Novel insights into the regulatory role of N6-methyladenosine methylation modified autophagy in sepsis DOI Creative Commons

Cheng-Fei Bi,

Jia Liu, Xiao Hu

et al.

Aging, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 18, 2023

Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. It characterized high morbidity and mortality one of the major diseases that seriously hang over global human health. Autophagy crucial regulator in complicated pathophysiological processes sepsis. The activation autophagy known be great significance for protecting sepsis induced dysfunction. Recent research has demonstrated N6-methyladenosine (m6A) methylation well-known post-transcriptional RNA modification controls epigenetic gene expression well number biological In addition, m6A affects stability, export, splicing translation transcripts involved autophagic process. Although it been suggested regulates metabolic more frequently seen progression pathogenesis, underlying molecular mechanisms m6A-modified have not thoroughly elucidated. present article fills this gap providing an review its potential role development novel therapeutics.

Language: Английский

Hypoxia Triggers Cardiomyocyte Apoptosis Via Regulating the M6a Methylation-Mediated LncMIAT/miR-708-5p/p53 Axis DOI
Chuqiao Shen, Xiaoqi Chen,

Yixuan Lin

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
m6A methylation in myocardial tissue of septic mice analyzed using MeRIP/m6A-sequencing and RNA-sequencing DOI
Xue Liang,

Xiaotong Hu,

Jiao Li

et al.

Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(5)

Published: Sept. 25, 2024

Language: Английский

Citations

0
N6-methyladenosine (m6A) writer METTL3 accelerates the apoptosis of vascular endothelial cells in high glucose DOI Creative Commons

Zhenjin Li,

Xuying Meng,

Yu Chen

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: Aug. 23, 2022

Abstract Recent studies have shown that N6-methyladenosine (m6A) methylation, one of the most prevalent epigenetic modifications, is involved in diabetes mellitus. However, whether m6A plays roles diabetic vascular endothelium injury still elusive. Present research aimed to investigate regulation and mechanism on injury. Upregulation METTL3 was observed high glucose (HG)-induced human umbilical vein endothelial cells (HUVECs), followed by upregulation methylation level. Functionally, silencing repressed apoptosis recovered proliferation HUVECs disposed HG. Moreover, HG exposure upregulated expression suppressor cytokine signalling 3 (SOCS3). Mechanistically, targeted modified site SOCS3 genomic, which positively regulated mRNA stability mRNA. In conclusion, attenuated HG-induced cell via promoting expression. Our expands understanding vasculopathy mellitus provides a potential strategy for protection

Language: Английский

Citations

2
Novel insights into the regulatory role of N6-methyladenosine methylation modified autophagy in sepsis DOI Creative Commons

Cheng-Fei Bi,

Jia Liu, Xiao Hu

et al.

Aging, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 18, 2023

Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. It characterized high morbidity and mortality one of the major diseases that seriously hang over global human health. Autophagy crucial regulator in complicated pathophysiological processes sepsis. The activation autophagy known be great significance for protecting sepsis induced dysfunction. Recent research has demonstrated N6-methyladenosine (m6A) methylation well-known post-transcriptional RNA modification controls epigenetic gene expression well number biological In addition, m6A affects stability, export, splicing translation transcripts involved autophagic process. Although it been suggested regulates metabolic more frequently seen progression pathogenesis, underlying molecular mechanisms m6A-modified have not thoroughly elucidated. present article fills this gap providing an review its potential role development novel therapeutics.

Language: Английский

Citations

0