iScience, Journal Year: 2022, Volume and Issue: 25(9), P. 105027 - 105027
Published: Aug. 28, 2022
Language: Английский
eLife, Journal Year: 2023, Volume and Issue: 12
Published: Oct. 2, 2023
The heteroplasmic state of eukaryotic cells allows for cryptic accumulation defective mitochondrial genomes (mtDNA). 'Purifying selection' mechanisms operate to remove such dysfunctional mtDNAs. We found that activators programmed cell death (PCD), including the CED-3 and CSP-1 caspases, BH3-only protein CED-13, PCD corpse engulfment factors, are required in C. elegans attenuate germline abundance a 3.1-kb mtDNA deletion mutation, uaDf5, which is normally stably maintained heteroplasmy with wildtype mtDNA. In contrast, removal CED-4/Apaf1 or mutation CED-4-interacting prodomain CED-3, do not increase mtDNA, suggesting induction non-canonical mechanism non-apoptotic action CED-13/caspase axis. also mtDNAuaDf5 reproducibly increases age mothers. This effect transmitted offspring mothers, only partial intergenerational mutants elevated levels, this enhanced older an age-dependent quality control. Indeed, we both steady-state rates uaDf5 markedly decreased long-lived, increased short-lived, mutants. These findings reveal regulators aging program control its transmission.
Language: Английский
Citations
6
Journal of Zoology, Journal Year: 2023, Volume and Issue: 321(1), P. 1 - 21
Published: Aug. 3, 2023
Abstract In some species, permanent curtailment of reproduction part‐way through the lifespan adult females is a feature their evolved life history. The existence such post‐reproductive stage apparently rare; reasonably robust evidence for this confined to only six species (humans, Asian elephants and four whales). That it occurs at all appears contradict our view natural selection operating maximize fitness special circumstances must exist explain its occurrence. We evaluate main hypotheses posited evolution stage, why in restricted group animals, females. bring together literature from multiple biological disciplines levels enquiry, ranging evolutionary ecology, developmental biology, physiology, neuroscience, molecular human medicine. conclude that while time‐limited fertility not itself adaptive, duration subsequent survival likely be linked inclusive benefits. present new hypothesis which posits female certain long‐lived, highly encephalised with no post‐natal oogenesis, limited by need intense screening oocyte mitochondria. This required support endothermy coupled very high energy requirement development maintenance exceptionally large brain size complex social living. limits number shelf‐life oocytes, creating an antagonistically pleotropic effect beneficial production performing offspring but carries later cost fertility. But end fertile period time die. Inclusive benefits arising protracted parental care offspring, overlapping generations, kin structures means continued favoured selection. suggest further lines research test these ideas.
Language: Английский
Citations
5
Current Opinion in Environmental Science & Health, Journal Year: 2022, Volume and Issue: 29, P. 100377 - 100377
Published: June 22, 2022
Language: Английский
Citations
8
Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(30)
Published: July 16, 2024
As cells age, they undergo a remarkable global change: In transcriptional drift, hundreds of genes become overexpressed while others underexpressed. Using archetype modeling and Gene Ontology analysis on data from aging Caenorhabditis elegans worms, we find that the up-regulated code for sensory proteins upstream stress responses down-regulated are growth- metabolism-related. We observe similar trends within human fibroblasts, suggesting this process is conserved in higher organisms. propose simple mechanistic model how such coordination multiprotein expression levels may be achieved by binding single factor concentrates with age C. . A key implication cell’s own part its process, so unlike wear-and-tear processes, intervention might able to modulate these effects.
Language: Английский
Citations
1
iScience, Journal Year: 2022, Volume and Issue: 25(9), P. 105027 - 105027
Published: Aug. 28, 2022
Language: Английский
Citations
6