CircRNAs: Roles in regulating head and neck squamous cell carcinoma DOI Creative Commons
Xiao Han,

Ruxian Tian,

Cai Wang

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Nov. 22, 2022

Head and neck squamous cell carcinoma (HNSCC), the most common head malignant tumor, with only monotherapy, is characterized by poor prognosis, low 5-year survival rate. Due to lack of therapeutic targets, targeted drugs for HNSCC are rare. Therefore, exploring regulation mechanism identifying effective targets will be beneficial its treatment of. Circular RNA (CircRNA) a class molecules circular structure, which widely expressed in human body. CircRNAs regulate gene expression exerting function as miRNA sponge, thereby mediating occurrence development proliferation, apoptosis, migration, invasion, other processes. In addition, circRNAs also involved tumor sensitivity chemical biological functions. this review, we systematically listed functions explored regulatory mechanisms from aspects growth, death, angiogenesis, invasion metastasis, stem regulation, drug resistance, immune escape, microenvironment. It assist us discovering new diagnostic markers while encourage ideas diagnosis HNSCC.

Language: Английский

The circ-PITX1 promotes non-small cell lung cancer development via the miR-30e-5p/ITGA6 axis DOI Creative Commons
Wei Li, Yang Pan,

Chucheng Zhong

et al.

Cell Cycle, Journal Year: 2022, Volume and Issue: 21(3), P. 304 - 321

Published: Jan. 10, 2022

Non-small cell lung cancer (NSCLC) is one of the most prevalent tumors with high incidence and mortality across globe. Recently, increasing studies have demonstrated that circular RNAs (circRNAs) exert outstanding functions in NSCLC progression. Notwithstanding, we are still dark about function exact mechanism circ-PITX1, a newly discovered circRNA. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) confirmed profile circ-PITX1 tissues adjacent normal tissues. Gain- loss- assay verified impact miR-30e-5p on proliferation, invasion, migration cells (H1975 A549). Bioinformatics analysis corroborated downstream mechanisms circ-PITX1. Dual-luciferase reporter gene RNA immunoprecipitation (RIP) examined interactions between miR-30e-5p, ITGA6. The protein levels ITGA6, PI3K, AKT were determined by Western blot. was substantially up-regulated cells, up-regulation correlated patients' poor survival. Functionally, overexpression or inhibition markedly facilitated migration, epithelial-mesenchymal transition (EMT), reduced apoptosis, enhanced ITGA6/PI3K/AKT expression whereas knockdown resulted opposite results. Mechanistically, acted as sponge which targeted 3ʹuntranslated region (UTR) Knockdown overexpressing axis. modulates miR-30e-5p/ITGA6 axis to boost progression, hence functioning an oncogene.

Language: Английский

Citations

18
Piezoelectric nanofilms fabricated by coaxial electrospun polycaprolactone/Barium titanate promote Achilles tendon regeneration by reducing IL-17A/NF-κB-mediated inflammation DOI
Wufei Dai, Qi Xu, Qinglin Li

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 1 - 22

Published: March 1, 2025

Language: Английский

Citations

0
Linc-PINT downregulation of TGF-β signaling pathway in heart arrhythmia: an in silico analysis DOI

Arash Amin,

Mahya Bakhshi Ardakani,

Maryam Saadatakhtar

et al.

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 1, 2025

Language: Английский

Citations

0
Hsa_circular RNA_0045474 Facilitates Osteoarthritis Via Modulating microRNA-485-3p and Augmenting Transcription Factor 4 DOI
Zhenxing Zhang,

PingHua Yu,

L BAI

et al.

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: 66(5), P. 1174 - 1187

Published: Jan. 11, 2024

Language: Английский

Citations

3
Exploration of lncRNA/circRNA-miRNA-mRNA network in patients with chronic atrophic gastritis in Tibetan plateau areas based on DNBSEQ-G99 RNA sequencing DOI Creative Commons
Wen Pan, Chao Liu, Tao Ren

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 22, 2024

Abstract A higher incidence of chronic atrophic gastritis (CAG) is generally considered as a precancerous lesion in gastric cancer (GC). The aim this study was to identify potential molecules involved the pathogenesis CAG Tibetan plateau, hoping help diagnosis and management disease. Atrophic non-atrophic mucosal tissue samples were collected from seven patients with (CG). Differentially expressed lncRNAs, circRNAs, miRNAs, mRNAs between (CNAG) groups identified based on DNBSEQ-G99 RNA sequencing. Subsequently, competitive endogenous (ceRNA) regulatory networks (lncRNA/circRNA-miRNA-mRNA networks) constructed. Two datasets (GSE153224 GSE163416), involving data non-Tibetan plateau areas, used further screen out key mRNAs, followed by common genes ferroptosis-related also identified. Functional enrichment analyses performed investigate biological functions CAG. total lncRNA-miRNA-mRNA relationship pairs 424 circRNA-miRNA-mRNA study. hsa_circ_0082984-hsa-miR-204-5p-CACNG8, lncRNA DRAIC/has_circ_0008561-hsa-miR-34a-5p-AR/GXYLT2, GAS1RR/RGMB-AS1/hsa_circ_0008561-hsa-miR-3614-5p-TMEM216/SUSD5, LINC00941/hsa_circ_0082984-hsa-miR-873-3p-TMC5 can be Additionally, eight differentially (DEmRNAs) (CBS, SLC2A4, STAT3, ALOX15B, ATF3, IDO1, NOX4, SOCS1) DEmRNAs play role JAK-STAT signaling pathway. This important molecular biomarkers that may regulating pathological mechanisms which provides research directions for future research.

Language: Английский

Citations

2
The role of extracellular vesicles in pyroptosis-mediated infectious and non-infectious diseases DOI

Cai‐Hua Zhang,

Ding-Ci Lu,

Ying Liu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 138, P. 112633 - 112633

Published: July 9, 2024

Language: Английский

Citations

2
The emerging role of miRNAs in pituitary adenomas: From molecular signatures to diagnostic potential DOI
Ahmed S. Doghish, Gharieb S. El‐Sayyad, Sherif S. Abdel Mageed

et al.

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 442(2), P. 114279 - 114279

Published: Oct. 1, 2024

Language: Английский

Citations

2
The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration DOI Creative Commons

Chao Jiang,

Zhe Chen, Xiaohui Wang

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 8, 2022

Low back pain (LBP) is one of the most common musculoskeletal symptoms and severely affects patient quality life. The majority people may suffer from LBP during their life-span, which leading to huge economic burdens family society. According series previous studies, intervertebral disc degeneration (IDD) considered as major contributor resulting in LBP. Furthermore, non-coding RNAs (ncRNAs), mainly including microRNAs (miRNAs), long noncoding (lncRNAs) circular (circRNAs), can regulate diverse cellular processes, have been found play pivotal roles development IDD. However, potential mechanisms action for ncRNAs processes IDD are still completely unrevealed. Therefore, it challenging consider be used therapeutic targets In this paper, we reviewed current research progress findings on IDD: i). participate process through regulating apoptosis nucleus pulposus (NP) cells, metabolism extracellular matrix (ECM) inflammatory response; ii). miRNAs/lncRNAs/circRNAs cross-talk development, similar network modulate each other; iii). attempted combat degenerative promising an efficient bio-therapeutic strategy future. Hence, review systematically summarizes principal pathomechanisms shed light potentials

Language: Английский

Citations

11
Functionalized Hydrogels for Cartilage Repair: The Value of Secretome-Instructive Signaling DOI Open Access
María Julia Barisón,

Rodrigo Nogoceke,

Raphaella Josino

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 6010 - 6010

Published: May 27, 2022

Cartilage repair has been a challenge in the medical field for many years. Although treatments that alleviate pain and injury are available, none can effectively regenerate cartilage. Currently, regenerative medicine tissue engineering among developed strategies to treat cartilage injury. The use of stem cells, associated or not with scaffolds, shown potential regeneration. However, it is currently known effect cells occurs mainly through secretion paracrine factors act on local cells. In this review, we will address secretome-a set bioactive (soluble extracellular vesicles) secreted by cells-of mesenchymal as treatment We also discuss methodologies priming secretome enhance chondroregenerative potential. addition, considering difficulty delivering therapies injured site, works hydrogels functionalized growth components. aim show secretome-functionalized be an exciting approach cell-free therapy.

Language: Английский

Citations

10
Novel insights of EZH2-mediated epigenetic modifications in degenerative musculoskeletal diseases DOI

Zetao Ma,

Lei Chen, Yushun Wang

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 90, P. 102034 - 102034

Published: Aug. 18, 2023

Language: Английский

Citations

6