Unveiling the Potential of Extracellular Vesicles as Biomarkers and Therapeutic Nanotools for Gastrointestinal Diseases

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 567 - 567

Published: April 21, 2024

Extracellular vesicles (EVs), acting as inherent nanocarriers adept at transporting a range of different biological molecules such proteins, lipids, and genetic material, exhibit diverse functions within the gastroenteric tract. In states normal health, they participate in upkeep systemic organ homeostasis. Conversely, pathological conditions, significantly contribute to pathogenesis gastrointestinal diseases (GIDs). Isolating EVs from patients' biofluids facilitates discovery new biomarkers that have potential offer rapid, cost-effective, non-invasive method for diagnosing prognosing specific GIDs. Furthermore, demonstrate considerable therapeutic naturally targeted physiological carriers intercellular delivery cargo or nanoscale tools engineered specifically regulate physio-pathological conditions disease progression. Their attributes including safety, high permeability, stability, biocompatibility, low immunogenicity, homing/tropism capabilities their promising clinical applications. This review will delve into various examples serving context GIDs, highlighting both functional structural conditions. The versatile advantageous properties position them candidates innovative strategies advancing personalized medicine approaches tailored tract, addressing

Language: Английский

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Hydrogel encapsulation of mesenchymal stem cells-derived extracellular vesicles as a novel therapeutic approach in cancer therapy

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(5), P. 189177 - 189177

Published: Aug. 30, 2024

Language: Английский

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Engineering exosomes for bone defect repair

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: Dec. 7, 2022

Currently, bone defect repair is still an intractable clinical problem. Numerous treatments have been performed, but their results are unsatisfactory. As a key element of cell-free therapy, exosome becoming promising tool regeneration in recent decades, because its promoting osteogenesis and osteogenic differentiation function vivo vitro . However, low yield, weak activity, inefficient targeting ability, unpredictable side effects natural exosomes limited the application. To overcome weakness, various approaches applied to produce engineering by regulating production at present. In this review, we will focus on for repair. By summarizing exosomal cargos affecting osteogenesis, strategies properties exosome-integrated biomaterials, work provide novel insights into exploring advanced exosome-based therapy

Language: Английский

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MXene-reinforced bioactive polymer hydrogels for biomedical applications

APL Materials, Journal Year: 2024, Volume and Issue: 12(8)

Published: Aug. 1, 2024

MXenes, a novel class of two-dimensional (2D) materials, have attracted considerable attention in various fields, especially drug delivery, wound healing, bone tissue engineering, biosensing, and cancer treatment. Thanks to their remarkable physicochemical properties, MXenes hold great promise for biomedical applications. Concurrently, hydrogels composed polymers been extensively utilized contexts. The unique properties facilitate integration into bioactive with enhanced functions thereby endowing the composites multifunctional capabilities. MXene-reinforced polymer (MRPHs) synergistically combine advantageous characteristics both hydrogels, making them highly adaptable other theranostic strategies medical In this comprehensive review, we demonstrate recent advances design synthesis MRPHs Specifically, introduce analyze methods tailoring by incorporating active components, including functional molecules, 2D metal ions, natural polymers, drugs/genes. We then discuss applications designed biosensors, therapy. hope that work provides valuable guidance inspiration readers develop advanced

Language: Английский

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Revolutionizing cancer treatment via bioengineered extracellular vesicles: Exploring nanovesicles to fully synthetic solutions

Applied Materials Today, Journal Year: 2024, Volume and Issue: 40, P. 102395 - 102395

Published: Aug. 28, 2024

The prevalence of cancer on a global scale has necessitated the development various therapeutic approaches. However, effectiveness and safety existing methods often face some limitations. Nanotechnology emerged as solution, enabling design nanosystems that can effectively deliver drugs. These address challenges such low drug stability solubility, well lack tumor targetability. While nanomaterials offer advantages, certain nanoparticles have their own limitations, which prompted researchers to explore innovative delivery systems. One promising avenue is use extracellular vesicles (EVs), are natural secreted by cells. EVs possess biocompatibility, stability, targeting capabilities, making them ideal candidates for carriers. still remain in this field. include limited production yield, complexity, inefficient cargo loading, controlled release To overcome these challenges, been employing engineering techniques modify structures EVs, enhancing intrinsic properties. Surface modification hybrid systems combine with other shown potential addressing This review focuses landscape crucial role therapeutics diagnosis. It begins exploring biological functions properties EVs. Additionally, introduces strategies isolating shedding light methodologies used harvest minute entities. Finally, highlights biomedical applications bioengineering treatment.

Language: Английский

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