Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 10, 2024
Cancer
immunotherapy,
such
as
immune
checkpoint
blockade
(ICB),
has
emerged
a
groundbreaking
approach
for
effective
cancer
treatment.
Despite
its
considerable
potential,
clinical
studies
have
indicated
that
the
current
response
rate
to
immunotherapy
is
suboptimal,
primarily
attributed
low
immunogenicity
in
certain
types
of
malignant
tumors.
Immunogenic
cell
death
(ICD)
represents
form
regulated
(RCD)
capable
enhancing
tumor
and
activating
tumor-specific
innate
adaptive
responses
immunocompetent
hosts.
Therefore,
gaining
deeper
understanding
ICD
evolution
crucial
developing
more
therapeutic
strategies.
This
review
focuses
exclusively
on
both
historical
recent
discoveries
related
modes
their
mechanistic
insights,
particularly
within
context
immunotherapy.
Our
findings
are
also
highlighted,
revealing
mode
induction
facilitated
by
atypical
interferon
(IFN)-stimulated
genes
(ISGs),
including
polo-like
kinase
2
(
PLK2
),
during
hyperactive
type
I
IFN
signaling.
The
concludes
discussing
potential
ICD,
with
special
attention
relevance
preclinical
settings
field
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
Abstract
Cuproptosis,
a
recently
defined
copper‐dependent
cell
death
pathway,
remains
largely
unexplored
in
tumor
therapies,
particularly
breast
cancer.
This
study
demonstrates
that
triple‐negative
cancer
(TNBC)
bears
relatively
elevated
copper
levels
and
exhibits
resistance
to
cuproptosis.
Mechanistically,
activates
the
AKT
signaling
which
inhibits
ferredoxin‐1
(FDX1),
key
regulator
of
AKT1‐mediated
FDX1
phosphorylation
not
only
abrogates
FDX1‐induced
cuproptosis
aerobic
respiration
but
also
promotes
glycolysis.
Consequently,
combination
AKT1
inhibitors
ionophores
synergistically
alleviate
TNBC
tumorigenesis
both
vitro
vivo.
In
summary,
findings
reveal
crucial
mechanism
underlying
suggest
potential
therapeutic
approach
for
TNBC.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: Nov. 7, 2023
The
sustenance
of
human
life
activities
depends
on
copper,
which
also
serves
as
a
crucial
factor
for
vital
enzymes.
Under
typical
circumstances,
active
homeostatic
mechanisms
keep
the
intracellular
copper
ion
concentration
low.
Excess
ions
cause
excessive
cellular
respiration,
causes
cytotoxicity
and
cell
death
levels
steadily
rise
above
threshold.
It
is
novel
that
mitochondrial
ions,
regulation.
Cuproptosis
now
understood
to
play
role
in
several
pathogenic
processes,
including
inflammation,
oxidative
stress,
apoptosis.
Copper
type
regulatory
death(RCD).Numerous
diseases
are
correlated
with
development
homeostasis
imbalances.
One
most
popular
areas
study
field
cancer
cuproptosis.
has
been
discovered
angiogenesis,
proliferation,
growth,
metastasis
all
accumulation
ions.
concentrations
can
serve
marker
development.
In
order
reference
clinical
research
product,
diagnosis,
treatment
cancer,
this
paper
covers
function
imbalance
malignant
cancers
related
molecular
pathways.
Antioxidants and Redox Signaling,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Feb. 2, 2023
Significance:
As
a
redox-sensitive
protein,
high-mobility
group
box
1
(HMGB1)
is
implicated
in
regulating
stress
responses
to
oxidative
damage
and
cell
death,
which
are
closely
related
the
pathology
of
inflammatory
diseases,
including
cancer.
Recent
advances:
HMGB1
non-histone
nuclear
protein
that
acts
as
DNA
chaperone
control
chromosomal
structure
function.
can
also
be
released
into
extracellular
space
function
damage-associated
molecular
pattern
during
apoptosis,
necrosis,
necroptosis,
pyroptosis,
ferroptosis,
alkaliptosis,
cuproptosis.
Once
released,
binds
membrane
receptors
shape
immune
metabolic
responses.
In
addition
subcellular
localization,
activity
depends
on
its
redox
state
posttranslational
modifications.
Abnormal
plays
dual
role
tumorigenesis
anticancer
therapy
(e.g.,
chemotherapy,
radiation
therapy,
immunotherapy)
depending
tumor
types
stages.
Critical
issues:
A
comprehensive
understanding
cellular
homeostasis
important
for
deciphering
normal
functions
pathological
manifestations.
this
review,
we
discuss
compartmental-defined
roles
death
Understanding
these
advances
may
help
us
develop
potential
HMGB1-targeting
drugs
or
approaches
treat
stress-related
diseases
conditions.
Future
directions:
Further
studies
required
dissect
mechanism
by
maintains
under
different
multidisciplinary
effort
evaluate
applications
precisely
targeting
pathway
human
health
disease.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: April 23, 2024
The
expanding
geriatric
population,
whose
predisposition
toward
disabling
morbidities
and
age-related
diseases
(ARD)
is
well-documented,
has
become
a
paramount
social
issue,
exerting
an
onerous
burden
on
both
the
healthcare
industry
wider
society.
ARD
manifest
as
progressive
deterioration
of
bodily
tissues
organs,
eventually
resulting
in
failure
these
vital
components.
At
present,
no
efficacious
measures
exist
to
hinder
onset
ARD.
Copper,
essential
trace
element,
involved
wide
range
physiological
processes
across
different
cell
types.
In
recent
research,
novel
variant
copper-dependent
death,
termed
cuproptosis,
been
identified.
This
mode
cellular
demise
stands
apart
from
previously
recognized
types
death.
Cuproptosis
occurs
when
copper
binds
with
acyl-CoA
synthetase
tricarboxylic
acid
(TCA)
cycle,
protein
aggregation
toxicity
stress,
ultimately
leading
this
paper,
we
provide
concise
overview
current
understanding
concerning
metabolism
copper,
copper-related
diseases,
hallmarks
toxicity,
mechanisms
that
regulate
toxicity.
Additionally,
discuss
implications
cuproptosis
mutations
development
ARD,
well
potential
for
targeting
treatment
