DDR2 alleviates retinal vaso-obliteration and pathological neovascularization by modulating microglia M1/M2 phenotypic polarization in a mouse model of proliferative retinopathy DOI Creative Commons
Qinjin Dai, Wenqi Su, Zhongcheng Zhou

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(5), P. 167787 - 167787

Published: March 9, 2025

Retinopathy of prematurity (ROP), a leading cause blindness in premature infants, is characterized by retinal vaso-obliteration during hyperoxia and pathological neovascularization (NV) relative hypoxia phase. Current treatments, which focus on the late stages neovascularization, are associated with numerous side effects. Studies demonstrated that discoidin domain receptor 2 (DDR2), collagen-binding tyrosine kinase, inhibits experimental choroidal participates tumor angiogenesis. However, role DDR2 ROP underlying mechanisms unclear. In this study, we initially found expressed mouse physiological vascular development significantly decreased phase followed increase oxygen-induced retinopathy (OIR) model. Early upregulation before attenuates vaso-obliteration, reduces promotes maturation. Additionally, increased number microglia around blood vessels induced anti-inflammatory M2 polarization. Furthermore, STAT6/TGF-β signaling pathway suppressed was activated after upregulation. conclusion, attenuated inhibited switching polarization from M1 to phenotype via OIR. This suggests could be novel target for early treatment ROP.

Language: Английский

Glycosaminoglycans: Mechanisms and Therapeutic Potential in Neurological Diseases: A Mini-Review DOI
Shupeng Li, Iram Murtaza, Hongling Guo

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151861 - 151861

Published: April 1, 2025

Language: Английский

Citations

0
Molecular insights into the mechanism of white syndrome in Macrobrachium rosenbergii through transcriptome analysis DOI

Feiyang Wang,

Jinyi Liu,

Jianhu Jiang

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742605 - 742605

Published: April 1, 2025

Language: Английский

Citations

0
Characterization of the Limbal Epithelial Stem Cell Niche DOI Creative Commons
Isabel Y. Moreno,

Arian Parsaie,

Tarsis F. Gesteira

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2023, Volume and Issue: 64(13), P. 48 - 48

Published: Oct. 31, 2023

Limbal epithelial stem cells (LESCs) reside within a LSC niche (LSCN). We recently identified that hyaluronan (HA) is major constituent of the LSCN, and HA necessary for maintaining LESCs in "stem cell" state, both vitro vivo. Herein, we characterized LSCN to identify key components HA-specific LSCN.

Language: Английский

Citations

10
Serum decorin and biglycan levels as predictive biomarkers for lung fibrosis severity and mortality risk in COVID-19 patients DOI Creative Commons
Shaaf Ahmad, Kaleem Maqsood,

Farwa Liaqat

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 21, 2025

Introduction Individuals experiencing severe symptoms of COVID-19 are at the greatest risk developing post-COVID lung fibrosis, which significantly impacts long-term health outcomes. This study aims to investigate predictive potential serum biomarkers, specifically decorin and biglycan, in assessing severity mortality among patients. Methods For this study, healthy controls patients ( n = 240) them 186 with moderate 54 from Ittefaq Hospital Mayo Hospital, Lahore, Pakistan were recruited satisfying inclusion exclusion criteria. Patients followed up for 2 months. Serum level biglycan was evaluated by ELISA. One-way ANOVA Independent sample “ t ”-test applied significance p < 0.05 using GraphPad Prism. Results Decorin levels decreased (43.36 ± 1.14 ng/mL) (40.24 0.64 (35.49 1.00 0.0059). Biglycan increased (66.15 2.22 pg/mL) (70.02 1.57 (75.88 1.97 0.0042). In follow-up, survivors had higher (39.6 0.59 than non-survivors (35.84 1.61 0.0319). similar between (70.98 1.41 (73.99 3.24 0.459). Higher correlate survival Conclusion valuable biomarkers predicting Lower disease severity, emphasizing their identify fibrosis guide clinical management.

Language: Английский

Citations

0
DDR2 alleviates retinal vaso-obliteration and pathological neovascularization by modulating microglia M1/M2 phenotypic polarization in a mouse model of proliferative retinopathy DOI Creative Commons
Qinjin Dai, Wenqi Su, Zhongcheng Zhou

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(5), P. 167787 - 167787

Published: March 9, 2025

Retinopathy of prematurity (ROP), a leading cause blindness in premature infants, is characterized by retinal vaso-obliteration during hyperoxia and pathological neovascularization (NV) relative hypoxia phase. Current treatments, which focus on the late stages neovascularization, are associated with numerous side effects. Studies demonstrated that discoidin domain receptor 2 (DDR2), collagen-binding tyrosine kinase, inhibits experimental choroidal participates tumor angiogenesis. However, role DDR2 ROP underlying mechanisms unclear. In this study, we initially found expressed mouse physiological vascular development significantly decreased phase followed increase oxygen-induced retinopathy (OIR) model. Early upregulation before attenuates vaso-obliteration, reduces promotes maturation. Additionally, increased number microglia around blood vessels induced anti-inflammatory M2 polarization. Furthermore, STAT6/TGF-β signaling pathway suppressed was activated after upregulation. conclusion, attenuated inhibited switching polarization from M1 to phenotype via OIR. This suggests could be novel target for early treatment ROP.

Language: Английский

Citations

0