Experimental Gerontology, Journal Year: 2022, Volume and Issue: 167, P. 111900 - 111900
Published: July 20, 2022
Language: Английский
Expert Review of Clinical Immunology, Journal Year: 2022, Volume and Issue: 18(9), P. 961 - 981
Published: July 25, 2022
Introduction Aging causes several changes in the immune system, although aging is strongly influenced by individual immunological history, as well genetic and environmental factors leading to inter-individual variability.Areas covered We focused on biological clinical meaning of immunosenescence. SARS-CoV-2 Yellow Fever vaccine have demonstrated relevance immunosenescence, while inconsistent results, obtained from longitudinal studies aimed at looking for risk phenotypes, revealed that immunosenescence highly context-dependent. Large projects allowed delineation drivers system variance, including factors, sex, smoking, co-habitation. Therefore, it difficult identify interventions can be envisaged maintain or improve function older people. That suggests drug treatment should require personalized intervention. Regarding this, we discussed role lifestyle a potential therapeutic approach.Expert opinion Our review points out age only part problem Everyone ages differently because unique genetics experience life this applies even more (immunobiography). Finally, shows how appreciable results modification biomarkers achieved with modification.
Language: Английский
Citations
29
Frontiers in Aging, Journal Year: 2023, Volume and Issue: 4
Published: Nov. 28, 2023
The proposed review aims to elucidate the intricate interplay between biological factors (sex differences) and socially constructed (gender in context of immune aging. While influence differences men women on various aspects responses has long been recognized, it is crucial acknowledge that gender, encompassing social cultural roles expectations associated with being male or female, also significantly shapes these processes. Gender can either accelerate aging promote longevity. By recognizing impact both factors, this work seeks offer a comprehensive understanding why may experience divergent trajectories varying outcomes terms Discrepancies perceived sexes, within families at work, contribute differing patterns antigen exposure. Additionally, variations micronutrient intake access preventive healthcare facilities exist. Health promotion knowledge often correlates educational attainment, which unequally represented males females many cultures across generations Western world. In countries without universal system, relies family prioritization strategies cope economic constraints, potentially limiting specific treatments affecting negatively. As result, behavioral gender disparities responses, susceptibility infections, autoimmune diseases, vaccine among older individuals. However, as demonstrated by COVID-19 pandemic, exhibit greater resilience infections than males. Given role system achieving longevity, not surprising live longer men, number female centenarians surpasses centenarians.
Language: Английский
Citations
22
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2638 - 2638
Published: Jan. 30, 2023
In the present paper, we have analysed role of age and sex in fatal outcome COVID-19, as there are conflicting results literature. As such, answered three controversial questions regarding this aspect COVID-19 pandemic: (1) Have women been more resilient than men? (2) Did centenarians die less remaining older people? (3) Were resistant to SARS-CoV-2 younger centenarians? The literature review demonstrated that: it is who resilient, agreement with data showing that live longer men even during severe famines epidemics; however, centenarian men; overall did not people, likely linked their frailty; first pandemic wave 2020, > 101 years old (i.e., born before 1919), but "younger centenarians", may be related 1918 Spanish flu epidemic, although unclear what mechanisms might involved.
Language: Английский
Citations
18
Immunity & Ageing, Journal Year: 2024, Volume and Issue: 21(1)
Published: June 27, 2024
Although it is well known that the older people have been most susceptible to COVID-19, there are conflicting data on susceptibility of centenarians. Two epidemiological study shown centenarians (> 101 years old at time 2020 pandemic peak) more resilient than remaining centenarians, suggesting this resilience might be linked 1918 Spanish Flu pandemic. To gain insight into matter, specifically whether SARS-CoV-2 infection they had affected by, we conducted a retrospective serological study. This examined serum samples from 33 encompassing semi- (aged > 104 < 110 years, N = 7) and supercentenarians 109 4), born between 1905 1922, against both H1N1 pseudotype virus.
Language: Английский
Citations
5
Physiology International, Journal Year: 2022, Volume and Issue: 109(2), P. 177 - 185
Published: May 16, 2022
COVID-19 has become a great burden of the world in respect health care, social, and economical reason. Several million people died worldwide so far more mutants are generated spread. Older with co-morbidities frailty syndrome have significantly higher risk to get infection also serious disease process. Mortality is case geriatric patients. In this review we attempted summarize factors susceptibility for disease, what actions need be taken defending older patients special aspects clinical presentation including ophthalmic symptoms.
Language: Английский
Citations
21
Aging Clinical and Experimental Research, Journal Year: 2022, Volume and Issue: 35(1), P. 217 - 220
Published: Nov. 1, 2022
Language: Английский
Citations
17
Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(9)
Published: Sept. 26, 2023
During aging, the immune system (IS) undergoes remarkable changes known as immunosenescence, a multifactorial and dynamic phenomenon that affects both natural acquired immunity plays an important role in most chronic diseases older people. Among determinants of we find low-grade sterile inflammation, “inflamm-aging”. This condition inflammation causes progressive reduction ability to trigger antibody cellular responses effective against infections vaccinations. In this review, wanted explore immunosenescence inflamm-aging immunological aging process predisposing viral phenomena, with particular reference cytomegalovirus (CMV), varicella zoster virus (VZV), influenza (IFV) SARS-CoV2. IS is also reflected response vaccinations, hence there need expand trials elderly patients, order identify appropriate methods for developing safe vaccination preventive strategies.
Language: Английский
Citations
7
Rejuvenation Research, Journal Year: 2022, Volume and Issue: 25(3), P. 129 - 140
Published: May 16, 2022
COVID-19 may have a heterogeneous onset, especially in older age. However, whether and how signs symptoms present aggregate together according to sociodemographic health factors is unclear, as well their prognostic value. This study included 981 inpatients who participated the GeroCovid Observational study. Signs/symptoms at disease sociodemographic, health, cognitive status, mobility were systematically recorded. Clusters of signs/symptoms identified through agglomerative hierarchical clustering. The associations single symptom clusters with longer hospitalization (≥16 days) in-hospital mortality explored logistic Cox regressions. most reported our sample (age 78.3 ± 9.39 years; 49.4% women) fever (62.5%), cough (45.5%), dyspnea (62.7%). Atypical by up one-third patients, delirium 9.1%. more frequent advancing age lower pre-COVID-19 levels. Older men likely respiratory than women. Dyspnea (hazard ratio [HR] = 1.47, 95% confidence interval [CI]: 1.02-2.12), tachypnea (HR 1.53, CI: 1.14-2.07), low oxygen saturation 1.95, 1.32-2.88) 1.60, 1.13-2.28) associated higher mortality. Four identified. Compared mild cluster, severe clinical impairment cluster was 2.57, 1.58-4.18). aspecific (odds [OR] 2.38, 1.56-3.63, OR 1.75, 1.08-2.83, respectively). Multiple aspects influence presentation. A approach help predict adverse outcomes patients. In addition symptoms, independently risk. ClinicalTrials.gov (NCT04379440).
Language: Английский
Citations
7
Chinese Medical Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 16, 2024
Abstract The rise in global life expectancy has led to an increase the older population, presenting significant challenges managing infectious diseases. Aging affects innate and adaptive immune systems, resulting chronic low-grade inflammation (inflammaging) function decline (immunosenescence). These changes would impair defense mechanisms, susceptibility infections reduce vaccine efficacy adults. Cellular senescence exacerbates these issues by releasing pro-inflammatory factors, further perpetuating inflammation. Moreover, comorbidities, such as cardiovascular disease diabetes, which are common adults, amplify dysfunction, while immunosuppressive medications complicate responses infections. This review explores molecular cellular mechanisms driving inflammaging immunosenescence, focusing on genomic instability, telomere attrition, mitochondrial dysfunction. Additionally, we discussed how aging-associated alterations influence bacterial, viral, parasitic evaluated emerging antiaging strategies, aimed at mitigating effects improve health outcomes aging population.
Language: Английский
Citations
1
Journal of the American Geriatrics Society, Journal Year: 2021, Volume and Issue: 70(3), P. 650 - 658
Published: Dec. 11, 2021
Abstract Background There is incomplete information regarding evolution of antibody titers against SARS‐CoV‐2 after a two‐dose strategy vaccination with BNT162b2 in older adults long‐term care facilities (LTCFs) frailty, disability, or cognitive impairment. We aimed to determine IgG titer loss LTCFs. Methods This multicenter longitudinal cohort study including 127 residents (90 females and 37 males) mean age 82.7 years (range 65–99) different frailty disability profiles two LTCFs Albacete, Spain. Residents received doses as per label, levels were determined 1 6 months the second dose. Age, sex, previous history coronavirus disease 2019 (COVID‐19), comorbidity (Charlson Index), performance activities daily living (Barthel (FRAIL instrument), status assessed. Results The vaccine dose 32,145 AU/ml (SD 41,206) 6182 13,316), respectively. Across all participants, median measured 77.6% (interquartile range [IQR] 23.8%). Notably, decline individuals pre‐vaccination COVID‐19 infection was significantly lower than those without (72.2% vs. 85.3%; p < 0.001). decrease follow‐up day 0.47% (IQR 0.14%) only associated rate at (hazard ratio 0.17; 95% confidence interval 0.07–0.41; Frailty, age, impairment, not extent loss. Conclusions Older experience rapid antibodies over first vaccine. Only slower decrease. Our data support immunization third this vulnerable, high‐risk population.
Language: Английский
Citations
9