicles: innovative cell-free solutions for wound repair DOI Creative Commons

Hanne Eerdekens,

Elke Pirlet, S. Willems

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 3, 2025

Chronic non-healing wounds are often associated with conditions such as diabetes and peripheral vascular disease, pose significant medical socioeconomic challenges. Cell-based therapies have shown promise in promoting wound healing but major drawbacks immunogenicity tumor formation. As a result, recent research has shifted to the potential of extracellular vesicles (EVs) derived from these cells. EVs nanosized lipid bilayer vesicles, naturally produced by all cell types, which facilitate intercellular communication carry bioactive molecules, offering advantages low immunogenicity, negligible toxicity be re-engineered. Recent evidence recognizes that during released wide range cells including immune cells, skin epithelial platelets they actively participate repair. This review comprehensively summarizes latest on function endogenous types different phases healing, thereby presenting interesting therapeutic targets. Additionally, it gives critical overview current status mesenchymal stem cell-derived treatment highlighting their tremendous non-cellular of-the-shelf alternative care.

Language: Английский

Citations

0
Salivary Extracellular Vesicles in Detection of Head and Neck Cancers: A Systematic Review DOI Creative Commons

Wojciech Owecki,

Karolina Wojtowicz, Kacper Nijakowski

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 6757 - 6775

Published: May 1, 2025

Head and neck cancer (HNC) represents approximately 10% of all cases globally, posing a significant public health challenge. Despite advances in therapeutic approaches, the mortality rate associated with HNC continues to rise. A growing body research highlights role extracellular vesicles progression pathogenesis, positioning them as promising candidates for novel biomarker discovery. Concurrently, saliva has emerged valuable diagnostic fluid due its non-invasive, accessible, cost-effective collection methods. This systematic review aims explore potential salivary tools early detection monitoring head cancer. PubMed, Scopus, Web Science, Embase were thoroughly searched from database inception July 16, 2024. Twenty-three eligible studies included, focusing on original that described biomarkers HNC. In oral - predominantly represented by squamous cell carcinoma subtype several proteins, including PSB7, AMER3, LOXL2, well ten-protein panel, demonstrated strong biomarkers. Additionally, analysis various microRNAs (miR-140, miR-143, miR-145, miR-412-3p, miR-512-3p, miR-1307-5p) Fourier-transform infrared (FTIR) spectra shown results detection. For oropharyngeal cancer, lactate dehydrogenase B appears be biomarker. Another avenue is assessment human papillomavirus (HPV) risk development Four investigated without specifying location; however, limited or absent reporting sensitivity specificity hampers reliable evaluation conclusion, hold promise HNC, but further needed validate their utility.

Language: Английский

Citations

0