Death fuels growth: Emerging players bridging apoptosis and cell proliferation in Drosophila and beyond

Seminars in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 169, P. 103602 - 103602

Published: March 12, 2025

Tissue homeostasis relies on a delicate balance between cell death and proliferation. Apoptosis plays key role not only in removing damaged cells but also promoting tissue recovery through process known as apoptosis-induced proliferation (AiP). This review highlights how caspases, c-Jun N-terminal Kinase (JNK), Reactive Oxygen Species (ROS) bridge proliferation, revealed studies using Drosophila model organism. We compare these findings with advances other systems discuss their broader implications for regeneration tumorigenesis.

Language: Английский

Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons

Published: April 17, 2025

The nervous system undergoes functional modification independent on cell turn over. Caspase participates in reversible neuronal modulation via non-lethal activation. However, the mechanism that enables activation remains unclear. Here, we analyzed proximal proteins of Drosophila executioner caspase adult brain using TurboID. We discovered Drice is, as an inactive proform, to membrane proteins, including a specific splicing isoform adhesion molecule Fasciclin 3 (Fas3), Fas3G. To investigate whether sequestration plasma axons is for activation, developed Gal4-Manipulated Area-Specific CaspaseTracker/CasExpress sensitive monitoring activity near membrane. demonstrated Fas3G -overexpression promotes olfactory receptor neurons without killing them, by inducing expression initiator Dronc, which also comes close Physiologically, overexpression-facilitated suppresses innate attraction behavior. Our findings suggest subcellularly-restricted defined opening methodological development function regulating proteins.

Language: Английский

Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation inDrosophilaolfactory receptor neurons

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 20, 2023

Abstract The nervous system undergoes functional modification independent on cell turn over. Caspase participates in reversible neuronal modulation via non-lethal activation. However, the mechanism that enables activation remains unclear. Here, we analyzed proximal proteins of Drosophila executioner caspase adult brain using TurboID. We discovered Drice is, as an inactive proform, to membrane proteins, including a specific splicing isoform adhesion molecule Fasciclin 3 (Fas3), Fas3G. To investigate whether sequestration plasma axons is for activation, developed Gal4-Manipulated Area-Specific CaspaseTracker/CasExpress sensitive monitoring activity near membrane. demonstrated Fas3G -overexpression promotes olfactory receptor neurons without killing them, by inducing expression initiator Dronc, which also comes close Physiologically, overexpression-facilitated suppresses innate attraction behavior. Our findings suggest subcellularly-restricted defined opening methodological development function regulating proteins.

Language: Английский