Late effects, long‐term problems and unmet needs of cancer survivors

International Journal of Cancer, Journal Year: 2022, Volume and Issue: 151(8), P. 1280 - 1290

Published: June 3, 2022

Great efforts are being made in cancer treatment, with impressive improvement survival. The situation concerning research and care for long-term problems late effects the growing population of survivors, however, is unsatisfactory. Therefore, FiX survey 1348 disease-free survivors about 4 years after diagnosis different types were asked to rate existing burdens support received them along a list 36 potential problems. Health-related quality life (HRQoL) was assessed EORTC QLQ-C30. Determinants explored using logistic regression analysis. While survivors' global HRQoL, physical role function ratings comparable or better than age- sex-matched reference values general population, emotional cognitive worse, especially among women (P < .01). Most frequently reported at least moderate burden loss performance (36.3%), fatigue (35.1%), sexual (34.7%), sleep (34.1%), arthralgia (33.8%), anxiety (28.0%), neuropathy (25.6%), memory (23.0%) concentration (21.9%). Burdened often rated as poor, regarding that physicians might consider medically nonthreatening, which no effective pharmacologic medical treatment known. included higher age, female gender, having ever chemotherapy overweight/obesity. In conclusion, significant number suffer from have unmet needs. Awareness health professionals should be increased these issues. results our study can contribute development targeted survivorship plans.

Language: Английский

---

Can a physical activity program improve functional capacity and fatigue in people with cancer? A retrospective analysis

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 6, 2025

Abstract Purpose The primary aim was to determine the effect of a physical activity (PA) program with education sessions on walking capacity and fatigue in people cancer. secondary objective assess factors that moderated program’s among sociodemographic, symptom-related factors. Satisfaction also evaluated. Method A retrospective, observational study data from 12-week twice-weekly group PA combined conducted. 6-min walk test (6MWT), Multidimensional Fatigue Inventory (MFI-20) satisfaction were assessed. Paired t-tests applied changes 6MWT MFI-20. Multiple linear regressions influence age, gender, initial effects program. Results Among 264 participants (age 57.36 ± 12.43 years; 189 women; 134 breast cancer), 125 (47%) completed Walking (+ 41.63 91.00 m) (-2.01 3.77) improved after ( p < 0.001). Age gender did not effect; however, lower higher scores associated larger improvements high who it. Conclusions significantly program, but drop-out rate high. could be individualized based an individual's or score enhance its effectiveness.

Language: Английский

---

A New Approach to Understanding Cancer-Related Fatigue: Leveraging the 3P Model to Facilitate Risk Prediction and Clinical Care

Cancers, Journal Year: 2022, Volume and Issue: 14(8), P. 1982 - 1982

Published: April 14, 2022

A major gap impeding development of new treatments for cancer-related fatigue is an inadequate understanding the complex biological, clinical, demographic, and lifestyle mechanisms underlying fatigue. In this paper, we describe a application comprehensive model fatigue: predisposing, precipitating, perpetuating (3P) factors model. This framework outlined herein, which incorporates emerging field metabolomics, may help to frame more in-depth analysis etiology as well broader personalized set approaches clinical treatment in oncology care. Included within review paper description proposed biological fatigue, presentation 3P model’s phenomenon. We conclude that focus on organization risk stratification around be warranted, future research benefit from expanding understand not only oncology, but also across variety chronic conditions.

Language: Английский

---

Chemotherapy impairs skeletal muscle mitochondrial homeostasis in early breast cancer patients

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 13(3), P. 1896 - 1907

Published: April 4, 2022

Language: Английский

---

Chemotherapy-Induced Molecular Changes in Skeletal Muscle

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 905 - 905

Published: March 15, 2023

Paraneoplastic conditions such as cancer cachexia are often exacerbated by chemotherapy, which affects the patient’s quality of life well response to therapy. The aim this narrative review was overview body-composition-related changes and molecular effects different chemotherapy agents used in treatment on skeletal-muscle remodeling. A literature search performed using Web Science, Scopus, Science Direct databases a total 77 papers retrieved. In general, survey showed that induced skeletal muscle have been studied mainly animal models mostly non-tumor-bearing rodents, whereas clinical studies essentially assessed body composition computerized tomography. Data from preclinical modulates several pathways muscle, including ubiquitin–proteasome pathway, autophagy, IGF-1/PI3K/Akt/mTOR, IL-6/JAK/STAT, NF-κB pathway; however, newest underexplored. conclusion, exacerbates wasting patients; incomplete characterization chemotherapy-related makes development new preventive anti-wasting strategies difficult. Therefore, further investigation mechanisms necessary.

Language: Английский

---

A single chemotherapy administration induces muscle atrophy, mitochondrial alterations and apoptosis in breast cancer patients

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: 15(1), P. 292 - 305

Published: Jan. 6, 2024

Abstract Background Breast cancer patients are commonly treated with sequential administrations of epirubicin–cyclophosphamide (EC) and paclitaxel (TAX). The chronic effect this treatment induces skeletal muscle alterations, but the specific each chemotherapy agent is unknown. This study aimed to investigate EC or TAX administration on homeostasis in breast patients. Methods Twenty early undergoing followed by chemotherapies were included. Two groups 10 women established performed vastus lateralis biopsies either before first (pre) (50 ± 14 years) 16 4 days later (post). Mitochondrial respiratory capacity recording, reactive oxygen species production, western blotting histological analyses performed. Results Decrease fibres cross‐sectional area was only observed post‐EC (−25%; P < 0.001), associated a reduction mitochondrial for complex I (CI)‐linked substrate state (−32%; = oxidative phosphorylation (OXPHOS) CI (−35%; 0.002), CI&CII (−26%; 0.022) CII (−24%; 0.027). If H 2 O production unchanged post‐EC, an increase post‐TAX OXPHOS (+25%; 0.022). We found decrease makers content, as shown protein levels citrate synthase (−53%; 0.001) VDAC (−39%; 0.001). Despite no changes markers fission, expression marker inner‐membrane fusion (OPA1; −60%; explored mitophagy reductions PINK1 (−63%; Parkin (−56%; 0.005), without post‐TAX. An increasing trend Bax level (+96%; 0.068) (+77%; 0.073), while Bcl‐2 decreased (−52%; 0.007). TUNEL‐positive signal (+68%; 0.082), upregulation highlighted (+86%; suggesting activation apoptosis process. Conclusions demonstrated that single induced, days, atrophy alterations These characterized function content well impairment dynamics apoptosis. did not worsen these group had already received during preceding weeks. However, it resulted increased apoptosis, likely response production.

Language: Английский

---

Restoring Skeletal Muscle Health through Exercise in Breast Cancer Patients and after Receiving Chemotherapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7533 - 7533

Published: July 9, 2024

Breast cancer (BC) stands out as the most commonly type of diagnosed in women worldwide, and chemotherapy, a key component treatment, exacerbates cancer-induced skeletal muscle wasting, contributing to adverse health outcomes. Notably, impact chemotherapy on seems surpass that itself, with inflammation identified common trigger for wasting both contexts. In muscle, pro-inflammatory cytokines modulate pathways crucial delicate balance between protein synthesis breakdown, well satellite cell activation myonuclear accretion. Physical exercise consistently emerges therapeutic strategy counteract chemotherapy-induced ultimately enhancing patients’ quality life. However, “one size fits all” approach does not apply prescription BC patients, factors such age, menopause comorbidities influencing response exercise. Hence, tailored regimens, considering duration, frequency, intensity, type, are essential maximize efficacy mitigating improving disease Despite well-established anti-inflammatory role aerobic exercise, resistance proves equally or more beneficial terms mass strength gain, This review comprehensively explores molecular affected by distinct regimens patients during providing critical insights precise implementation prevent wasting.

Language: Английский

---

Early skeletal muscle deconditioning and reduced exercise capacity during (neo)adjuvant chemotherapy in patients with breast cancer

Cancer, Journal Year: 2022, Volume and Issue: 129(2), P. 215 - 225

Published: Nov. 17, 2022

Abstract Background Fatigue is a hallmark of breast cancer and associated with skeletal muscle deconditioning. If cancer‐related fatigue occurs early during chemotherapy (CT), the development deconditioning its effect on exercise capacity remain unclear. The aim this study was to investigate evolution in patients early‐stage CT. Methods Patients had visit before undergoing CT, at 8 weeks, end (post‐CT). Body composition determined through bioelectrical impedance analysis. Knee extensor, handgrip force quantified by performing maximal voluntary isometric contractions using 6‐min walking test. Questionnaires were also administered evaluate quality life, fatigue, physical activity level. Results Among 100 patients, reductions found mass (−2.3%, p = .002), (−6.7%, < .001), knee extensor (−4.9%, .001) post‐CT, which occurred within first weeks treatment no further decrease thereafter. did not change, decreased post‐CT only (−2.5%, continued between (−4.6%, .001). Quality life impaired after ( remained stable thereafter, whereas level chemotherapy. Conclusions Similar reduced Thus, it appears essential prevent these alterations training implemented

Language: Английский

---

The Role of Exercise in Cancer-Related Sarcopenia and Sarcopenic Obesity

Cancers, Journal Year: 2023, Volume and Issue: 15(24), P. 5856 - 5856

Published: Dec. 15, 2023

One of the most common adverse effects cancer and its therapeutic strategies is sarcopenia, a condition which characterised by excess muscle wasting strength loss due to disrupted homeostasis. Moreover, cancer-related sarcopenia may be combined with increased deposition fat mass, syndrome called cancer-associated sarcopenic obesity. Both clinical conditions have significant importance can predict disease progression survival. A growing body evidence supports claim that physical exercise safe effective complementary therapy for oncology patients limit cancer- treatment-related catabolism promote maintenance mass. even after onset interventions counterbalance mass improve appearance quality life patients. The aim this narrative review was describe various pathophysiological mechanisms, such as protein synthesis, mitochondrial function, inflammatory response, hypothalamic-pituitary-adrenal axis, are regulated contribute management myokines, factors produced released from exercising muscles, being discussed they appear play an important role in mediating beneficial against sarcopenia.

Language: Английский

---

Age, cancer, and the dual burden of cancer and doxorubicin in skeletal muscle wasting in female rats: which one to blame?

Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 24, 2025

Language: Английский

---