Journal of Physical Education and Sport,
Journal Year:
2022,
Volume and Issue:
22(7)
Published: July 31, 2022
Physical
activity
combined
with
a
polyphenols
rich
diet
have
been
recently
emerged
as
non-pharmacological
approach
able
to
prevent
and/or
ameliorate
symptoms
that
are
related
the
disfunctions
of
energy-related
health
processes,
in
particular
during
aging.In
this
article
we
first
described
key
role
mitochondrial
functions
energy
production
systems
activated
different
types
physical
activity.Then,
reported
some
relevant
and
recent
aspects
concerning
aging-related
involved
several
human
diseases,
providing
an
overview
most
vivo
vitro
studies.These
studies
aimed
identification
molecular
mechanisms
causing
including
DNA
mutations,
radical
oxygen
species
(ROS)
generation
oxidative
stress,
led
sarcopenia.These
results
explored
major
approaches
used
for
prevention
treatments
diseases.In
particular,
highlighted
effects
exercise
plant
on
function
aerobic
mechanism
ATP
synthesis.In
fact,
secretion
myokines
from
contracting
skeletal
muscle
allows
modulation
various
metabolic
processes
can
improve
mitochondria
cell
bioenergetic
functions.Polyphenol
intake
has
shown
counteract
alterations
inflammation
therefore
describe
these
molecules,
also
pure
form,
food
integration,
summarized
their
functions.Finally,
reviewed
state
art
strategies
focusing
both
polyphenols-rich
based
humans
aim
diseases.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(1), P. 86 - 86
Published: Jan. 10, 2024
Tendinopathy
is
a
debilitating
condition
marked
by
degenerative
changes
in
the
tendons.
Its
complex
pathophysiology
involves
intrinsic,
extrinsic,
and
physiological
factors.
While
its
intrinsic
extrinsic
factors
have
been
extensively
studied,
role
of
factors,
such
as
hypoxia
oxidative
stress,
remains
largely
unexplored.
This
review
article
delves
into
contribution
hypoxia-associated
genes
oxidative-stress-related
to
tendon
degeneration,
offering
insights
potential
therapeutic
strategies.
The
unique
aspect
this
study
lies
pathway-based
evidence,
which
sheds
light
on
how
these
can
be
targeted
enhance
overall
health.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 12, 2024
As
the
primary
solid
phase,
amorphous
calcium
phosphate
(ACP)
is
a
pivotal
precursor
in
cellular
biomineralization.
The
intrinsic
interplay
between
ACP
and
Howard
factor
underscores
significance
of
understanding
their
association
for
advancing
biomimetic
development.
While
organic
compounds
play
established
roles
biomineralization,
this
study
presents
synthesis
with
naturally
occurring
(ascorbate,
glutamate,
itaconate)
ubiquitously
found
mitochondria
vital
bone
remodeling
healing.
developed
was
meticulously
characterized
using
XRD,
FTIR,
solid-state
13
C
31
P
NMR.
morphological
analysis
revealed
characteristic
spherical
morphology
particle
size
close
to
20
nm
all
synthesized
variants.
Notably,
type
compound
strongly
influences
true
density,
specific
surface
area,
size,
transformation.
vitro
performed
MC3T3-E1
cells,
indicating
highest
cell
viability
ACP_ASC
(ascorbate),
followed
by
ACP_ITA
(itaconate).
lowest
observed
10
%w/v
ACP_GLU
(glutamate);
however,
1
cytocompatible.
Further,
effect
small
molecules
on
transformation
low
crystalline
apatite
(Ap)
examined
Milli-Q
®
water,
PBS,
α-MEM.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Aging
is
an
inevitable
and
complex
biological
process
involving
multi-factorial
mechanisms.
Mitochondrial
dysfunction
a
critical
factor
in
the
aging
process,
characterized
by
decline
mitochondrial
quality
activity,
leading
to
aging-related
diseases.
Therefore,
mitochondria
have
become
attractive
target
anti-aging
therapies.
Several
senolytic
drugs
targeting
antioxidant
agents
been
used
research
past
few
years.
However,
these
strategies
may
cause
adverse
effects
with
long-term
medication.
In
this
extensive
review,
we
propose
"mitochondrial
transplantation,"
which
transfers
healthy
from
donor
cells
recipient
replace
damaged
or
dysfunctional
mitochondria,
as
new
alternative
strategy
for
treating
aging-associated
introduce
contemporary
landscape
of
transplantation,
then
discuss
intensely
successful
applications
transplantation
therapy
diseases
such
neurodegenerative
diseases,
cardiovascular
aging,
reproductive
highlighting
its
translational
potential.
Finally,
summarize
prospect
challenges
opportunities
faces
therapy.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(21), P. 3663 - 3663
Published: Oct. 28, 2024
Background/Objectives:
The
human
gut
microbiome
is
a
complex
ecosystem
of
microorganisms
that
can
influence
our
health
and
exercise
habits.
On
the
other
hand,
physical
also
impact
microbiome,
affecting
health.
Our
narrative
review
examines
bidirectional
relationship
between
activity
as
well
potential
for
targeted
probiotic
regimens
to
enhance
sports
performance.
Methods:
We
conducted
comprehensive
literature
select
articles
published
up
till
January
2024
on
topics
exercise,
sports,
probiotics,
microbiota
from
major
scientific
databases,
incorporating
over
100
studies.
Results:
found
varies
with
type
intensity
exercise.
Moderate
promotes
healthy
immune
system,
while
high-intensity
long
duration
cause
leaky
consequent
systemic
inflammation,
which
may
disrupt
microbial
balance.
Combining
aerobic
resistance
training
significantly
affects
bacterial
diversity,
linked
lower
prevalence
chronic
metabolic
disorders.
Furthermore,
enhances
increases
SCFA
production,
improves
nutrient
utilization,
modulates
neural
hormonal
pathways,
improving
barrier
integrity.
findings
showed
supplementation
associated
decreased
enhanced
performance,
fewer
gastrointestinal
disturbances,
suggesting
mutually
influential.
Conclusions:
exemplified
by
how
promote
beneficial
bacteria
potentially
ability
through
various
mechanisms.
These
underscore
importance
adding
tailored
consider
individual
profiles
into
programs.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(8), P. 1576 - 1576
Published: Aug. 7, 2023
Loss
of
skeletal
muscle
mass
and
function
has
detrimental
effects
on
quality
life,
morbidity,
mortality,
is
particularly
relevant
in
aging
societies.
The
enhancement
mitochondrial
shown
promise
promoting
differentiation
function.
Ginsenoside
Rc
(gRc),
a
major
component
ginseng,
various
pharmacological
activities;
however,
its
effect
loss
remains
poorly
explored.
In
this
study,
we
examined
the
gRc
hydrogen
peroxide
(H2O2)-induced
reduction
cell
viability
C2C12
myoblasts
myotubes
H2O2-induced
myotube
degradation.
addition,
investigated
production
intracellular
reactive
oxygen
species
(ROS)
superoxide,
ATP
generation,
peroxisome
proliferator-activated
receptor-gamma
co-activator
1α
(PGC-1α)
activity
under
H2O2
treatment.
Furthermore,
to
elucidate
mechanism
action
gRc,
conducted
transcriptome
analysis
treated
with
or
without
effectively
suppressed
cytotoxicity,
ROS,
superoxide
production,
restored
PGC-1α
promoter
activity,
increased
synthesis.
Moreover,
significantly
affected
expression
levels
genes
involved
maintaining
biogenesis,
while
downregulating
associated
degradation
oxidative
stress.
We
provide
compelling
evidence
supporting
potential
as
promising
treatment
for
weakness.
Further
investigations
pathological
conditions
will
contribute
clinical
development
therapeutic
intervention.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(3), P. 602 - 602
Published: March 1, 2023
Many
muscular
pathologies
are
associated
with
oxidative
stress
and
elevated
levels
of
the
tumor
necrosis
factor
(TNF)
that
cause
muscle
protein
catabolism
impair
myogenesis.
Myogenesis
defects
caused
by
TNF
mediated
in
part
reactive
oxygen
species
(ROS),
including
those
produced
mitochondria
(mitoROS),
but
mechanism
their
pathological
action
is
not
fully
understood.
We
hypothesized
mitoROS
act
triggering
enhancing
mitophagy,
an
important
tool
for
remodelling
mitochondrial
reticulum
during
used
three
recently
developed
probes-MitoTracker
Orange
CM-H2TMRos,
mito-QC,
MitoCLox-to
study
myogenesis
human
myoblasts.
Induction
resulted
a
significant
increase
generation
phospholipid
peroxidation
inner
membrane,
as
well
mitophagy
enhancement.
Treatment
myoblasts
24
h
before
induction
decrease
myoblast
fusion
index
myosin
heavy
chain
(MYH2)
synthesis.
increased
mitoROS,
membrane
at
early
stage
differentiation.
Trolox
SkQ1
antioxidants
partially
restored
TNF-impaired
The
general
autophagy
inducers
rapamycin
AICAR,
which
also
stimulate
completely
blocked
suppression
ULK1
inhibitor
SBI-0206965
impaired
TNF.
Thus,
mitoROS-dependent
mitophagy.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Abstract
Mitochondrial
transfer
emerges
as
a
promising
therapy
for
the
restoration
of
mitochondrial
function
in
damaged
cells,
mainly
due
to
its
limited
immunogenicity.
However,
isolated
mitochondria
rapidly
lose
because
they
produce
little
energy
outside
cells.
Therefore,
this
study
investigates
whether
near
infrared
(NIR)‐mediated
nicotinamide
adenine
dinucleotide
(NADH)
pre‐treatment
enhances
and
stability
mitochondria‐donor
cells
prior
transplantation.
Clinical
applications
NADH,
an
essential
electron
donor
oxidative
phosphorylation
process,
are
restricted
cellular
uptake
NADH.
To
address
this,
photo‐mediated
method
optimizes
direct
NADH
delivery
into
increases
absorption.
L6
treated
with
irradiated
NIR
enhanced
uptake,
significantly
improving
production
function.
Importantly,
improved
functional
characteristics
maintained
even
after
isolation
from
Primed
mitochondria,
i.e.,
those
by
NIR‐mediated
(P‐MT),
encapsulated
fusogenic
liposomes
delivered
muscle
dysfunction.
Compared
conventional
P‐MT
promote
greater
recovery
regeneration.
These
findings
suggest
that
is
effective
strategy
function,
has
potential
lead
novel
treatments
disorders
degeneration.
Communications Biology,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: April 9, 2025
Cancer
cachexia
is
a
cancer-associated
disease
characterized
by
gradual
body
weight
loss
due
to
pathologic
muscle
and
fat
loss,
but
effective
treatments
are
still
lacking.
Here,
we
investigate
the
possible
effect
of
vanillic
acid
(VA),
known
for
its
antioxidant,
anti-inflammatory,
anti-obesity
effects,
on
mitochondria-mediated
improvement
cancer
cachexia.
We
utilized
cachexia-like
models
using
CT26
colon
dexamethasone.
VA
improved
representative
parameters
including
increased
serum
intereukin-6
levels.
also
attenuated
in
tibialis
anterior
gastrocnemius
muscles,
inhibited
proteolytic
markers
RING-finger
protein-1
(MURF1)
atrophy
F-box
(MAFbx)
mitochondrial
function
through
alteration
sirtuins
3
(SIRT3)
mitofusin
1
(MFN1).
Importantly,
silencing
SIRT3
gene
abolished
VA,
indicating
that
important
mechanism
action
VA.
Overall,
suggest
as
novel
therapeutic
agent
can
fundamentally
treat
recover
patients.