Recent Advances in Photodynamic Therapy: Metal-Based Nanoparticles as Tools to Improve Cancer Therapy
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(7), P. 932 - 932
Published: July 12, 2024
Cancer
remains
a
significant
global
health
challenge,
with
traditional
therapies
like
surgery,
chemotherapy,
and
radiation
often
accompanied
by
systemic
toxicity
damage
to
healthy
tissues.
Despite
progress
in
treatment,
these
approaches
have
limitations
such
as
non-specific
targeting,
toxicity,
resistance
development
cancer
cells.
In
recent
years,
nanotechnology
has
emerged
revolutionary
frontier
therapy,
offering
potential
solutions
challenges.
Nanoparticles,
due
their
unique
physical
chemical
properties,
can
carry
therapeutic
payloads,
navigate
biological
barriers,
selectively
target
Metal-based
nanoparticles,
particular,
offer
properties
suitable
for
various
applications.
Recent
advancements
focused
on
the
integration
of
metal-based
nanoparticles
enhance
efficacy
precision
photodynamic
therapy.
Integrating
into
therapy
represents
paradigm
shift,
enabling
strategies
enhanced
specificity
reduced
off-target
effects.
This
review
aims
provide
comprehensive
understanding
pivotal
role
We
explore
mechanisms,
biocompatibility,
applications
highlighting
challenges
use,
well
combining
nanoparticles/photodynamic
other
synergistic
approach
treatment.
Language: Английский
Nanostructured Biomaterials in 3D Tumor Tissue Engineering Scaffolds: Regenerative Medicine and Immunotherapies
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5414 - 5414
Published: May 16, 2024
The
evaluation
of
nanostructured
biomaterials
and
medicines
is
associated
with
2D
cultures
that
provide
insight
into
biological
mechanisms
at
the
molecular
level,
while
critical
aspects
tumor
microenvironment
(TME)
are
provided
by
study
animal
xenograft
models.
More
realistic
models
can
histologically
reproduce
human
tumors
tissue
engineering
methods
co-culturing
cells
varied
phenotypes
to
3D
spheroids
recapitulate
dynamic
TME
in
matrices.
novel
approaches
creating
combined
(TTE)
scaffolds
including
hydrogels,
bioprinted
materials,
decellularized
tissues,
fibrous
This
review
focuses
on
use
materials
cancer
therapy
regeneration,
development
for
studying
immune
characteristics.
Tissue
regeneration
an
important
aspect
TTE
used
restoring
normal
function
providing
treatment.
Thus,
this
article
reports
recent
advancements
antitumor
drug
screening,
metastasis,
regeneration.
Also,
identifies
significant
opportunities
using
immunological
processes
involved
application
immunotherapies.
Language: Английский
Nanostructured Biomaterials in Tumor Tissue Engineering: Regenerative Medicine and Immunotherapies
Published: April 29, 2024
The
evaluation
of
nanostructured
biomaterials
and
medicines
is
associated
with
2D
cultures
that
provide
insight
into
the
biological
mechanisms
at
molecular
level,
while
critical
aspects
tumor
microenvironment
(TME)
are
provided
by
study
animal
xenograft
models.
More
realistic
models
can
histologically
reproduce
human
tumors
tissue
engineering
methodologies
co-culturing
cells
varied
phenotypes,
to
3D
spheroids
recapitulate
dynamic
TME
in
matrices.
novel
approaches
combined
(TTE)
scaffolds
including
hydrogels,
bioprinted
materials,
decellularized
tissues,
fibrous
This
review
focuses
on
use
materials
cancer
therapy
regeneration,
development
for
studying
immune
characteristics.
Tissue
regeneration
an
important
aspect
TTE
restoring
normal
function
providing
treatment.
Thus,
this
article
reports
recent
advancements
antitumor
drug
screening,
metastasis,
regeneration.
Also,
identifies
great
opportunities
immunological
processes
involved
application
immunotherapies.
Language: Английский